Multicenter collaborative randomized parallel group comparative study of pitavastatin and atorvastatin in Japanese hypercholesterolemic patients: collaborative study on hypercholesterolemia drug intervention and their benefits for atherosclerosis prevention (CHIBA study).

Ohta Y, Kodama T, Ihara S. Multicenter collaborative randomized parallel group comparative study of pitavastatin and atorvastatin in Japanese hypercholesterolemic patients: collaborative study on hypercholesterolemia drug intervention and their benefits for atherosclerosis prevention (CHIBA study). Phys Rev E Stat Nonlin Soft Matter Phys. 2011 Oct;84(4 Pt 1):041922. Epub 2011 Oct 19.

Epigenetic regulation of osteoclast differentiation.

Yasui T, Hirose J, Aburatani H, Tanaka S. Epigenetic regulation of osteoclast differentiation. Ann N Y Acad Sci. 2011 Dec;1240:7-13. doi: 10.1111/j.1749-6632.2011.06245.x. Review.

Whole-exome sequencing of human pancreatic cancers and characterization of genomic instability caused by MLH1 haploinsufficiency and complete deficiency.

Wang L, Tsutsumi S, Kawaguchi T, Nagasaki K, Tatsuno K, Yamamoto S, Sang F, Sonoda K, Sugawara M, Saiura A, Hirono S, Yamaue H, Miki Y, Isomura M, Totoki Y, Nagae G, Isagawa T, Ueda H, Murayama-Hosokawa S, Shibata T, Sakamoto H, Kanai Y, et al. Whole-exome sequencing of human pancreatic cancers and characterization of genomic instability caused by MLH1 haploinsufficiency and complete deficiency. Genome Res. 2012 Feb;22(2):208-19. doi: 10.1101/gr.123109.111. Epub 2011 Dec 7.

Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1.

Osawa T, Muramatsu M, Wang F, Tsuchida R, Kodama T, Minami T, Shibuya M. Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1. Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20725-9. doi: 10.1073/pnas.1108462109. Epub 2011 Dec 5.

Increased expression of histone demethylase JHDM1D under nutrient starvation suppresses tumor growth via down-regulating angiogenesis.

Osawa T, Muramatsu M, Wang F, Tsuchida R, Kodama T, Minami T, Shibuya M. Increased expression of histone demethylase JHDM1D under nutrient starvation suppresses tumor growth via down-regulating angiogenesis. Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20725-9. doi: 10.1073/pnas.1108462109. Epub 2011 Dec 5.

Oxidation of DJ-1 induced by 6-hydroxydopamine decreasing intracellular glutathione.

Miyama A, Saito Y, Yamanaka K, Hayashi K, Hamakubo T, Noguchi N. Oxidation of DJ-1 induced by 6-hydroxydopamine decreasing intracellular glutathione. PLoS One. 2011;6(11):e27883. doi: 10.1371/journal.pone.0027883. Epub 2011 Nov 21.

Potential responders to FOLFOX therapy for colorectal cancer by Random Forests analysis.

Tsuji S, Midorikawa Y, Takahashi T, Yagi K, Takayama T, Yoshida K, Sugiyama Y, Aburatani H. Potential responders to FOLFOX therapy for colorectal cancer by Random Forests analysis. Br J Cancer. 2012 Jan 3;106(1):126-32. doi: 10.1038/bjc.2011.505. Epub 2011 Nov 17.

Basophil-derived mouse mast cell protease 11 induces microvascular leakage and tissue edema in a mast cell-independent manner.

Yamagishi H, Mochizuki Y, Hamakubo T, Obata K, Ugajin T, Sato S, Kawano Y, Minegishi Y, Karasuyama H. Basophil-derived mouse mast cell protease 11 induces microvascular leakage and tissue edema in a mast cell-independent manner. Biochem Biophys Res Commun. 2011 Dec 2;415(4):709-13. doi: 10.1016/j.bbrc.2011.10.150. Epub 2011 Nov 6.

Activation of Bmp2-Smad1 signal and its regulation by coordinated alteration of H3K27 trimethylation in Ras-induced senescence.

