Expression of liver X receptor alpha and lipid metabolism in granulocyte-macrophage colony-stimulating factor-induced human monocyte-derived macrophage.

Kazawa T, Kawasaki T, Sakamoto A, Imamura M, Ohashi R, Jiang S, Tanaka T, Iwanari H, Hamakubo T, Sakai J, Kodama T, Naito M. Expression of liver X receptor alpha and lipid metabolism in granulocyte-macrophage colony-stimulating factor-induced human monocyte-derived macrophage. Pathol Int. 2009 Mar;59(3):152-60. doi: 10.1111/j.1440-1827.2009.02343.x.

Ets motifs are necessary for endothelial cell-specific expression of a 723-bp Tie-2 promoter/enhancer in Hprt targeted transgenic mice.

Kazawa T, Kawasaki T, Sakamoto A, Imamura M, Ohashi R, Jiang S, Tanaka T, Iwanari H, Hamakubo T, Sakai J, Kodama T, Naito M. Ets motifs are necessary for endothelial cell-specific expression of a 723-bp Tie-2 promoter/enhancer in Hprt targeted transgenic mice. Pathol Int. 2009 Mar;59(3):152-60. doi: 10.1111/j.1440-1827.2009.02343.x.

Design and synthesis of 4,6-di-tert-butyl-2,3-dihydro-5-benzofuranols as a novel series of antiatherogenic antioxidants.

Ushiku T, Uozaki H, Shinozaki A, Ota S, Matsuzaka K, Nomura S, Kaminishi M, Aburatani H, Kodama T, Fukayama M. Design and synthesis of 4,6-di-tert-butyl-2,3-dihydro-5-benzofuranols as a novel series of antiatherogenic antioxidants. Cancer Sci. 2009 Apr;100(4):626-32. doi: 10.1111/j.1349-7006.2009.01108.x. Epub 2009 Feb 19.

Hypoxia and low-nutrition double stress induces aggressiveness in a murine model of melanoma.

Osawa T, Muramatsu M, Watanabe M, Shibuya M. Hypoxia and low-nutrition double stress induces aggressiveness in a murine model of melanoma. Cancer Sci. 2009 May;100(5):844-51. doi: 10.1111/j.1349-7006.2009.01105.x. Epub 2009 Feb 10.

Fasting-induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 2.

Sakakibara I, Fujino T, Ishii M, Tanaka T, Shimosawa T, Miura S, Zhang W, Tokutake Y, Yamamoto J, Awano M, Iwasaki S, Motoike T, Okamura M, Inagaki T, Kita K, Ezaki O, Naito M, Kuwaki T, Chohnan S, Yamamoto TT, Hammer RE, Kodama T, et al. Fasting-induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 2. Cell Metab. 2009 Feb;9(2):191-202. doi: 10.1016/j.cmet.2008.12.008.

[Laboratory for systems biology and medicine at RCAST, University of Tokyo].

Minegishi Y, Iwanari H, Mochizuki Y, Horii T, Hoshino T, Kodama T, Hamakubo T, Gotoh N. [Laboratory for systems biology and medicine at RCAST, University of Tokyo]. FEBS Lett. 2009 Feb 18;583(4):807-14. doi: 10.1016/j.febslet.2009.01.042. Epub 2009 Jan 31.

Inhibition of THP-1 cell adhesion to endothelial cells by alpha-tocopherol and alpha-tocotrienol is dependent on intracellular concentration of the antioxidants.

Sakakibara I, Fujino T, Ishii M, Tanaka T, Shimosawa T, Miura S, Zhang W, Tokutake Y, Yamamoto J, Awano M, Iwasaki S, Motoike T, Okamura M, Inagaki T, Kita K, Ezaki O, Naito M, Kuwaki T, Chohnan S, Yamamoto TT, Hammer RE, Kodama T, et al. Inhibition of THP-1 cell adhesion to endothelial cells by alpha-tocopherol and alpha-tocotrienol is dependent on intracellular concentration of the antioxidants. Cell Metab. 2009 Feb;9(2):191-202. doi: 10.1016/j.cmet.2008.12.008.

Deficiency of cathepsin S reduces atherosclerosis in LDL receptor-deficient mice.

Takegoshi S, Jiang S, Ohashi R, Savchenko AS, Iwanari H, Tanaka T, Hasegawa G, Hamakubo T, Kodama T, Naito M. Deficiency of cathepsin S reduces atherosclerosis in LDL receptor-deficient mice. Pathol Int. 2009 Feb;59(2):61-72. doi: 10.1111/j.1440-1827.2008.02330.x.

