An Ensemble Docking Calculation of Lysozyme and HyHEL-10: Insight into the Binding Mechanism

T. Yamashita and Y. Takamatsu An Ensemble Docking Calculation of Lysozyme and HyHEL-10: Insight into the Binding Mechanism AIP Conf. Proc. 2017, 1906, 030022 https://doi.org/10.1063/1.5012301

Plasma Irradiation Effects to Intra-Abdominal Organ Compared with Adhesion Mouse Model.

Keita Soda, Hiroharu Yamashita, Kyungho Chang, Takeshi Kawamura, Takao Hamakubo and Nobuyuki Shimizu. Plasma Irradiation Effects to Intra-Abdominal Organ Compared with Adhesion Mouse Model. Plasma Medicine 2017, 7(4):347–381

Cooperative gene activation by AF4 and DOT1L drives MLL-rearranged leukemia.

Hiroshi Okuda, Boban Stanojevic, Akinori Kanai, Takeshi Kawamura, Satoshi Takahashi, Hirotaka Matsui, Akifumi Takaori-Kondo, Akihiko Yokoyama. Cooperative gene activation by AF4 and DOT1L drives MLL-rearranged leukemia. The Journal of Clinical Investegation 2017 May 1;127(5):1918-1931. doi: 10.1172/JCI91406. Epub 2017 Apr 10.

O-GlcNAc on PKCζ Inhibits the FGF4-PKCζ-MEK-ERK1/2 Pathway via Inhibition of PKCζ Phosphorylation in Mouse Embryonic Stem Cells.

Taichi Miura, Masahiko Kume, Takeshi Kawamura, Kazuo Yamamoto, Takao Hamakubo, and Shoko Nishihara. O-GlcNAc on PKCζ Inhibits the FGF4-PKCζ-MEK-ERK1/2 Pathway via Inhibition of PKCζ Phosphorylation in Mouse Embryonic Stem Cells. Stem Cell Reports. 2017 Dec 12. pii: S2213-6711(17)30514-3. doi: 10.1016/j.stemcr.2017.11.007.

Yeast genetic interaction screen of human genes associated with amyotrophic lateral sclerosis: identification of MAP2K5 kinase as a potential drug target

Jo M, Chung AY, Yachie N, Seo M, Jeon H, Nam Y, Seo Y, Kim E, Zhong Q, Vidal M, Park HC, Roth FP & Suk K Yeast genetic interaction screen of human genes associated with amyotrophic lateral sclerosis: identification of MAP2K5 kinase as a potential drug target Genome Research

Systematic analysis of Ca2+ homoeostasis in Saccharomyces cerevisiae based on chemical-genetic interaction profiles

Ghanegolmohammadia F, Yoshida M, Ohnuki S, Sukegawa Y, Okada H, Obara K, Kihara A, Suzuki K, Kojima T, Yachie N, Hirata D & Ohya Y Systematic analysis of Ca2+ homoeostasis in Saccharomyces cerevisiae based on chemical-genetic interaction profiles Molecular Biology of the Cell

MAFB prevents excess inflammation after ischemic stroke by accelerating clearance of damage signals through MSR1.

Shichita T, Ito M, Morita R, Komai K, Noguchi Y, Ooboshi H, Koshida R, Takahashi S, Kodama T, Yoshimura A. MAFB prevents excess inflammation after ischemic stroke by accelerating clearance of damage signals through MSR1. Nat Med. 2017 Jun;23(6):723-732. doi: 10.1038/nm.4312. Epub 2017 Apr 10.

Degradation of human Lipin-1 by BTRC E3 ubiquitin ligase.

Ishimoto K, Hayase A, Kumagai F, Kawai M, Okuno H, Hino N, Okada Y, Kawamura T, Tanaka T, Hamakubo T, Sakai J, Kodama T, Tachibana K, Doi T. Degradation of human Lipin-1 by BTRC E3 ubiquitin ligase. Biochem Biophys Res Commun. 2017 Jun 17;488(1):159-164. doi: 10.1016/j.bbrc.2017.04.159. Epub 2017 May 5

京速コンピューティングによる創薬への挑戦: ポスト「京」時代に向けて

山下雄史 京速コンピューティングによる創薬への挑戦: ポスト「京」時代に向けて 分子シミュレーション研究会会誌「アンサンブル」19(2) 81-87 (2017) https://doi.org/10.11436/mssj.19.81

Novel lnc RNA regulated by HIF-1 inhibits apoptotic cell death in the renal tubular epithelial cells under hypoxia.

