Juro SAKAI
RESEARCH DIRECTIONS
Explore multi-modal and multi-layered biologyLABORATORY
http://www.mm.rcast.u-tokyo.ac.jp/PROFILE
1988- Graduated Tohoku University School of Medicine
1994- Graduated Graduate School of Medicine, Tohoku University School of Medicine
1994- Postdoctor Fellowship-University of Texas, Southwestern Medical Center
2000- Assistant professor, Tohoku University Graduate School of Medicine
2001- Group leader- Orphan Receptor Project, Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency (JST)
2003- Professor, Laboratory for Systems Biology and Medicine (LSBM), division of endocrinology and metabolism, RCAST, The University of TOKYO (UTokyo)
2009- Professor, LSBM, division of endocrinology and metabolism, RCAST, UTokyo
FIELD OF INTEREST
Metabolic syndrome causes cardiovascular disease or stroke at high frequency. Therefore the understanding of underlying mechanisms and effective therapies are badly needed. We identified several histone modification enzymes (HKMTs). Modification of histones by HKMTs can lead to suppression of gene expression due to addition of methyl groups. Our current research focuses on studying the link between energy imbalance and incorrect "epigenetic programming" due to inadequate maternal nutrition and/or metabolic disturbances in the development of obesity.
PUBLICATION
- H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-Specific DNA Methylation Pauses Adipocyte Differentiation. Matsumura Y, Nakaki R, Inagaki T, Yoshida A, Kano Y, Kimura H, Tanaka T, Tsutsumi S, Nakao M, Doi T, Fukami K, Osborne TF, Kodama T, Aburatani H, Sakai J.Mol. Cell. 2015 Nov 19;60(4):584-96. doi: 10.1016/j.molcel.2015.10.025 JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis. Abe Y, Rozqie R, Matsumura Y, Kawamura T, Nakaki R, Tsurutani Y, Tanimura-Inagaki K, Shiono A, Magoori K, Nakamura K, Ogi S, Kajimura S, Kimura H, Tanaka T, Fukami K, Osborne TF, Kodama T, Aburatani H, Inagaki T, Sakai J.Nat Commun. 2015 May 07;6:7052. doi: 10.1038/ncomms8052 The FBXL10/KDM2B scaffolding protein associates with novel polycomb repressive complex-1 to regulate adipogenesis. Inagaki T, Iwasaki S, Matsumura Y, Kawamura T, Tanaka T, Abe Y, Yamasaki A, Tsurutani Y, Yoshida A, Chikaoka Y, Nakamura K, Magoori K, Nakaki R, Osborne TF, Fukami K, Aburatani H, Kodama T, Sakai J.J. Biol. Chem. 2015 Feb 13;290(7):4163-77. doi: 10.1074/jbc.M114.626929