Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity.

Okawa H, Motohashi H, Kobayashi A, Aburatani H, Kensler TW, Yamamoto M.Biochem. Biophys. Res. Commun. 2006 Jan 06;339(1):79-88. doi: 10.1016/j.bbrc.2005.10.185