PUBLICATION

• Development of drug discovery screening system by molecular interaction kinetics-mass spectrometry. Obi N, Fukuda T, Nakayama N, Ervin J, Bando Y, Nishimura T, Nagatoishi S, Tsumoto K, Kawamura T.Rapid Commun. Mass Spectrom. 2018 Apr 30;32(8):665-671. doi: 10.1002/rcm.8083 Hierarchical roles of mitochondrial Papi and Zucchini in Bombyx germline piRNA biogenesis. Nishida KM, Sakakibara K, Iwasaki YW, Yamada H, Murakami R, Murota Y, Kawamura T, Kodama T, Siomi H, Siomi MC.Nature. 2018 03 08;555(7695):260-264. doi: 10.1038/nature25788 O-GlcNAc on PKCζ Inhibits the FGF4-PKCζ-MEK-ERK1/2 Pathway via Inhibition of PKCζ Phosphorylation in Mouse Embryonic Stem Cells. Miura T, Kume M, Kawamura T, Yamamoto K, Hamakubo T, Nishihara S.Stem Cell Reports. 2018 01 09;10(1):272-286. doi: 10.1016/j.stemcr.2017.11.007 Plasma Irradiation Effects to Intra-Abdominal Organ Compared with Adhesion Mouse Model. Keita Soda, Hiroharu Yamashita, Kyungho Chang, Takeshi Kawamura, Takao Hamakubo and Nobuyuki Shimizu.Plasma Medicine. 2017, 7(4):347–381 Degradation of human Lipin-1 by BTRC E3 ubiquitin ligase. Ishimoto K, Hayase A, Kumagai F, Kawai M, Okuno H, Hino N, Okada Y, Kawamura T, Tanaka T, Hamakubo T, Sakai J, Kodama T, Tachibana K, Doi T.Biochem. Biophys. Res. Commun. 2017 06 17;488(1):159-164. doi: 10.1016/j.bbrc.2017.04.159 Cooperative gene activation by AF4 and DOT1L drives MLL-rearranged leukemia. Okuda H, Stanojevic B, Kanai A, Kawamura T, Takahashi S, Matsui H, Takaori-Kondo A, Yokoyama A.J. Clin. Invest. 2017 May 01;127(5):1918-1931. doi: 10.1172/JCI91406 Biological implications of somatic DDX41 p.R525H mutation in acute myeloid leukemia. Kadono M, Kanai A, Nagamachi A, Shinriki S, Kawata J, Iwato K, Kyo T, Oshima K, Yokoyama A, Kawamura T, Nagase R, Inoue D, Kitamura T, Inaba T, Ichinohe T, Matsui H.Exp. Hematol. 2016 08;44(8):745-754.e4. doi: 10.1016/j.exphem.2016.04.017 PGE2 induced in and released by dying cells functions as an inhibitory DAMP. Hangai S, Ao T, Kimura Y, Matsuki K, Kawamura T, Negishi H, Nishio J, Kodama T, Taniguchi T, Yanai H.Proc. Natl. Acad. Sci. U.S.A. 2016 Apr 05;113(14):3844-9. doi: 10.1073/pnas.1602023113 Epiregulin Recognition Mechanisms by Anti-epiregulin Antibody 9E5: STRUCTURAL, FUNCTIONAL, AND MOLECULAR DYNAMICS SIMULATION ANALYSES. Kado Y, Mizohata E, Nagatoishi S, Iijima M, Shinoda K, Miyafusa T, Nakayama T, Yoshizumi T, Sugiyama A, Kawamura T, Lee YH, Matsumura H, Doi H, Fujitani H, Kodama T, Shibasaki Y, Tsumoto K, Inoue T.J. Biol. Chem. 2016 Jan 29;291(5):2319-30. doi: 10.1074/jbc.M115.656009 Analysis of the subcellular localization of the human histone methyltransferase SETDB1. Tachibana K, Gotoh E, Kawamata N, Ishimoto K, Uchihara Y, Iwanari H, Sugiyama A, Kawamura T, Mochizuki Y, Tanaka T, Sakai J, Hamakubo T, Kodama T, Doi T.Biochem. Biophys. Res. Commun. 