Kaneda A, Fujita T, Anai M, Yamamoto S, Nagae G, Morikawa M, Tsuji S, Oshima M, Miyazono K, Aburatani H. Activation of Bmp2-Smad1 signal and its regulation by coordinated alteration of H3K27 trimethylation in Ras-induced senescence. PLoS Genet. 2011 Nov;7(11):e1002359. doi: 10.1371/journal.pgen.1002359. Epub 2011 Nov 3.

Heterogeneity in immunohistochemical, genomic, and biological properties of human lymphatic endothelial cells between initial and collecting lymph vessels.

Fujimura T, Takahashi S, Urano T, Tanaka T, Zhang W, Azuma K, Takayama K, Obinata D, Murata T, Horie-Inoue K, Kodama T, Ouchi Y, Homma Y, Inoue S. Heterogeneity in immunohistochemical, genomic, and biological properties of human lymphatic endothelial cells between initial and collecting lymph vessels. Cancer Sci. 2012 Feb;103(2):176-80. doi: 10.1111/j.1349-7006.2011.02143.x. Epub 2011 Nov 27.

Clinical significance of steroid and xenobiotic receptor and its targeted gene CYP3A4 in human prostate cancer.

Fujimura T, Takahashi S, Urano T, Tanaka T, Zhang W, Azuma K, Takayama K, Obinata D, Murata T, Horie-Inoue K, Kodama T, Ouchi Y, Homma Y, Inoue S. Clinical significance of steroid and xenobiotic receptor and its targeted gene CYP3A4 in human prostate cancer. Cancer Sci. 2012 Feb;103(2):176-80. doi: 10.1111/j.1349-7006.2011.02143.x. Epub 2011 Nov 27.

Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals.

Waki H, Nakamura M, Yamauchi T, Wakabayashi K, Yu J, Hirose-Yotsuya L, Take K, Sun W, Iwabu M, Okada-Iwabu M, Fujita T, Aoyama T, Tsutsumi S, Ueki K, Kodama T, Sakai J, Aburatani H, Kadowaki T. Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals. PLoS Genet. 2011 Oct;7(10):e1002311. doi: 10.1371/journal.pgen.1002311. Epub 2011 Oct 20.

Global mapping of cell type-specific open chromatin by FAIRE-seq reveals the regulatory role of the NFI family in adipocyte differentiation.

Waki H, Nakamura M, Yamauchi T, Wakabayashi K, Yu J, Hirose-Yotsuya L, Take K, Sun W, Iwabu M, Okada-Iwabu M, Fujita T, Aoyama T, Tsutsumi S, Ueki K, Kodama T, Sakai J, Aburatani H, Kadowaki T. Global mapping of cell type-specific open chromatin by FAIRE-seq reveals the regulatory role of the NFI family in adipocyte differentiation. PLoS Genet. 2011 Oct;7(10):e1002311. doi: 10.1371/journal.pgen.1002311. Epub 2011 Oct 20.

MUC13 mucin augments pancreatic tumorigenesis.

Chauhan SC, Ebeling MC, Maher DM, Koch MD, Watanabe A, Aburatani H, Lio Y, Jaggi M. MUC13 mucin augments pancreatic tumorigenesis. Mol Cancer Ther. 2012 Jan;11(1):24-33. doi: 10.1158/1535-7163.MCT-11-0598. Epub 2011 Oct 25.

Characterization and microarray analysis of genes in human lymphatic endothelial cells from patients with breast cancer.

Negishi-Koga T, Shinohara M, Komatsu N, Bito H, Kodama T, Friedel RH, Takayanagi H. Characterization and microarray analysis of genes in human lymphatic endothelial cells from patients with breast cancer. Nat Med. 2011 Oct 23;17(11):1473-80. doi: 10.1038/nm.2489.

DNA methylation profiling of embryonic stem cell differentiation into the three germ layers.

Isagawa T, Nagae G, Shiraki N, Fujita T, Sato N, Ishikawa S, Kume S, Aburatani H. DNA methylation profiling of embryonic stem cell differentiation into the three germ layers. PLoS One. 2011;6(10):e26052. doi: 10.1371/journal.pone.0026052. Epub 2011 Oct 7.