PUBLICATION

• What consequence is anticipated by the emergence of novel SPPARMa agent developed so as to achieve an improved safety/efficacy balance? Motonobu Anai, Toshiya Tanaka, Tatsuhiko Kodama.Jpn Pharmacol Ther. 46: 471-480 (2018). Discovery of peroxisome proliferator-activated receptor α (PPARα) activators with a ligand-screening system using a human PPARα-expressing cell line. Tachibana K, Yuzuriha T, Tabata R, Fukuda S, Maegawa T, Takahashi R, Tanimoto K, Tsujino H, Nunomura K, Lin B, Matsuura Y, Tanaka T, Hamakubo T, Sakai J, Kodama T, Kobayashi T, Ishimoto K, Miyachi H, Doi T.J. Biol. Chem. 2018 06 29;293(26):10333-10343. doi: 10.1074/jbc.RA118.002077 Overexpression of p54nrb/NONO induces differential EPHA6 splicing and contributes to castration-resistant prostate cancer growth. Yamamoto R, Osawa T, Sasaki Y, Yamamoto S, Anai M, Izumi K, Matsumura Y, Sakai J, Aburatani H, Mizokami A, Kodama T, Tanaka T.Oncotarget. 2018 Jan 8;9(12):10510-10524. doi: 10.18632/oncotarget.24063. The Influence of Pemafibrate (Parmodia Tablet) on Liver and Renal Function Toshiya Tanaka, Motonobu Anai, and Tatsuhiko KodamaJ Pharmacol Ther. 2017 Nov 20; 45(11):1775-1785. Aberrant DNA methylation of pregnane X receptor underlies metabolic gene alterations in the diabetic kidney. Watanabe A, Marumo T, Kawarazaki W, Nishimoto M, Ayuzawa N, Ueda K, Hirohama D, Tanaka T, Yagi S, Ota S, Nagae G, Aburatani H, Kumagai H, Fujita T.Am. J. Physiol. Renal Physiol. 2018 04 01;314(4):F551-F560. doi: 10.1152/ajprenal.00390.2017 Degradation of human Lipin-1 by BTRC E3 ubiquitin ligase. Ishimoto K, Hayase A, Kumagai F, Kawai M, Okuno H, Hino N, Okada Y, Kawamura T, Tanaka T, Hamakubo T, Sakai J, Kodama T, Tachibana K, Doi T.Biochem. Biophys. Res. Commun. 2017 06 17;488(1):159-164. doi: 10.1016/j.bbrc.2017.04.159 Ubiquitination of Lysine 867 of the Human SETDB1 Protein Upregulates Its Histone H3 Lysine 9 (H3K9) Methyltransferase Activity. Ishimoto K, Kawamata N, Uchihara Y, Okubo M, Fujimoto R, Gotoh E, Kakinouchi K, Mizohata E, Hino N, Okada Y, Mochizuki Y, Tanaka T, Hamakubo T, Sakai J, Kodama T, Inoue T, Tachibana K, Doi T.PLoS ONE. 2016;11(10):e0165766. doi: 10.1371/journal.pone.0165766 H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-Specific DNA Methylation Pauses Adipocyte Differentiation. Matsumura Y, Nakaki R, Inagaki T, Yoshida A, Kano Y, Kimura H, Tanaka T, Tsutsumi S, Nakao M, Doi T, Fukami K, Osborne TF, Kodama T, Aburatani H, Sakai J.Mol. Cell. 2015 Nov 19;60(4):584-96. doi: 10.1016/j.molcel.2015.10.025 Analysis of the subcellular localization of the human histone methyltransferase SETDB1. Tachibana K, Gotoh E, Kawamata N, Ishimoto K, Uchihara Y, Iwanari H, Sugiyama A, Kawamura T, Mochizuki Y, Tanaka T, Sakai J, Hamakubo T, Kodama T, Doi T.Biochem. Biophys. Res. Commun. 2015 Oct 02;465(4):725-31. doi: 10.1016/j.bbrc.2015.08.065 Transcriptome Analysis of K-877 (a Novel Selective PPARα Modulator (SPPARMα))-Regulated Genes in Primary Human Hepatocytes and the Mouse Liver. Raza-Iqbal S, Tanaka T, Anai M, Inagaki T, Matsumura Y, Ikeda K, Taguchi A, Gonzalez FJ, Sakai J, Kodama T.J. Atheroscler. Thromb. 