Development of Drug Discovery Screening System by Molecular Interaction Kinetics Mass Spectrometry.

Obi N, Fukuda T, Nakayama N, Ervin J, Bando Y, Nishimura T, Nagatoishi S, Tsumoto K, Kawamura T. Development of Drug Discovery Screening System by Molecular Interaction Kinetics Mass Spectrometry. Rapid Commun Mass Spectrom. 2018 Feb 14. doi: 10.1002/rcm.8083. [Epub ahead of print] PMID: 29441684

Hierarchical roles of mitochondrial Papi and Zucchini in Bombyx germline piRNA biogenesis.

Nishida KM, Sakakibara K, Iwasaki YW, Yamada H, Murakami R, Murota Y, Kawamura T, Kodama T, Siomi H, Siomi MC. Hierarchical roles of mitochondrial Papi and Zucchini in Bombyx germline piRNA biogenesis. Nature. 2018 Mar 8;555(7695):260-264. doi: 10.1038/nature25788. Epub 2018 Feb 28. PMID: 29489748

Plasma Irradiation Effects to Intra-Abdominal Organ Compared with Adhesion Mouse Model.

Keita Soda, Hiroharu Yamashita, Kyungho Chang, Takeshi Kawamura, Takao Hamakubo and Nobuyuki Shimizu. Plasma Irradiation Effects to Intra-Abdominal Organ Compared with Adhesion Mouse Model. Plasma Medicine 2017, 7(4):347–381

Cooperative gene activation by AF4 and DOT1L drives MLL-rearranged leukemia.

Hiroshi Okuda, Boban Stanojevic, Akinori Kanai, Takeshi Kawamura, Satoshi Takahashi, Hirotaka Matsui, Akifumi Takaori-Kondo, Akihiko Yokoyama. Cooperative gene activation by AF4 and DOT1L drives MLL-rearranged leukemia. The Journal of Clinical Investegation 2017 May 1;127(5):1918-1931. doi: 10.1172/JCI91406. Epub 2017 Apr 10.

O-GlcNAc on PKCζ Inhibits the FGF4-PKCζ-MEK-ERK1/2 Pathway via Inhibition of PKCζ Phosphorylation in Mouse Embryonic Stem Cells.

Taichi Miura, Masahiko Kume, Takeshi Kawamura, Kazuo Yamamoto, Takao Hamakubo, and Shoko Nishihara. O-GlcNAc on PKCζ Inhibits the FGF4-PKCζ-MEK-ERK1/2 Pathway via Inhibition of PKCζ Phosphorylation in Mouse Embryonic Stem Cells. Stem Cell Reports. 2017 Dec 12. pii: S2213-6711(17)30514-3. doi: 10.1016/j.stemcr.2017.11.007.

Biological implications of somatic DDX41 p.R525H mutation in acute myeloid leukemia.

Kadono M, Kanai A, Nagamachi A, Shinriki S, Kawata J, Iwato K, Kyo T, Oshima K, Yokoyama A, Kawamura T, Nagase R, Inoue D, Kitamura T, Inaba T, Ichinohe T, Matsui H. Biological implications of somatic DDX41 p.R525H mutation in acute myeloid leukemia. Exp Hematol. 2016 Aug;44(8):745-754.e4. doi: 10.1016/j.exphem.2016.04.017. Epub 2016 May 9. PMID: 27174803

MLL fusion proteins link transcriptional coactivators to previously active CpG-rich promoters.

Okuda H, Kawaguchi M, Kanai A, Matsui H, Kawamura T, Inaba T, Kitabayashi I, Yokoyama A. MLL fusion proteins link transcriptional coactivators to previously active CpG-rich promoters. Nucleic Acids Res. 2014 Apr;42(7):4241-56. doi: 10.1093/nar/gkt1394. Epub 2014 Jan 23. PMID: 24465000

Modification of p115RhoGEF Ser330 regulates its RhoGEF activity.

Chow CR, Suzuki N, Kawamura T, Hamakubo T, Kozasa T. Modification of p115RhoGEF Ser330 regulates its RhoGEF activity. Cell Signal. 2013 Nov;25(11):2085-92. doi: 10.1016/j.cellsig.2013.06.012. Epub 2013 Jun 29. PMID: 23816534

Uhrf1-dependent ubiquitylation of histone H3 at lysine 23 couples maintenance DNA methylation and DNA replication.