Protein expression of nuclear receptors in human and murine tissues.

Takegoshi S, Jiang S, Ohashi R, Savchenko AS, Iwanari H, Tanaka T, Hasegawa G, Hamakubo T, Kodama T, Naito M. Protein expression of nuclear receptors in human and murine tissues. Pathol Int. 2009 Feb;59(2):61-72. doi: 10.1111/j.1440-1827.2008.02330.x.

Antioxidant action of 2,2,4,6-tetra-substituted 2,3-dihydro-5-hydroxybenzofuran against lipid peroxidation: effects of substituents and side chain.

Sakihama T, Sato T, Iwanari H, Kitamura T, Sakaguchi S, Kodama T, Hamakubo T. Antioxidant action of 2,2,4,6-tetra-substituted 2,3-dihydro-5-hydroxybenzofuran against lipid peroxidation: effects of substituents and side chain. PLoS One. 2008;3(12):e4024. doi: 10.1371/journal.pone.0004024. Epub 2008 Dec 24.

Thrombin stimulation of vascular adhesion molecule-1 in endothelial cells is mediated by protein kinase C (PKC)-delta-NF-kappa B and PKC-zeta-GATA signaling pathways.

Sako K, Fukuhara S, Minami T, Hamakubo T, Song H, Kodama T, Fukamizu A, Gutkind JS, Koh GY, Mochizuki N. Thrombin stimulation of vascular adhesion molecule-1 in endothelial cells is mediated by protein kinase C (PKC)-delta-NF-kappa B and PKC-zeta-GATA signaling pathways. J Biol Chem. 2009 Feb 27;284(9):5592-601. doi: 10.1074/jbc.M806928200. Epub 2008 Dec 23.

The class A scavenger receptor binds to proteoglycans and mediates adhesion of macrophages to the extracellular matrix.

Suzuki N, Tsumoto K, Hajicek N, Daigo K, Tokita R, Minami S, Kodama T, Hamakubo T, Kozasa T. The class A scavenger receptor binds to proteoglycans and mediates adhesion of macrophages to the extracellular matrix. J Biol Chem. 2009 Feb 20;284(8):5000-9. doi: 10.1074/jbc.M804073200. Epub 2008 Dec 12.

Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts.

Yanagimoto S, Tatsuno K, Okugawa S, Kitazawa T, Tsukada K, Koike K, Kodama T, Kimura S, Shibasaki Y, Ota Y. Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. J Biol Chem. 2009 Feb 6;284(6):3513-20. doi: 10.1074/jbc.M803086200. Epub 2008 Dec 8.

The class A macrophage scavenger receptor is a major pattern recognition receptor for Neisseria meningitidis which is independent of lipopolysaccharide and not required for secretory responses.

Ishiguro T, Sugimoto M, Kinoshita Y, Miyazaki Y, Nakano K, Tsunoda H, Sugo I, Ohizumi I, Aburatani H, Hamakubo T, Kodama T, Tsuchiya M, Yamada-Okabe H. The class A macrophage scavenger receptor is a major pattern recognition receptor for Neisseria meningitidis which is independent of lipopolysaccharide and not required for secretory responses. Cancer Res. 2008 Dec 1;68(23):9832-8. doi: 10.1158/0008-5472.CAN-08-1973.

Subcellular localization of HCV core protein regulates its ability for p53 activation and p21 suppression.

Nakano K, Orita T, Nezu J, Yoshino T, Ohizumi I, Sugimoto M, Furugaki K, Kinoshita Y, Ishiguro T, Hamakubo T, Kodama T, Aburatani H, Yamada-Okabe H, Tsuchiya M. Subcellular localization of HCV core protein regulates its ability for p53 activation and p21 suppression. Biochem Biophys Res Commun. 2009 Jan 9;378(2):279-84. doi: 10.1016/j.bbrc.2008.11.033. Epub 2008 Nov 18.

Measurement of HCV RdRp activity with C-terminal 21 aa truncated NS5b protein: optimization of assay conditions.

Yoneda M, Uchiyama T, Kato S, Endo H, Fujita K, Yoneda K, Mawatari H, Iida H, Takahashi H, Kirikoshi H, Inamori M, Nozaki Y, Kobayashi N, Kubota K, Saito S, Maeyama S, Sagara M, Aburatani H, Kodama T, Nakajima A. Measurement of HCV RdRp activity with C-terminal 21 aa truncated NS5b protein: optimization of assay conditions. BMC Gastroenterol. 2008 Nov 14;8:53. doi: 10.1186/1471-230X-8-53.