2015 Aug 26;22(8):754-72. doi: 10.5551/jat.28720 JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis. Abe Y, Rozqie R, Matsumura Y, Kawamura T, Nakaki R, Tsurutani Y, Tanimura-Inagaki K, Shiono A, Magoori K, Nakamura K, Ogi S, Kajimura S, Kimura H, Tanaka T, Fukami K, Osborne TF, Kodama T, Aburatani H, Inagaki T, Sakai J.Nat Commun. 2015 May 07;6:7052. doi: 10.1038/ncomms8052 The FBXL10/KDM2B scaffolding protein associates with novel polycomb repressive complex-1 to regulate adipogenesis. Inagaki T, Iwasaki S, Matsumura Y, Kawamura T, Tanaka T, Abe Y, Yamasaki A, Tsurutani Y, Yoshida A, Chikaoka Y, Nakamura K, Magoori K, Nakaki R, Osborne TF, Fukami K, Aburatani H, Kodama T, Sakai J.J. Biol. Chem. 2015 Feb 13;290(7):4163-77. doi: 10.1074/jbc.M114.626929 PPARβ/δ activation of CD300a controls intestinal immunity. Tanaka T, Tahara-Hanaoka S, Nabekura T, Ikeda K, Jiang S, Tsutsumi S, Inagaki T, Magoori K, Higurashi T, Takahashi H, Tachibana K, Tsurutani Y, Raza S, Anai M, Minami T, Wada Y, Yokote K, Doi T, Hamakubo T, Auwerx J, Gonzalez FJ, Nakajima A, Aburatani H, Naito M, Shibuya A, Kodama T, Sakai J.Sci Rep. 2014 Jun 24;4:5412. doi: 10.1038/srep05412 Direct evidence for pitavastatin induced chromatin structure change in the KLF4 gene in endothelial cells. Maejima T, Inoue T, Kanki Y, Kohro T, Li G, Ohta Y, Kimura H, Kobayashi M, Taguchi A, Tsutsumi S, Iwanari H, Yamamoto S, Aruga H, Dong S, Stevens JF, Poh HM, Yamamoto K, Kawamura T, Mimura I, Suehiro J, Sugiyama A, Kaneki K, Shibata H, Yoshinaka Y, Doi T, Asanuma A, Tanabe S, Tanaka T, Minami T, Hamakubo T, Sakai J, Nozaki N, Aburatani H, Nangaku M, Ruan X, Tanabe H, Ruan Y, Ihara S, Endo A, Kodama T, Wada Y.PLoS ONE. 2014;9(5):e96005. doi: 10.1371/journal.pone.0096005 Cross-enhancement of ANGPTL4 transcription by HIF1 alpha and PPAR beta/delta is the result of the conformational proximity of two response elements. Inoue T, Kohro T, Tanaka T, Kanki Y, Li G, Poh HM, Mimura I, Kobayashi M, Taguchi A, Maejima T, Suehiro J, Sugiyama A, Kaneki K, Aruga H, Dong S, Stevens JF, Yamamoto S, Tsutsumi S, Fujita T, Ruan X, Aburatani H, Nangaku M, Ruan Y, Kodama T, Wada Y.Genome Biol. 2014 Apr 10;15(4):R63. doi: 10.1186/gb-2014-15-4-r63 Human mannose-binding lectin 2 is directly regulated by peroxisome proliferator-activated receptors via a peroxisome proliferator responsive element. Tachibana K, Takeuchi K, Inada H, Sugimoto K, Ishimoto K, Yamashita M, Maegawa T, Yamasaki D, Osada S, Tanaka T, Rakugi H, Hamakubo T, Sakai J, Kodama T, Doi T.J. Biochem. 2013 Sep;154(3):265-73. doi: 10.1093/jb/mvt050 Two immunogenic passenger dendritic cell subsets in the rat liver have distinct trafficking patterns and radiosensitivities. Yu B, Ueta H, Kitazawa Y, Tanaka T, Adachi K, Kimura H, Morita M, Sawanobori Y, Qian HX, Kodama T, Matsuno K.Hepatology. 