Atsuya Nishiyama, Luna Yamaguchi1 Jafar Sharif, Yoshikazu Johmura, Takeshi Kawamura, Keiko Nakanishi, Shintaro Shimamura, Tatsuhiko Kodama, Fuyuki Ishikawa, Haruhiko Koseki and Makoto Nakanishi Uhrf1-dependent ubiquitylation of histone H3 at lysine 23 couples maintenance DNA methylation and DNA replication. Nature (2013) Oct 10;502(7470):249-253. doi: 10.1038/nature12488. Epub 2013 Sep 8. PMID: 24013172

TLS and PRMT1 synergistically coactivate transcription at the survivin promoter through TLS arginine methylation.

Kun Du, Shigeki Arai, Takeshi Kawamura, Akio Matsushita, Riki Kurokawa. TLS and PRMT1 synergistically coactivate transcription at the survivin promoter through TLS arginine methylation. Biochem Biophys Res Commun. 2011 Jan 28;404(4):991-6. Epub 2010 Dec 25.

Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. An FFPE proteomic study.

Nomura M, Fukuda T, Fujii K, Kawamura T, Tojo H, Kihara M, Bando Y, Gazdar AF, Tsuboi M, Oshiro H, Nagao T, Ohira T, Ikeda N, Gotoh N, Kato H, Marko-Varga G, Nishimura T. Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. An FFPE proteomic study. J Clin Bioinforma. 2011 Sep 3;1(1):23.PMID: 21888658

Proteomic analysis of laser-microdissected paraffin-embedded tissues: (1) Stage-related protein candidates upon non-metastatic lung adenocarcinoma.

Takeshi Kawamura*, Masaharu Nomura*, Hiromasa Tojo, Kiyonaga Fujii, Hiroko Hamasaki, Sayaka Mikami, Yasuhiko Bando, Harubumi Kato and Toshihide Nishimura (* equally contributed). Proteomic analysis of laser-microdissected paraffin-embedded tissues: (1) Stage-related protein candidates upon non-metastatic lung adenocarcinoma. J Proteomics. 2010 Apr 18;73(6):1089-99. Epub 2009 Nov 27. PMID: 19948256

Human ROBO1 Is Cleaved by Metalloproteinases and g-Secretase and Migrates to the Nucleus in Cancer Cells.

Motoaki Seki, Akira Watanabe, Satoshi Enomoto, Takeshi Kawamura, Hirotaka Ito, Tatsuhiko Kodama, Takao Hamakubo and Hiroyuki Aburatani Human ROBO1 Is Cleaved by Metalloproteinases and g-Secretase and Migrates to the Nucleus in Cancer Cells. FEBS letter. 2010 Jul 2;584(13):2909-15. Epub 2010 May 13. PMID: 20471383

A Clinician View of Proteomic Studies in the Light of the Experience in the Lung Cancer in Japanese Healthcare.

Kato H, Nishimura T, Hirano T, Nomura M, Tojo H, Fujii K, Kawamura T, Mikami S, Kihara M, Bando Y, Tsuboi M, Ikeda N, Varga GM. A Clinician View of Proteomic Studies in the Light of the Experience in the Lung Cancer in Japanese Healthcare. J Proteome Res. 2010 Dec 8. Epub 2011 Jan 7;10(1):51-7.

Protein phosphatase Dusp26 associates with KIF3 motor and promotes N-cadherin-mediated cell-cell adhesion.

Tanuma N, Nomura M, Ikeda M, Kasugai I, Tsubaki Y, Takagaki K, Kawamura T, Yamashita Y, Sato I, Sato M, Katakura R, Kikuchi K, Shima H. Protein phosphatase Dusp26 associates with KIF3 motor and promotes N-cadherin-mediated cell-cell adhesion. Oncogene. 2009 Feb 5;28(5):752-61. Epub 2008 Dec 1. PMID: 19043453

Annexin II represents metastatic potential in clear-cell renal cell carcinoma.

Ohno Y, Izumi M, Kawamura T, Nishimura T, Mukai K, Tachibana M. Annexin II represents metastatic potential in clear-cell renal cell carcinoma. Br J Cancer. 2009 Jul 21;101(2):287-94. Epub 2009 Jun 9.PMID: 19513064