Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer.

Fujimoto A, Furuta M, Totoki Y, Tsunoda T, Kato M, Shiraishi Y, Tanaka H, Taniguchi H, Kawakami Y, Ueno M, Gotoh K, Ariizumi S, Wardell CP, Hayami S, Nakamura T, Aikata H, Arihiro K, Boroevich KA, Abe T, Nakano K, Maejima K, Sasaki-Oku A, et al. Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer. Nat Genet. 2016 May;48(5):500-9. doi: 10.1038/ng.3547. Epub 2016 Apr 11.

PGE2 induced in and released by dying cells functions as an inhibitory DAMP.

Hangai S, Ao T, Kimura Y, Matsuki K, Kawamura T, Negishi H, Nishio J, Kodama T, Taniguchi T, Yanai H. PGE2 induced in and released by dying cells functions as an inhibitory DAMP. Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):3844-9. doi: 10.1073/pnas.1602023113.

MEIS1-mediated transactivation of synaptotagmin-like 1 promotes CXCL12/CXCR4 signaling and leukemogenesis.

Yokoyama T, Nakatake M, Kuwata T, Couzinet A, Goitsuka R, Tsutsumi S, Aburatani H, Valk PJ, Delwel R, Nakamura T. MEIS1-mediated transactivation of synaptotagmin-like 1 promotes CXCL12/CXCR4 signaling and leukemogenesis. J Clin Invest. 2016 May 2;126(5):1664-78. doi: 10.1172/JCI81516. Epub 2016 Mar 28.

Fezf2 Orchestrates a Thymic Program of Self-Antigen Expression for Immune Tolerance.

Hangai S, Ao T, Kimura Y, Matsuki K, Kawamura T, Negishi H, Nishio J, Kodama T, Taniguchi T, Yanai H. Fezf2 Orchestrates a Thymic Program of Self-Antigen Expression for Immune Tolerance. Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):3844-9. doi: 10.1073/pnas.1602023113. Epub 2016 Mar 21.

Novel p53 target gene FUCA1 encodes a fucosidase and regulates growth and survival of cancer cells.

Ezawa I, Sawai Y, Kawase T, Okabe A, Tsutsumi S, Ichikawa H, Kobayashi Y, Tashiro F, Namiki H, Kondo T, Semba K, Aburatani H, Taya Y, Nakagama H, Ohki R. Novel p53 target gene FUCA1 encodes a fucosidase and regulates growth and survival of cancer cells. Cancer Sci. 2016 Jun;107(6):734-45. doi: 10.1111/cas.12933. Epub 2016 May 16.

Epigenetic alteration to activate Bmp2-Smad signaling in Raf-induced senescence.

Fujimoto M, Mano Y, Anai M, Yamamoto S, Fukuyo M, Aburatani H, Kaneda A. Epigenetic alteration to activate Bmp2-Smad signaling in Raf-induced senescence. World J Biol Chem. 2016 Feb 26;7(1):188-205. doi: 10.4331/wjbc.v7.i1.188.

Integrated Multiregional Analysis Proposing a New Model of Colorectal Cancer Evolution.

Uchi R, Takahashi Y, Niida A, Shimamura T, Hirata H, Sugimachi K, Sawada G, Iwaya T, Kurashige J, Shinden Y, Iguchi T, Eguchi H, Chiba K, Shiraishi Y, Nagae G, Yoshida K, Nagata Y, Haeno H, Yamamoto H, Ishii H, Doki Y, Iinuma H, et al. Integrated Multiregional Analysis Proposing a New Model of Colorectal Cancer Evolution. PLoS Genet. 2016 Feb 18;12(2):e1005778. doi: 10.1371/journal.pgen.1005778. eCollection 2016 Feb.

SCF(Fbxo22)-KDM4A targets methylated p53 for degradation and regulates senescence.

Johmura Y, Sun J, Kitagawa K, Nakanishi K, Kuno T, Naiki-Ito A, Sawada Y, Miyamoto T, Okabe A, Aburatani H, Li S, Miyoshi I, Takahashi S, Kitagawa M, Nakanishi M. SCF(Fbxo22)-KDM4A targets methylated p53 for degradation and regulates senescence. Nat Commun. 2016 Feb 12;7:10574. doi: 10.1038/ncomms10574.