2012 Oct;56(4):1532-45. doi: 10.1002/hep.25795 Dynamic change of chromatin conformation in response to hypoxia enhances the expression of GLUT3 (SLC2A3) by cooperative interaction of hypoxia-inducible factor 1 and KDM3A. Mimura I, Nangaku M, Kanki Y, Tsutsumi S, Inoue T, Kohro T, Yamamoto S, Fujita T, Shimamura T, Suehiro J, Taguchi A, Kobayashi M, Tanimura K, Inagaki T, Tanaka T, Hamakubo T, Sakai J, Aburatani H, Kodama T, Wada Y.Mol. Cell. Biol. 2012 Aug;32(15):3018-32. doi: 10.1128/MCB.06643-11 Role of histone methylation and demethylation in adipogenesis and obesity. Okamura M, Inagaki T, Tanaka T, Sakai J.Organogenesis. 6(1):24-32. doi: 10.4161/org.6.1.11121 Novel repressor regulates insulin sensitivity through interaction with Foxo1. Nakae J, Cao Y, Hakuno F, Takemori H, Kawano Y, Sekioka R, Abe T, Kiyonari H, Tanaka T, Sakai J, Takahashi S, Itoh H.EMBO J. 2012 May 16;31(10):2275-95. doi: 10.1038/emboj.2012.97 Clinical significance of steroid and xenobiotic receptor and its targeted gene CYP3A4 in human prostate cancer. Fujimura T, Takahashi S, Urano T, Tanaka T, Zhang W, Azuma K, Takayama K, Obinata D, Murata T, Horie-Inoue K, Kodama T, Ouchi Y, Homma Y, Inoue S.Cancer Sci. 2012 Feb;103(2):176-80. doi: 10.1111/j.1349-7006.2011.02143.x Fenofibrate suppresses growth of the human hepatocellular carcinoma cell via PPARα-independent mechanisms. Yamasaki D, Kawabe N, Nakamura H, Tachibana K, Ishimoto K, Tanaka T, Aburatani H, Sakai J, Hamakubo T, Kodama T, Doi T.Eur. J. Cell Biol. 2011 Aug;90(8):657-64. doi: 10.1016/j.ejcb.2011.02.005 Long pentraxin 3 (PTX3) expression and release by neutrophils in vitro and in ulcerative colitis. Savchenko AS, Inoue A, Ohashi R, Jiang S, Hasegawa G, Tanaka T, Hamakubo T, Kodama T, Aoyagi Y, Ushiki T, Naito M.Pathol. Int. 2011 May;61(5):290-7. doi: 10.1111/j.1440-1827.2011.02651.x Proteomic analysis of native hepatocyte nuclear factor-4α (HNF4α) isoforms, phosphorylation status, and interactive cofactors. Daigo K, Kawamura T, Ohta Y, Ohashi R, Katayose S, Tanaka T, Aburatani H, Naito M, Kodama T, Ihara S, Hamakubo T.J. Biol. Chem. 2011 Jan 07;286(1):674-86. doi: 10.1074/jbc.M110.154732 Sterol-regulatory-element-binding protein 2 and nuclear factor Y control human farnesyl diphosphate synthase expression and affect cell proliferation in hepatoblastoma cells. Ishimoto K, Tachibana K, Hanano I, Yamasaki D, Nakamura H, Kawai M, Urano Y, Tanaka T, Hamakubo T, Sakai J, Kodama T, Doi T.Biochem. J. 2010 Jul 15;429(2):347-57. doi: 10.1042/BJ20091511 Therapeutic role of rifaximin in inflammatory bowel disease: clinical implication of human pregnane X receptor activation. Cheng J, Shah YM, Ma X, Pang X, Tanaka T, Kodama T, Krausz KW, Gonzalez FJ.J. Pharmacol. Exp. Ther. 2010 Oct;335(1):32-41. doi: 10.1124/jpet.110.170225 [Recent trends in PPARgamma agonist development of thiazolidinediones and non-thiazolidinediones]. Tanaka T.Nippon Rinsho. 2010 Feb;68(2):249-55. Regulation of the human SLC25A20 expression by peroxisome proliferator-activated receptor alpha in human hepatoblastoma cells. Tachibana K, Takeuchi K, Inada H, Yamasaki D, Ishimoto K, Tanaka T, Hamakubo T, Sakai J, Kodama T, Doi T.Biochem. Biophys. Res. Commun. 