Biology and medicine have evolved with the advance of measurement technologies which focused on acquisition of life data at finer resolutions and larger scales. Molecular analysis including genomics, transcriptomics, and proteomics, as well as imaging methods including non-destructive optical imaging and recently revolutionized cryo-EM imaging at astonishing resolutions are good examples. On the other hand, multi-disciplinary knowledge and technological platforms allowed us to shed light on complex life systems from a new angle. Adopting fluidic technologies as a platform such as flow cytometry, microfluidics, and capillary devices, utilizing functional biomaterials, understanding cells and molecules from the perspective of bio- and soft matter physics, and recent integration of remarkable data and information science are good examples. Here at LSBM, we learn from the history and create future by not only developing hardware methods exhibiting the worlds’ best specifications but also developing a key framework for discovering valuable information in the biological measurement. Across different machines, modalities, scales, and layers, we perform research and development through close collaborations between technologies and biomedical scientists.
WHAT TO READ NEXT
YOU MAY ALSO BE INTERESTED IN
- High-speed molecular spectral imaging of tissue with stimulated Raman scattering. Y. Ozeki, W. Umemura, Y. Otsuka, S. Satoh, H. Hashimoto, K. Sumimura, N. Nishizawa, K. Fukui and K. ItohNature Photon. vol. 6, pp. 845-851, 2012. https://doi.org/10.1038/nphoton.2012.263
- Super-multiplex imaging of cellular dynamics and heterogeneity by integrated stimulated Raman and fluorescence microscopy Shou J, Oda R, Hu F, Karasawa K, Nuriya M, Yasui M, Shiramizu B, Min W, Ozeki Y.iScience. 2021 Jul 9;24(8):102832. doi: 10.1016/j.isci.2021.102832. eCollection 2021 Aug 20.
- Imaging the uptake of deuterated methionine in Drosophila with stimulated Raman scattering. Spratt SJ, Mizuguchi T, Akaboshi H, Kosakamoto H, Okada R, Obata F, Ozeki Y.Front Chem. 2023 Mar 29;11:1141920. doi: 10.3389/fchem.2023.1141920. eCollection 2023.
- Dissecting the stability determinants of a challenging de novo protein fold using massively parallel design and experimentation. Kim TE, Tsuboyama K, Houliston S, Martell CM, Phoumyvong CM, Lemak A, Haddox HK, Arrowsmith CH, Rocklin GJ.Proc Natl Acad Sci U S A. 2022 Oct 11;119(41):e2122676119. doi: 10.1073/pnas.2122676119. Epub 2022 Oct 3.