Mechanism of cell death resulting from DNA interstrand cross-linking in mammalian cells.

Osawa T, Davies D, Hartley JA. Mechanism of cell death resulting from DNA interstrand cross-linking in mammalian cells. Cell Death Dis. 2011 Aug 4;2:e187. doi: 10.1038/cddis.2011.70.

DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response.

Yoshimatsu Y, Yamazaki T, Mihira H, Itoh T, Suehiro J, Yuki K, Harada K, Morikawa M, Iwata C, Minami T, Morishita Y, Kodama T, Miyazono K, Watabe T. DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. J Cell Sci. 2011 Aug 15;124(Pt 16):2753-62. doi: 10.1242/jcs.083998.

Proteomic analysis of native hepatocyte nuclear factor-4α (HNF4α) isoforms, phosphorylation status, and interactive cofactors.

Daigo K, Kawamura T, Ohta Y, Ohashi R, Katayose S, Tanaka T, Aburatani H, Naito M, Kodama T, Ihara S, Hamakubo T. Proteomic analysis of native hepatocyte nuclear factor-4α (HNF4α) isoforms, phosphorylation status, and interactive cofactors. J Biol Chem. 2011 Jan 7;286(1):674-86. doi: 10.1074/jbc.M110.154732. Epub 2010 Nov 3. Erratum in: J Biol Chem. 2013 Aug 16;288(33):24161.

Fenofibrate suppresses growth of the human hepatocellular carcinoma cell via PPARα-independent mechanisms.

Yamasaki D, Kawabe N, Nakamura H, Tachibana K, Ishimoto K, Tanaka T, Aburatani H, Sakai J, Hamakubo T, Kodama T, Doi T. Fenofibrate suppresses growth of the human hepatocellular carcinoma cell via PPARα-independent mechanisms. Eur J Cell Biol. 2011 Aug;90(8):657-64. doi: 10.1016/j.ejcb.2011.02.005. Epub 2011 Apr 21.

ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif.

Morikawa M, Koinuma D, Tsutsumi S, Vasilaki E, Kanki Y, Heldin CH, Aburatani H, Miyazono K. ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif. Nucleic Acids Res. 2011 Nov 1;39(20):8712-27. doi: 10.1093/nar/gkr572. Epub 2011 Jul 15.

Homozygously deleted gene DACH1 regulates tumor-initiating activity of glioma cells.

Watanabe A, Ogiwara H, Ehata S, Mukasa A, Ishikawa S, Maeda D, Ueki K, Ino Y, Todo T, Yamada Y, Fukayama M, Saito N, Miyazono K, Aburatani H. Homozygously deleted gene DACH1 regulates tumor-initiating activity of glioma cells. Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12384-9. doi: 10.1073/pnas.0906930108. Epub 2011 Jul 12.

ASCL1-coexpression profiling but not single gene expression profiling defines lung adenocarcinomas of neuroendocrine nature with poor prognosis.

Fujiwara T, Hiramatsu M, Isagawa T, Ninomiya H, Inamura K, Ishikawa S, Ushijima M, Matsuura M, Jones MH, Shimane M, Nomura H, Ishikawa Y, Aburatani H. ASCL1-coexpression profiling but not single gene expression profiling defines lung adenocarcinomas of neuroendocrine nature with poor prognosis. Lung Cancer. 2012 Jan;75(1):119-25. doi: 10.1016/j.lungcan.2011.05.028. Epub 2011 Jul 6.

Epigenetic regulation of osteoclast differentiation: possible involvement of Jmjd3 in the histone demethylation of Nfatc1.

Yasui T, Hirose J, Tsutsumi S, Nakamura K, Aburatani H, Tanaka S. Epigenetic regulation of osteoclast differentiation: possible involvement of Jmjd3 in the histone demethylation of Nfatc1. J Bone Miner Res. 2011 Nov;26(11):2665-71. doi: 10.1002/jbmr.464.

Gene expression profiling of mouse growth plate cartilage by laser microdissection and microarray analysis.