2009 Nov 20;389(3):501-5. doi: 10.1016/j.bbrc.2009.09.018 Immunohistochemical staining for P1 and P2 promoter-driven hepatocyte nuclear factor-4alpha may complement mucin phenotype of differentiated-type early gastric carcinoma. Takano K, Hasegawa G, Jiang S, Kurosaki I, Hatakeyama K, Iwanari H, Tanaka T, Hamakubo T, Kodama T, Naito M.Pathol. Int. 2009 Jul;59(7):462-70. doi: 10.1111/j.1440-1827.2009.02394.x Obesity and metabolic syndrome in histone demethylase JHDM2a-deficient mice. Inagaki T, Tachibana M, Magoori K, Kudo H, Tanaka T, Okamura M, Naito M, Kodama T, Shinkai Y, Sakai J.Genes Cells. 2009 Aug;14(8):991-1001. doi: 10.1111/j.1365-2443.2009.01326.x Sterol-mediated regulation of human lipin 1 gene expression in hepatoblastoma cells. Ishimoto K, Nakamura H, Tachibana K, Yamasaki D, Ota A, Hirano K, Tanaka T, Hamakubo T, Sakai J, Kodama T, Doi T.J. Biol. Chem. 2009 Aug 14;284(33):22195-205. doi: 10.1074/jbc.M109.028753 Expression of liver X receptor alpha and lipid metabolism in granulocyte-macrophage colony-stimulating factor-induced human monocyte-derived macrophage. Kazawa T, Kawasaki T, Sakamoto A, Imamura M, Ohashi R, Jiang S, Tanaka T, Iwanari H, Hamakubo T, Sakai J, Kodama T, Naito M.Pathol. Int. 2009 Mar;59(3):152-60. doi: 10.1111/j.1440-1827.2009.02343.x The peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha heterodimer targets the histone modification enzyme PR-Set7/Setd8 gene and regulates adipogenesis through a positive feedback loop. Wakabayashi K, Okamura M, Tsutsumi S, Nishikawa NS, Tanaka T, Sakakibara I, Kitakami J, Ihara S, Hashimoto Y, Hamakubo T, Kodama T, Aburatani H, Sakai J.Mol. Cell. Biol. 2009 Jul;29(13):3544-55. doi: 10.1128/MCB.01856-08 COUP-TFII acts downstream of Wnt/beta-catenin signal to silence PPARgamma gene expression and repress adipogenesis. Okamura M, Kudo H, Wakabayashi K, Tanaka T, Nonaka A, Uchida A, Tsutsumi S, Sakakibara I, Naito M, Osborne TF, Hamakubo T, Ito S, Aburatani H, Yanagisawa M, Kodama T, Sakai J.Proc. Natl. Acad. Sci. U.S.A. 2009 Apr 07;106(14):5819-24. doi: 10.1073/pnas.0901676106 Fasting-induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 2. Sakakibara I, Fujino T, Ishii M, Tanaka T, Shimosawa T, Miura S, Zhang W, Tokutake Y, Yamamoto J, Awano M, Iwasaki S, Motoike T, Okamura M, Inagaki T, Kita K, Ezaki O, Naito M, Kuwaki T, Chohnan S, Yamamoto TT, Hammer RE, Kodama T, Yanagisawa M, Sakai J.Cell Metab. 2009 Feb;9(2):191-202. doi: 10.1016/j.cmet.2008.12.008 Protein expression of nuclear receptors in human and murine tissues. Takegoshi S, Jiang S, Ohashi R, Savchenko AS, Iwanari H, Tanaka T, Hasegawa G, Hamakubo T, Kodama T, Naito M.Pathol. Int. 2009 Feb;59(2):61-72. doi: 10.1111/j.1440-1827.2008.02330.x Regulation of the human PDZK1 expression by peroxisome proliferator-activated receptor alpha. Tachibana K, Anzai N, Ueda C, Katayama T, Yamasaki D, Kirino T, Takahashi R, Ishimoto K, Komori H, Tanaka T, Hamakubo T, Ueda Y, Arai H, Sakai J, Kodama T, Doi T.FEBS Lett. 2008 Nov 26;582(28):3884-8. doi: 10.1016/j.febslet.2008.10.027 PGC-1alpha Gly482Ser polymorphism is associated with the plasma adiponectin level in type 2 diabetic men. Okauchi Y, Iwahashi H, Okita K, Yuan M, Matsuda M, Tanaka T, Miyagawa J, Funahashi T, Horikawa Y, Shimomura I, Yamagata K.Endocr. J. 2008 Dec;55(6):991-7. doi: 10.1507/endocrj.k08e-070 Antisense activity of 2',4'-BNA targeted to PPAR gamma in THP-1 and HCT116 cells. Tachibana K, Katayama T, Ueda C, Sumitomo M, Tagami M, Ishimoto K, Yamasaki D, Tanaka T, Hamakubo T, Sakai J, Kodama T, Obika S, Imanishi T, Doi T.Nucleic Acids Symp Ser (Oxf). 