What consequence is anticipated by the emergence of novel SPPARMa agent developed so as to achieve an improved safety/efficacy balance?

Motonobu Anai, Toshiya Tanaka, Tatsuhiko Kodama. What consequence is anticipated by the emergence of novel SPPARMa agent developed so as to achieve an improved safety/efficacy balance? Jpn Pharmacol. Ther., 46: 471-480 (2018).