Skeltal muscles are responsible for the movement of our bodies and consume a lots of energy. Aging induces reduction in contraction force and muscle mass, fiber type shift to slow type, and fibrosis in skeletal muscle. These changes might result from instability of epigenome. We will clarify epigenetic mechanims in muscle cells during aging and aim to regulate sarcopenia by epigenome editing.
Sakakibara I, Fujino T, Ishii M, Tanaka T, Shimosawa T, Miura S, Zhang W, Tokutake Y, Yamamoto J, Awano M, Iwasaki S, Motoike T, Okamura M, Inagaki T, Kita K, Ezaki O, Naito M, Kuwaki T, Chohnan S, Yamamoto TT, Hammer RE, Kodama T, et al. Fasting-induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 2. Cell Metab. 2009 Feb;9(2):191-202. doi: 10.1016/j.cmet.2008.12.008.