2007;(51):441-2. doi: 10.1093/nass/nrm221 Hepatocyte nuclear factor 4alpha contributes to thyroid hormone homeostasis by cooperatively regulating the type 1 iodothyronine deiodinase gene with GATA4 and Kruppel-like transcription factor 9. Ohguchi H, Tanaka T, Uchida A, Magoori K, Kudo H, Kim I, Daigo K, Sakakibara I, Okamura M, Harigae H, Sasaki T, Osborne TF, Gonzalez FJ, Hamakubo T, Kodama T, Sakai J.Mol. Cell. Biol. 2008 Jun;28(12):3917-31. doi: 10.1128/MCB.02154-07 Lipopolysaccharide induced expression of pentraxin 3 in human neutrophils and monocyte-derived macrophages. Imamura M, Kawasaki T, Savchenko AS, Ohashi R, Jiang S, Miyamoto K, Ito Y, Iwanari H, Sagara M, Tanaka T, Hamakubo T, Kodama T, Uchiyama M, Naito M.Cell. Immunol. 2007 Aug;248(2):86-94. doi: 10.1016/j.cellimm.2007.09.003 Expression of HNF-4alpha (MODY1), HNF-1beta (MODY5), and HNF-1alpha (MODY3) proteins in the developing mouse pancreas. Nammo T, Yamagata K, Tanaka T, Kodama T, Sladek FM, Fukui K, Katsube F, Sato Y, Miyagawa J, Shimomura I.Gene Expr. Patterns. 2008 Jan;8(2):96-106. doi: 10.1016/j.modgep.2007.09.006 Analysis of PPAR alpha function in human kidney cell line using siRNA. Tachibana K, Anzai N, Ueda C, Katayama T, Kirino T, Takahashi R, Yamasaki D, Ishimoto K, Tanaka T, Hamakubo T, Ueda Y, Arai H, Sakai J, Kodama T, Doi T.Nucleic Acids Symp Ser (Oxf). 2006;(50):257-8. doi: 10.1093/nass/nrl128 The expression pattern of nuclear receptors during cerebellar development. Qin J, Suh JM, Kim BJ, Yu CT, Tanaka T, Kodama T, Tsai MJ, Tsai SY.Dev. Dyn. 2007 Mar;236(3):810-20. doi: 10.1002/dvdy.21060 [Bile acids and control of lipid metabolism]. Tanaka T, Sakai J, Kodama T.Nippon Rinsho. 2007 Jul 28;65 Suppl 7:557-63. Downregulated P1 promoter-driven hepatocyte nuclear factor-4alpha expression in human colorectal carcinoma is a new prognostic factor against liver metastasis. Oshima T, Kawasaki T, Ohashi R, Hasegawa G, Jiang S, Umezu H, Aoyagi Y, Iwanari H, Tanaka T, Hamakubo T, Kodama T, Naito M.Pathol. Int. 2007 Feb;57(2):82-90. doi: 10.1111/j.1440-1827.2006.02061.x SOX6 suppresses cyclin D1 promoter activity by interacting with beta-catenin and histone deacetylase 1, and its down-regulation induces pancreatic beta-cell proliferation. Iguchi H, Urashima Y, Inagaki Y, Ikeda Y, Okamura M, Tanaka T, Uchida A, Yamamoto TT, Kodama T, Sakai J.J. Biol. Chem. 2007 Jun 29;282(26):19052-61. doi: 10.1074/jbc.M700460200 New therapeutic target for metabolic syndrome: PPARdelta. Takahashi S, Tanaka T, Sakai J.Endocr. J. 2007 Jun;54(3):347-57. doi: 10.1507/endocrj.kr-99 Cooperative interaction between hepatocyte nuclear factor 4 alpha and GATA transcription factors regulates ATP-binding cassette sterol