Isshiki H, Sato K, Horiuchi K, Tsutsumi S, Kano M, Ikegami H, Abe H, Umezawa A, Aburatani H, Toyama Y. Gene expression profiling of mouse growth plate cartilage by laser microdissection and microarray analysis. J Orthop Sci. 2011 Sep;16(5):670-2. doi: 10.1007/s00776-011-0119-2. Epub 2011 Jul 1. No abstract available.

Pathological role of osteoclast costimulation in arthritis-induced bone loss.

Idrus E, Nakashima T, Wang L, Hayashi M, Okamoto K, Kodama T, Tanaka N, Taniguchi T, Takayanagi H. Pathological role of osteoclast costimulation in arthritis-induced bone loss. Biochem Biophys Res Commun. 2011 Jul 8;410(3):620-5. doi: 10.1016/j.bbrc.2011.06.040. Epub 2011 Jun 13.

Epigenetically coordinated GATA2 binding is necessary for endothelium-specific endomucin expression.

Kanki Y, Kohro T, Jiang S, Tsutsumi S, Mimura I, Suehiro J, Wada Y, Ohta Y, Ihara S, Iwanari H, Naito M, Hamakubo T, Aburatani H, Kodama T, Minami T. Epigenetically coordinated GATA2 binding is necessary for endothelium-specific endomucin expression. EMBO J. 2011 Jun 10;30(13):2582-95. doi: 10.1038/emboj.2011.173.

Gab family proteins are essential for postnatal maintenance of cardiac function via neuregulin-1/ErbB signaling.

Kanki Y, Kohro T, Jiang S, Tsutsumi S, Mimura I, Suehiro J, Wada Y, Ohta Y, Ihara S, Iwanari H, Naito M, Hamakubo T, Aburatani H, Kodama T, Minami T. Gab family proteins are essential for postnatal maintenance of cardiac function via neuregulin-1/ErbB signaling. EMBO J. 2011 Jun 10;30(13):2582-95. doi: 10.1038/emboj.2011.173.

Cell type-specific target selection by combinatorial binding of Smad2/3 proteins and hepatocyte nuclear factor 4alpha in HepG2 cells.

Mizutani A, Koinuma D, Tsutsumi S, Kamimura N, Morikawa M, Suzuki HI, Imamura T, Miyazono K, Aburatani H. Cell type-specific target selection by combinatorial binding of Smad2/3 proteins and hepatocyte nuclear factor 4alpha in HepG2 cells. J Biol Chem. 2011 Aug 26;286(34):29848-60. doi: 10.1074/jbc.M110.217745. Epub 2011 Jun 6.

Methylation screening of reciprocal genome-wide UPDs identifies novel human-specific imprinted genes.

Nakabayashi K, Trujillo AM, Tayama C, Camprubi C, Yoshida W, Lapunzina P, Sanchez A, Soejima H, Aburatani H, Nagae G, Ogata T, Hata K, Monk D. Methylation screening of reciprocal genome-wide UPDs identifies novel human-specific imprinted genes. Hum Mol Genet. 2011 Aug 15;20(16):3188-97. doi: 10.1093/hmg/ddr224. Epub 2011 May 18.

A method of generating antibodies against exogenously administered self-antigen by manipulating CD4+CD25+ regulatory T cells.

Iwanari H, Nakada-Nakura Y, Kusano-Arai O, Suzuki N, Kodama T, Sakihama T, Hamakubo T. A method of generating antibodies against exogenously administered self-antigen by manipulating CD4+CD25+ regulatory T cells. J Immunol Methods. 2011 Jun 30;369(1-2):108-14. doi: 10.1016/j.jim.2011.04.011. Epub 2011 May 3.

Targeted deletion of class A macrophage scavenger receptor increases the risk of cardiac rupture after experimental myocardial infarction.

Iwanari H, Nakada-Nakura Y, Kusano-Arai O, Suzuki N, Kodama T, Sakihama T, Hamakubo T. Targeted deletion of class A macrophage scavenger receptor increases the risk of cardiac rupture after experimental myocardial infarction. J Immunol Methods. 2011 Jun 30;369(1-2):108-14. doi: 10.1016/j.jim.2011.04.011. Epub 2011 May 3.