Mimura I, Hirakawa Y, Kanki Y, Kushida N, Nakaki R, Suzuki Y, Tanaka T, Aburatani H, Nangaku M. Novel lnc RNA regulated by HIF-1 inhibits apoptotic cell death in the renal tubular epithelial cells under hypoxia. Physiol Rep. 2017 Apr;5(8). pii: e13203. doi: 10.14814/phy2.13203.

Epstein-Barr virus infection induces genome-wide de novo DNA methylation in non-neoplastic gastric epithelial cells.

Matsusaka K, Funata S, Fukuyo M, Seto Y, Aburatani H, Fukayama M, Kaneda A. Epstein-Barr virus infection induces genome-wide de novo DNA methylation in non-neoplastic gastric epithelial cells. J Pathol. 2017 Apr 18. doi: 10.1002/path.4909. [Epub ahead of print]

Negative feedback loop of bone resorption by NFATc1-dependent induction of Cadm1.

Nakamura S, Koyama T, Izawa N, Nomura S, Fujita T, Omata Y, Minami T, Matsumoto M, Nakamura M, Fujita-Jimbo E, Momoi T, Miyamoto T, Aburatani H, Tanaka S. Negative feedback loop of bone resorption by NFATc1-dependent induction of Cadm1. PLoS One. 2017 Apr 17;12(4):e0175632. doi: 10.1371/journal.pone.0175632. eCollection 2017.

Robotic crowd biology with Maholo LabDroids

Yachie N, Takahashi K, Katayama T, Sakurada T, Kanda GN, Takagi E, Hirose T, Katsura T, Moriya T, Kitano H, Tsujii J, Shiraki T, Kariyazaki H, Kamei M, Abe N, Fukuda T, Sawada Y, Hashiguchi Y, Matsukuma K, Murai S, Sasaki N, Ipposhi T, Urabe H, Kudo T, Umeno M, Ono S, Miyauchi K, Nakamura M, Kizaki T, Suyama T, Hatta T, Natsume T, Ohta T, Ozawa Y, Ihara S, Tamaki S, Antezana E, Garcia-Castro A, Perret JL, Ishiguro S, Mori H, Evans-Yamamoto D, Masuyama N, Tomita M, Katayama T, Matsumoto M, Nakayama H, Shirasawa A, Shimbo K, Yamada N, Nakayama KI, Shimizu T, Saya H, Yamashita S, Matsushima T, Asahara H, Eguchi H, Mikamori M, Mori M & Natsume T Robotic crowd biology with Maholo LabDroids Nature Biotechnology 35, 310-312

Epiregulin-blocking antibody inhibits epiregulin-dependent EGFR signaling.

Iijima M, Anai M, Kodama T, Shibasaki Y. Epiregulin-blocking antibody inhibits epiregulin-dependent EGFR signaling. Biochem Biophys Res Commun. 2017 Jul 15;489(1):83-88. doi: 10.1016/j.bbrc.2017.03.006. Epub 2017 Mar 6.

Generation and characterization of an antagonistic monoclonal antibody against an extracellular domain of mouse DP2 (CRTH2/GPR44) receptors for prostaglandin D2.

Nagata N, Iwanari H, Kumagai H, Kusano-Arai O, Ikeda Y, Aritake K, Hamakubo T, Urade Y. Generation and characterization of an antagonistic monoclonal antibody against an extracellular domain of mouse DP2 (CRTH2/GPR44) receptors for prostaglandin D2. PLoS One. 2017 Apr 10;12(4):e0175452. doi: 10.1371/journal.pone.0175452. eCollection 2017.

Differences in genetic and epigenetic alterations between von Hippel-Lindau disease-related and sporadic hemangioblastomas of the central nervous system.

Takayanagi S, Mukasa A, Tanaka S, Nomura M, Omata M, Yanagisawa S, Yamamoto S, Ichimura K, Nakatomi H, Ueki K, Aburatani H, Saito N. Differences in genetic and epigenetic alterations between von Hippel-Lindau disease-related and sporadic hemangioblastomas of the central nervous system. Neuro Oncol. 2017 Mar 30. doi: 10.1093/neuonc/nox034. [Epub ahead of print]

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