transporters ABCG5 and ABCG8. Sumi K, Tanaka T, Uchida A, Magoori K, Urashima Y, Ohashi R, Ohguchi H, Okamura M, Kudo H, Daigo K, Maejima T, Kojima N, Sakakibara I, Jiang S, Hasegawa G, Kim I, Osborne TF, Naito M, Gonzalez FJ, Hamakubo T, Kodama T, Sakai J.Mol. Cell. Biol. 2007 Jun;27(12):4248-60. doi: 10.1128/MCB.01894-06 Expression of liver X receptor alpha in rat fetal tissues at different developmental stages. Sakamoto A, Kawasaki T, Kazawa T, Ohashi R, Jiang S, Maejima T, Tanaka T, Iwanari H, Hamakubo T, Sakai J, Kodama T, Naito M.J. Histochem. Cytochem. 2007 Jun;55(6):641-9. doi: 10.1369/jhc.6A7120.2007 [PPAR delta and metabolic syndrome]. Tanaka T.Nippon Yakurigaku Zasshi. 2006 Oct;128(4):225-30. doi: 10.1254/fpj.128.225 The expression profiles of nuclear receptors in the developing and adult kidney. Suh JM, Yu CT, Tang K, Tanaka T, Kodama T, Tsai MJ, Tsai SY.Mol. Endocrinol. 2006 Dec;20(12):3412-20. doi: 10.1210/me.2006-0312 Identification of human low-density lipoprotein receptor as a novel target gene regulated by liver X receptor alpha. Ishimoto K, Tachibana K, Sumitomo M, Omote S, Hanano I, Yamasaki D, Watanabe Y, Tanaka T, Hamakubo T, Sakai J, Kodama T, Doi T.FEBS Lett. 2006 Sep 04;580(20):4929-33. doi: 10.1016/j.febslet.2006.08.010 Dysregulated expression of P1 and P2 promoter-driven hepatocyte nuclear factor-4alpha in the pathogenesis of human cancer. Tanaka T, Jiang S, Hotta H, Takano K, Iwanari H, Sumi K, Daigo K, Ohashi R, Sugai M, Ikegame C, Umezu H, Hirayama Y, Midorikawa Y, Hippo Y, Watanabe A, Uchiyama Y, Hasegawa G, Reid P, Aburatani H, Hamakubo T, Sakai J, Naito M, Kodama T.J. Pathol. 2006 Apr;208(5):662-72. doi: 10.1002/path.1928 Peroxisome proliferator-activated receptor delta (PPARdelta), a novel target site for drug discovery in metabolic syndrome. Takahashi S, Tanaka T, Kodama T, Sakai J.Pharmacol. Res. 2006 Jun;53(6):501-7. doi: 10.1016/j.phrs.2006.03.019 Mouse lacking COUP-TFII as an animal model of Bochdalek-type congenital diaphragmatic hernia. You LR, Takamoto N, Yu CT, Tanaka T, Kodama T, Demayo FJ, Tsai SY, Tsai MJ.Proc. Natl. Acad. Sci. U.S.A. 2005 Nov 08;102(45):16351-6. doi: 10.1073/pnas.0507832102 Gene expression profiling of potential peroxisome proliferator-activated receptor (PPAR) target genes in human hepatoblastoma cell lines inducibly expressing different PPAR isoforms. Tachibana K, Kobayashi Y, Tanaka T, Tagami M, Sugiyama A, Katayama T, Ueda C, Yamasaki D, Ishimoto K, Sumitomo M, Uchiyama Y, Kohro T, Sakai J, Hamakubo T, Kodama T, Doi T.Nucl. Recept. 2005 Oct 03;3:3. doi: 10.1186/1478-1336-3-3 SOX6 attenuates glucose-stimulated insulin secretion by repressing PDX1 transcriptional activity and is down-regulated in hyperinsulinemic obese mice. Iguchi H, Ikeda Y, Okamura M, Tanaka T, Urashima Y, Ohguchi H, Takayasu S, Kojima N, Iwasaki S, Ohashi R, Jiang S, Hasegawa G, Ioka RX, Magoori K, Sumi K, Maejima T, Uchida A, Naito M, Osborne TF, Yanagisawa M, Yamamoto TT, Kodama T, Sakai J.J. Biol. Chem. 2005 Nov 11;280(45):37669-80. doi: 10.1074/jbc.M505392200 Identification of N-arachidonylglycine, U18666A, and 4-androstene-3,17-dione as novel insulin Secretagogues. Ikeda Y, Iguchi H, Nakata M, Ioka RX, Tanaka T, Iwasaki S, Magoori K, Takayasu S, Yamamoto TT, Kodama T, Yada T, Sakurai T, Yanagisawa M, Sakai J.Biochem. Biophys. Res. Commun. 