Integrative Nutriomics and Oncology

Tsuyoshi OSAWA

PROFILE

2001-    BSc. Medical Biochemistry, King's College London
2010-    Ph.D., Cancer Institute, University College London
2006-    Researcher, Department of Genetics, Institute of Medical Science, The University of Tokyo (UTokyo)
2007-    Assistant Professor, Department of Oncology, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University
2011-    Research Associate, RCAST, UTokyo
2018-    Project Associate Professor, RCAST, UTokyo

FIELD OF INTEREST

Cancer research is entering a new era. We aimed to create novel cancer treatments through “Nutriomics” approach,the integration of nutrition and omics data. Carbohydrates, lipids and amino acids were independently considered in cancer. However, recent researches in cancer metabolism have been dramatically improved our metabolic knowledge due to latest understanding of cancer metabolism. Indeed, carbohydrates, lipids and amino acids are inter-connected in the metabolic pathways, through the several key metabolic molecules such as acetyl-CoA and ketone body intermediates partly under epigenetic regulation. Our group reported that hypoxia, nutrient starvation, acidic pH may induce tumor aggressiveness by epigenetic regulation in cancer cells. We found that multi-layered omics changes including epigenetic and metabolic changes influence cancer progression, that can be utilizes for the development of novel therapies by integration of genome, epigenome, transcriptome, proteome, metabolome analysis. Our research objectives:


1. To identify novel onco-metabolites (cancer associated metabolites) for the treatment of cancer.

2. To understand the mechanism of cancer adaptation in carbohydrate/lipids/amino acids deficiency and apply it to therapy.

3. Latest understanding of “nutriomics” for treatment of cancer. We challenge to develop therapeutics for metastasis and recurrent advanced cancer through the viewpoint of integrative “multi-layered omics” approach.


PUBLICATION