2015 Oct 02;465(4):725-31. doi: 10.1016/j.bbrc.2015.08.065 JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis. Abe Y, Rozqie R, Matsumura Y, Kawamura T, Nakaki R, Tsurutani Y, Tanimura-Inagaki K, Shiono A, Magoori K, Nakamura K, Ogi S, Kajimura S, Kimura H, Tanaka T, Fukami K, Osborne TF, Kodama T, Aburatani H, Inagaki T, Sakai J.Nat Commun. 2015 May 07;6:7052. doi: 10.1038/ncomms8052 The FBXL10/KDM2B scaffolding protein associates with novel polycomb repressive complex-1 to regulate adipogenesis. Inagaki T, Iwasaki S, Matsumura Y, Kawamura T, Tanaka T, Abe Y, Yamasaki A, Tsurutani Y, Yoshida A, Chikaoka Y, Nakamura K, Magoori K, Nakaki R, Osborne TF, Fukami K, Aburatani H, Kodama T, Sakai J.J. Biol. Chem. 2015 Feb 13;290(7):4163-77. doi: 10.1074/jbc.M114.626929 Clinical initiatives linking Japanese and Swedish healthcare resources on cancer studies utilizing Biobank Repositories. Nishimura T, Kawamura T, Sugihara Y, Bando Y, Sakamoto S, Nomura M, Ikeda N, Ohira T, Fujimoto J, Tojo H, Hamakubo T, Kodama T, Andersson R, Fehniger TE, Kato H, Marko-Varga G.Clin Transl Med. 2014 Dec;3(1):61. doi: 10.1186/s40169-014-0038-x Direct evidence for pitavastatin induced chromatin structure change in the KLF4 gene in endothelial cells. Maejima T, Inoue T, Kanki Y, Kohro T, Li G, Ohta Y, Kimura H, Kobayashi M, Taguchi A, Tsutsumi S, Iwanari H, Yamamoto S, Aruga H, Dong S, Stevens JF, Poh HM, Yamamoto K, Kawamura T, Mimura I, Suehiro J, Sugiyama A, Kaneki K, Shibata H, Yoshinaka Y, Doi T, Asanuma A, Tanabe S, Tanaka T, Minami T, Hamakubo T, Sakai J, Nozaki N, Aburatani H, Nangaku M, Ruan X, Tanabe H, Ruan Y, Ihara S, Endo A, Kodama T, Wada Y.PLoS ONE. 2014;9(5):e96005. doi: 10.1371/journal.pone.0096005 MLL fusion proteins link transcriptional coactivators to previously active CpG-rich promoters. Okuda H, Kawaguchi M, Kanai A, Matsui H, Kawamura T, Inaba T, Kitabayashi I, Yokoyama A.Nucleic Acids Res. 2014 Apr;42(7):4241-56. doi: 10.1093/nar/gkt1394 Control of histone H3 lysine 9 (H3K9) methylation state via cooperative two-step demethylation by Jumonji domain containing 1A (JMJD1A) homodimer. Goda S, Isagawa T, Chikaoka Y, Kawamura T, Aburatani H.J. Biol. Chem. 2013 Dec 27;288(52):36948-56. doi: 10.1074/jbc.M113.492595 Identification of Wilms' tumor 1-associating protein complex and its role in alternative splicing and the cell cycle. Horiuchi K, Kawamura T, Iwanari H, Ohashi R, Naito M, Kodama T, Hamakubo T.J. Biol. Chem. 2013 Nov 15;288(46):33292-302. doi: 10.1074/jbc.M113.500397 Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication. Nishiyama A, Yamaguchi L, Sharif J, Johmura Y, Kawamura T, Nakanishi K, Shimamura S, Arita K, Kodama T, Ishikawa F, Koseki H, Nakanishi M.Nature. 