11/1, LSBM Monday Seminar Series #12, Takashi Satoh, Research of disorder specific macrophage subtypes -Towards understanding the mechanism of fibrosis onset-

Presenter: Takashi Satoh (Department of Immune Regulation, Graduate school of Medical and Dental Sciences, Tokyo
Medical and Dental University (TMDU))

Date: November 1st (Mon.) 12PM~

【Title】

Research of disorder specific macrophage subtypes

-Towards understanding the mechanism of fibrosis onset-

【Abstract】

Macrophages have been discovered more than 100 years ago. Recent studies indicated that monocytes and macrophages can be categorized into several distinct phenotypes and their respective differentiation mechanisms are known. We also reported that the Jmjd3 is critical for the macrophage subtype activated by allergic stimuli (1) and that the tissue resident macrophage subtype in adipose tissue, which is controlled by Trib1, is responsible for maintaining homeostasis of peripheral tissues such as adipocyte (2). Thus, it is considered that various macrophage/monocyte subtypes corresponding to certain disorders were existed in our body.

Furthermore, in order to investigate the relationship between macrophage subtype and disease, we focused on fibrosis as the next target disease. Its pathogenesis is poorly understood, and there are few effective therapies. Previously we found that a new macrophage/monocyte subtype, which their markers are Msr1⁺Ceacam1⁺Ly6C^–Mac1⁺F4/80^–monocyte and share granulocyte characteristics, involved in development of fibrosis was accumulated in the affected area in the lungs at the beginning of fibrosis. We termed the monocyte/ macrophage subtype segregated-nucleus-containing atypical monocytes (SatM) (3). Towards understanding the mechanism of fibrosis onset, we next focused on investigation of non-haematopoietic cells involved in activation of immune cell such as SatM during fibrotic phase (4). In this conference, we will talk about it.

References:

(1)          Satoh T., et al, Nat Immunol. 2010 Oct;11(10):936-44.

(2)          Satoh T., et al, Nature. 2013 Mar 28;495(7442):524-8.

(3)          Satoh T., et al, Nature. 2017 Jan 5;541(7635):96-101

(4) 　　 Fukushima K^*., Satoh T^*., et al Immunity. 2020 Mar 17;52(3):542-556.

【Affiliation】

Department of Immune Regulation, Graduate school of Medical and Dental Sciences, Tokyo

Medical and Dental University (TMDU)

【Profile】

March 2010 Ph.D. laboratory of host defense (Dr. Shizuo Akira lab), IFREC, Osaka University.

April 2010- March 2012 Post-doctoral fellow, laboratory of host defense, RIMD, Osaka

University

April 2012- March 2017 Assistant Professor, laboratory of host defense, RIMD, Osaka

University

April 2017-June 2020 Associate Professor, laboratory of host defense, RIMD, Osaka

University

July 2021- Professor, Immune regulation, Graduate school of Medical and Dental Sciences,

Tokyo Medical and Dental University (TMDU)