2005 Aug 05;333(3):778-86. doi: 10.1016/j.bbrc.2005.06.005 Functional characterization of the HNF4alpha isoform (HNF4alpha8) expressed in pancreatic beta-cells. Ihara A, Yamagata K, Nammo T, Miura A, Yuan M, Tanaka T, Sladek FM, Matsuzawa Y, Miyagawa J, Shimomura I.Biochem. Biophys. Res. Commun. 2005 Apr 15;329(3):984-90. doi: 10.1016/j.bbrc.2005.02.072 A comparison of differences in the gene expression profiles of phorbol 12-myristate 13-acetate differentiated THP-1 cells and human monocyte-derived macrophage. Kohro T, Tanaka T, Murakami T, Wada Y, Aburatani H, Hamakubo T, Kodama T.J. Atheroscler. Thromb. 2004;11(2):88-97. doi: 10.5551/jat.11.88 Expression of the LXRalpha protein in human atherosclerotic lesions. Watanabe Y, Jiang S, Takabe W, Ohashi R, Tanaka T, Uchiyama Y, Katsumi K, Iwanari H, Noguchi N, Naito M, Hamakubo T, Kodama T.Arterioscler. Thromb. Vasc. Biol. 2005 Mar;25(3):622-7. doi: 10.1161/01.ATV.0000154489.53077.4e Synergy between LRH-1 and beta-catenin induces G1 cyclin-mediated cell proliferation. Botrugno OA, Fayard E, Annicotte JS, Haby C, Brennan T, Wendling O, Tanaka T, Kodama T, Thomas W, Auwerx J, Schoonjans K.Mol. Cell. 2004 Aug 27;15(4):499-509. doi: 10.1016/j.molcel.2004.07.009 Sall1, a causative gene for Townes-Brocks syndrome, enhances the canonical Wnt signaling by localizing to heterochromatin. Sato A, Kishida S, Tanaka T, Kikuchi A, Kodama T, Asashima M, Nishinakamura R.Biochem. Biophys. Res. Commun. 2004 Jun 18;319(1):103-13. doi: 10.1016/j.bbrc.2004.04.156 A Kruppel-like factor KLF15 contributes fasting-induced transcriptional activation of mitochondrial acetyl-CoA synthetase gene AceCS2. Yamamoto J, Ikeda Y, Iguchi H, Fujino T, Tanaka T, Asaba H, Iwasaki S, Ioka RX, Kaneko IW, Magoori K, Takahashi S, Mori T, Sakaue H, Kodama T, Yanagisawa M, Yamamoto TT, Ito S, Sakai J.J. Biol. Chem. 2004 Apr 23;279(17):16954-62. doi: 10.1074/jbc.M312079200 Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome. Tanaka T, Yamamoto J, Iwasaki S, Asaba H, Hamura H, Ikeda Y, Watanabe M, Magoori K, Ioka RX, Tachibana K, Watanabe Y, Uchiyama Y, Sumi K, Iguchi H, Ito S, Doi T, Hamakubo T, Naito M, Auwerx J, Yanagisawa M, Kodama T, Sakai J.Proc. Natl. Acad. Sci. U.S.A. 2003 Dec 23;100(26):15924-9. doi: 10.1073/pnas.0306981100 Pancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas development. Annicotte JS, Fayard E, Swift GH, Selander L, Edlund H, Tanaka T, Kodama T, Schoonjans K, Auwerx J.Mol. Cell. Biol. 2003 Oct;23(19):6713-24. doi: 10.1128/mcb.23.19.6713-6724.2003 PPARgamma coactivator 1beta/ERR ligand 1 is an ERR protein ligand, whose expression induces a high-energy expenditure and antagonizes obesity. Kamei Y, Ohizumi H, Fujitani Y, Nemoto T, Tanaka T, Takahashi N, Kawada T, Miyoshi M, Ezaki O, Kakizuka A.Proc. Natl. Acad. Sci. 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