2013 Oct 10;502(7470):249-53. doi: 10.1038/nature12488 Modification of p115RhoGEF Ser(330) regulates its RhoGEF activity. Chow CR, Suzuki N, Kawamura T, Hamakubo T, Kozasa T.Cell. Signal. 2013 Nov;25(11):2085-92. doi: 10.1016/j.cellsig.2013.06.012 Phosphatidylinositol 3-phosphatase myotubularin-related protein 6 (MTMR6) is regulated by small GTPase Rab1B in the early secretory and autophagic pathways. Mochizuki Y, Ohashi R, Kawamura T, Iwanari H, Kodama T, Naito M, Hamakubo T.J. Biol. Chem. 2013 Jan 11;288(2):1009-21. doi: 10.1074/jbc.M112.395087 Relationship between ATM and ribosomal protein S6 revealed by the chemical inhibition of Ser/Thr protein phosphatase type 1. Li Y, Mitsuhashi S, Ikejo M, Miura N, Kawamura T, Hamakubo T, Ubukata M.Biosci. Biotechnol. Biochem. 2012;76(3):486-94. doi: 10.1271/bbb.110774 The proteomic profile of circulating pentraxin 3 (PTX3) complex in sepsis demonstrates the interaction with azurocidin 1 and other components of neutrophil extracellular traps. Daigo K, Yamaguchi N, Kawamura T, Matsubara K, Jiang S, Ohashi R, Sudou Y, Kodama T, Naito M, Inoue K, Hamakubo T.Mol. Cell Proteomics. 2012 Jun;11(6):M111.015073. doi: 10.1074/mcp.M111.015073 Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. An FFPE proteomic study. Nomura M, Fukuda T, Fujii K, Kawamura T, Tojo H, Kihara M, Bando Y, Gazdar AF, Tsuboi M, Oshiro H, Nagao T, Ohira T, Ikeda N, Gotoh N, Kato H, Marko-Varga G, Nishimura T.J Clin Bioinforma. 2011 Sep 03;1(1):23. doi: 10.1186/2043-9113-1-23 A clinician view and experience of proteomic studies in the light of lung cancer in Japanese healthcare. Kato H, Nishimura T, Hirano T, Nomura M, Tojo H, Fujii K, Kawamura T, Mikami S, Kihara M, Bando Y, Tsuboi M, Ikeda N, Marko-Varga G.J. Proteome Res. 2011 Jan 07;10(1):51-7. doi: 10.1021/pr100859b TLS and PRMT1 synergistically coactivate transcription at the survivin promoter through TLS arginine methylation. Du K, Arai S, Kawamura T, Matsushita A, Kurokawa R.Biochem. Biophys. Res. Commun. 2011 Jan 28;404(4):991-6. doi: 10.1016/j.bbrc.2010.12.097 Proteomic analysis of native hepatocyte nuclear factor-4α (HNF4α) isoforms, phosphorylation status, and interactive cofactors. Daigo K, Kawamura T, Ohta Y, Ohashi R, Katayose S, Tanaka T, Aburatani H, Naito M, Kodama T, Ihara S, Hamakubo T.J. Biol. Chem. 2011 Jan 07;286(1):674-86. doi: 10.1074/jbc.M110.154732 Proteomic analysis of laser-microdissected paraffin-embedded tissues: (1) Stage-related protein candidates upon non-metastatic lung adenocarcinoma. Takeshi Kawamura*, Masaharu Nomura*, Hiromasa Tojo, Kiyonaga Fujii, Hiroko Hamasaki, Sayaka Mikami, Yasuhiko Bando, Harubumi Kato and Toshihide Nishimura (* equally contributed).J Proteomics. 