A proteomic profiling of laser-microdissected lung adenocarcinoma cells of early lepidic-types.

Yamamoto K, Chikaoka Y, Hayashi G, Sakamoto R, Yamamoto R, Sugiyama A, Kodama T, Okamoto A, Kawamura T. A proteomic profiling of laser-microdissected lung adenocarcinoma cells of early lepidic-types. Mass Spectrom (Tokyo). 2015;4(1):A0039. doi: 10.5702/massspectrometry.A0039. Epub 2015 Jul 14.

Biological characterization of soft tissue sarcomas.

Hayashi T, Horiuchi A, Sano K, Kanai Y, Yaegashi N, Aburatani H, Konishi I. Biological characterization of soft tissue sarcomas. Ann Transl Med. 2015 Dec;3(22):368. doi: 10.3978/j.issn.2305-5839.2015.12.33.

An improvement on mass spectrometry-based epigenetic analysis of large histone-derived peptides by using the Ionization Variable Unit interface.

Katsura M, Cyou-Nakamine H, Zen Q, Zen Y, Nansai H, Amagasa S, Kanki Y, Inoue T, Kaneki K, Taguchi A, Kobayashi M, Kaji T, Kodama T, Miyagawa K, Wada Y, Akimitsu N, Sone H. An improvement on mass spectrometry-based epigenetic analysis of large histone-derived peptides by using the Ionization Variable Unit interface. Sci Rep. 2016 Jan 22;6:20027. doi: 10.1038/srep20027.

Identification of Novel HLA-A*24:02-Restricted Epitope Derived from a Homeobox Protein Expressed in Hematological Malignancies.

Matsushita M, Otsuka Y, Tsutsumida N, Tanaka C, Uchiumi A, Ozawa K, Suzuki T, Ichikawa D, Aburatani H, Okamoto S, Kawakami Y, Hattori Y. Identification of Novel HLA-A*24:02-Restricted Epitope Derived from a Homeobox Protein Expressed in Hematological Malignancies. PLoS One. 2016 Jan 19;11(1):e0146371. doi: 10.1371/journal.pone.0146371. eCollection 2016.

Genomic characterization of primary central nervous system lymphoma.

Fukumura K, Kawazu M, Kojima S, Ueno T, Sai E, Soda M, Ueda H, Yasuda T, Yamaguchi H, Lee J, Shishido-Hara Y, Sasaki A, Shirahata M, Mishima K, Ichimura K, Mukasa A, Narita Y, Saito N, Aburatani H, Nishikawa R, Nagane M, Mano H. Genomic characterization of primary central nervous system lymphoma. Acta Neuropathol. 2016 Jun;131(6):865-75. doi: 10.1007/s00401-016-1536-2. Epub 2016 Jan 12.

IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis.

Asano Y, Kawase T, Okabe A, Tsutsumi S, Ichikawa H, Tatebe S, Kitabayashi I, Tashiro F, Namiki H, Kondo T, Semba K, Aburatani H, Taya Y, Nakagama H, Ohki R. IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis. Sci Rep. 2016 Jan 12;6:19174. doi: 10.1038/srep19174.

Prognostic significance of CpG island methylator phenotype in surgically resected small cell lung carcinoma.

Saito Y, Nagae G, Motoi N, Miyauchi E, Ninomiya H, Uehara H, Mun M, Okumura S, Ohyanagi F, Nishio M, Satoh Y, Aburatani H, Ishikawa Y. Prognostic significance of CpG island methylator phenotype in surgically resected small cell lung carcinoma. Cancer Sci. 2016 Mar;107(3):320-5. doi: 10.1111/cas.12876. Epub 2016 Feb 19.

Utility of ATRX immunohistochemistry in diagnosis of adult diffuse gliomas.

Ikemura M, Shibahara J, Mukasa A, Takayanagi S, Aihara K, Saito N, Aburatani H, Fukayama M. Utility of ATRX immunohistochemistry in diagnosis of adult diffuse gliomas. Histopathology. 2016 Aug;69(2):260-7. doi: 10.1111/his.12927. Epub 2016 Feb 23.