Presenter: Nozomu Yachie
Affiliation: The University of British Columbia
Date: Apr. 18th
2022.04.14
4/18, LSBM Monday Seminar Series #16, Nozomu Yachie, HD Video Recorder of the Cell
Title: HD Video Recorder of the Cell
Abstract
The dynamic behaviors of cells during development, tumorigenesis, and other disorders remain largely unclear. Our lab is developing “DNA event recording” systems by which high-resolution information of cells is progressively stored in cell-embedded “DNA tapes.” Using high-throughput single-cell sequencing, such a system enables access to molecular and cellular history information of cells at the time of observation and provides a way of observing the dynamics of complex biological systems in high resolution. We envision mapping the whole-body cell lineage and differentiation trajectories of mouse development and have been actively progressing towards this goal. I will share our grant vision and recent progresses in developing new genome editing tools and high-performance computing technologies.