2010 Apr 18;73(6):1089-99. Epub 2009 Nov 27. PMID: 19948256 Human ROBO1 is cleaved by metalloproteinases and gamma-secretase and migrates to the nucleus in cancer cells. Seki M, Watanabe A, Enomoto S, Kawamura T, Ito H, Kodama T, Hamakubo T, Aburatani H.FEBS Lett. 2010 Jul 02;584(13):2909-15. doi: 10.1016/j.febslet.2010.05.009 Annexin II represents metastatic potential in clear-cell renal cell carcinoma. Ohno Y, Izumi M, Kawamura T, Nishimura T, Mukai K, Tachibana M.Br. J. Cancer. 2009 Jul 21;101(2):287-94. doi: 10.1038/sj.bjc.6605128 Protein phosphatase Dusp26 associates with KIF3 motor and promotes N-cadherin-mediated cell-cell adhesion. Tanuma N, Nomura M, Ikeda M, Kasugai I, Tsubaki Y, Takagaki K, Kawamura T, Yamashita Y, Sato I, Sato M, Katakura R, Kikuchi K, Shima H.Oncogene. 2009 Feb 05;28(5):752-61. doi: 10.1038/onc.2008.431 Characterization and gene expression analysis of novel matched primary and metastatic renal cell carcinoma cell lines. Ohno Y, Izumi M, Tachibana M, Kawamura T, Yoshioka K, Aoyagi T, Ohori M, Namiki K, Sakamoto N, Nakagami Y, Hatano T, Akimoto S, Nishimura T.Oncol. Rep. 2008 Sep;20(3):501-9. Nuclear inhibitor of protein phosphatase-1 (NIPP1) directs protein phosphatase-1 (PP1) to dephosphorylate the U2 small nuclear ribonucleoprotein particle (snRNP) component, spliceosome-associated protein 155 (Sap155). Tanuma N, Kim SE, Beullens M, Tsubaki Y, Mitsuhashi S, Nomura M, Kawamura T, Isono K, Koseki H, Sato M, Bollen M, Kikuchi K, Shima H.J. Biol. Chem. 2008 Dec 19;283(51):35805-14. doi: 10.1074/jbc.M805468200 Alteration of cystatin C in the cerebrospinal fluid of multiple sclerosis. Nakashima I, Fujinoki M, Fujihara K, Kawamura T, Nishimura T, Nakamura M, Itoyama Y.Ann. Neurol. 2007 Aug;62(2):197-200; discussion 205. doi: 10.1002/ana.20955 Personalized medicine and proteomics: lessons from non-small cell lung cancer. Marko-Varga G, Ogiwara A, Nishimura T, Kawamura T, Fujii K, Kawakami T, Kyono Y, Tu HK, Anyoji H, Kanazawa M, Akimoto S, Hirano T, Tsuboi M, Nishio K, Hada S, Jiang H, Fukuoka M, Nakata K, Nishiwaki Y, Kunito H, Peers IS, Harbron CG, South MC, Higenbottam T, Nyberg F, Kudoh S, Kato H.J. Proteome Res. 2007 Aug;6(8):2925-35. doi: 10.1021/pr070046s Parkin interacts with LIM Kinase 1 and reduces its cofilin-phosphorylation activity via ubiquitination. Lim MK, Kawamura T, Ohsawa Y, Ohtsubo M, Asakawa S, Takayanagi A, Shimizu N.Exp. Cell Res. 2007 Aug 01;313(13):2858-74. doi: 10.1016/j.yexcr.2007.04.016 Multidimensional protein profiling technology and its application to human plasma proteome. Fujii K, Nakano T, Kawamura T, Usui F, Bando Y, Wang R, Nishimura T.J. Proteome Res. 3(4):712-8. doi: 10.1021/pr030007q Identification of 36 kDa phosphoprotein in fibrous sheath of hamster spermatozoa. Fujinoki M, Kawamura T, Toda T, Ohtake H, Ishimoda-Takagi T, Shimizu N, Yamaoka S, Okuno M.Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 2004 Apr;137(4):509-20. doi: 10.1016/j.cbpc.2004.02.006 Identification of the 58-kDa phosphoprotein associated with motility initiation of hamster spermatozoa. Fujinoki M, Kawamura T, Toda T, Ohtake H, Shimizu N, Yamaoka S, Okuno M.J. Biochem. 2003 Oct;134(4):559-65. doi: 10.1093/jb/mvg174 Identification of 66 kDa phosphoprotein associated with motility initiation of hamster spermatozoa. Fujinoki M, Kawamura T, Toda T, Ishimoda-Takagi T, Ohtake H, Shimizu N, Okuno M.Reprod. Med. Biol. 2004 Sep;3(3):133-139. doi: 10.1111/j.1447-0578.2004.00061.x Identification of 36-kDa flagellar phosphoproteins associated with hamster sperm motility. Fujinoki M, Kawamura T, Toda T, Ohtake H, Ishimoda-Takagi T, Shimizu N, Yamaoka S, Okuno M.J. Biochem. 2003 Mar;133(3):361-9. doi: 10.1093/jb/mvg048 Thyrsiferyl 23-acetate and its derivatives induce apoptosis in various T- and B-leukemia cells. Matsuzawa S, Kawamura T, Mitsuhashi S, Suzuki T, Matsuo Y, Suzuki M, Mizuno Y, Kikuchi K.Bioorg. Med. Chem. 1999 Feb;7(2):381-7. doi: 10.1016/s0968-0896(98)00226-0 The spiroketals containing a benzyloxymethyl moiety at C8 position showed the most potent apoptosis-inducing activity. Mitsuhashi S, Shima H, Kawamura T, Kikuchi K, Oikawa M, Ichihara A, Oikawa H.Bioorg. Med. Chem. Lett. 1999 Jul 19;9(14):2007-12. doi: 10.1016/s0960-894x(99)00309-1 Different moieties of tautomycin involved in protein phosphatase inhibition and induction of apoptosis. Kawamura T, Matsuzawa S, Mizuno Y, Kikuchi K, Oikawa H, Oikawa M, Ubukata M, Ichihara A.Biochem. Pharmacol. 1998 Apr 01;55(7):995-1003. doi: 10.1016/s0006-2952(97)00539-x Alterations in type-1 serine/threonine protein phosphatase PP1alpha in response to B-cell receptor stimulation. Takizawa N, Mizuno Y, Komatsu M, Matsuzawa S, Kawamura T, Inagaki N, Inagaki M, Kikuchi K.J. Biochem. 1997 Oct;122(4):730-7. doi: 10.1093/oxfordjournals.jbchem.a021816 Relationships of subunits of type-1 serine/threonine protein phosphatase to morphology and aggregation of B cells. Takizawa N, Komatsu M, Mizuno Y, Kawamura T, Ito M, Nakano T, Kikuchi K.J. Biochem. 1997 Oct;122(4):723-9. doi: 10.1093/oxfordjournals.jbchem.a021815 Thyrsiferyl 23-acetate is a novel specific inhibitor of protein phosphatase PP2A. Matsuzawa S, Suzuki T, Suzuki M, Matsuda A, Kawamura T, Mizuno Y, Kikuchi K.FEBS Lett. 1994 Dec 19;356(2-3):272-4. doi: 10.1016/0014-5793(94)01281-4 Increases in protein phosphatase 2B activity in lymphoid tissues and T-lymphocytes of autoimmune MRL/MpJ-lpr/lpr mice. Katagiri C, Kawamura T, Matsuzawa S, Mizuno Y, Matsumura S, Kikuchi K.J. Biochem. 1993 Dec;114(6):874-8. doi: 10.1093/oxfordjournals.jbchem.a124270