Yeast genetic interaction screen of human genes associated with amyotrophic lateral sclerosis: identification of MAP2K5 kinase as a potential drug target

Jo M, Chung AY, Yachie N, Seo M, Jeon H, Nam Y, Seo Y, Kim E, Zhong Q, Vidal M, Park HC, Roth FP & Suk K Yeast genetic interaction screen of human genes associated with amyotrophic lateral sclerosis: identification of MAP2K5 kinase as a potential drug target Genome Research

Systematic analysis of Ca2+ homoeostasis in Saccharomyces cerevisiae based on chemical-genetic interaction profiles

Ghanegolmohammadia F, Yoshida M, Ohnuki S, Sukegawa Y, Okada H, Obara K, Kihara A, Suzuki K, Kojima T, Yachie N, Hirata D & Ohya Y Systematic analysis of Ca2+ homoeostasis in Saccharomyces cerevisiae based on chemical-genetic interaction profiles Molecular Biology of the Cell

MAFB prevents excess inflammation after ischemic stroke by accelerating clearance of damage signals through MSR1.

Shichita T, Ito M, Morita R, Komai K, Noguchi Y, Ooboshi H, Koshida R, Takahashi S, Kodama T, Yoshimura A. MAFB prevents excess inflammation after ischemic stroke by accelerating clearance of damage signals through MSR1. Nat Med. 2017 Jun;23(6):723-732. doi: 10.1038/nm.4312. Epub 2017 Apr 10.

Degradation of human Lipin-1 by BTRC E3 ubiquitin ligase.

Ishimoto K, Hayase A, Kumagai F, Kawai M, Okuno H, Hino N, Okada Y, Kawamura T, Tanaka T, Hamakubo T, Sakai J, Kodama T, Tachibana K, Doi T. Degradation of human Lipin-1 by BTRC E3 ubiquitin ligase. Biochem Biophys Res Commun. 2017 Jun 17;488(1):159-164. doi: 10.1016/j.bbrc.2017.04.159. Epub 2017 May 5

Novel lnc RNA regulated by HIF-1 inhibits apoptotic cell death in the renal tubular epithelial cells under hypoxia.

Mimura I, Hirakawa Y, Kanki Y, Kushida N, Nakaki R, Suzuki Y, Tanaka T, Aburatani H, Nangaku M. Novel lnc RNA regulated by HIF-1 inhibits apoptotic cell death in the renal tubular epithelial cells under hypoxia. Physiol Rep. 2017 Apr;5(8). pii: e13203. doi: 10.14814/phy2.13203.

Epstein-Barr virus infection induces genome-wide de novo DNA methylation in non-neoplastic gastric epithelial cells.

Matsusaka K, Funata S, Fukuyo M, Seto Y, Aburatani H, Fukayama M, Kaneda A. Epstein-Barr virus infection induces genome-wide de novo DNA methylation in non-neoplastic gastric epithelial cells. J Pathol. 2017 Apr 18. doi: 10.1002/path.4909. [Epub ahead of print]

Negative feedback loop of bone resorption by NFATc1-dependent induction of Cadm1.

Nakamura S, Koyama T, Izawa N, Nomura S, Fujita T, Omata Y, Minami T, Matsumoto M, Nakamura M, Fujita-Jimbo E, Momoi T, Miyamoto T, Aburatani H, Tanaka S. Negative feedback loop of bone resorption by NFATc1-dependent induction of Cadm1. PLoS One. 2017 Apr 17;12(4):e0175632. doi: 10.1371/journal.pone.0175632. eCollection 2017.

Robotic crowd biology with Maholo LabDroids

Yachie N, Takahashi K, Katayama T, Sakurada T, Kanda GN, Takagi E, Hirose T, Katsura T, Moriya T, Kitano H, Tsujii J, Shiraki T, Kariyazaki H, Kamei M, Abe N, Fukuda T, Sawada Y, Hashiguchi Y, Matsukuma K, Murai S, Sasaki N, Ipposhi T, Urabe H, Kudo T, Umeno M, Ono S, Miyauchi K, Nakamura M, Kizaki T, Suyama T, Hatta T, Natsume T, Ohta T, Ozawa Y, Ihara S, Tamaki S, Antezana E, Garcia-Castro A, Perret JL, Ishiguro S, Mori H, Evans-Yamamoto D, Masuyama N, Tomita M, Katayama T, Matsumoto M, Nakayama H, Shirasawa A, Shimbo K, Yamada N, Nakayama KI, Shimizu T, Saya H, Yamashita S, Matsushima T, Asahara H, Eguchi H, Mikamori M, Mori M & Natsume T Robotic crowd biology with Maholo LabDroids Nature Biotechnology 35, 310-312

Epiregulin-blocking antibody inhibits epiregulin-dependent EGFR signaling.

Iijima M, Anai M, Kodama T, Shibasaki Y. Epiregulin-blocking antibody inhibits epiregulin-dependent EGFR signaling. Biochem Biophys Res Commun. 2017 Jul 15;489(1):83-88. doi: 10.1016/j.bbrc.2017.03.006. Epub 2017 Mar 6.

Generation and characterization of an antagonistic monoclonal antibody against an extracellular domain of mouse DP2 (CRTH2/GPR44) receptors for prostaglandin D2.

Nagata N, Iwanari H, Kumagai H, Kusano-Arai O, Ikeda Y, Aritake K, Hamakubo T, Urade Y. Generation and characterization of an antagonistic monoclonal antibody against an extracellular domain of mouse DP2 (CRTH2/GPR44) receptors for prostaglandin D2. PLoS One. 2017 Apr 10;12(4):e0175452. doi: 10.1371/journal.pone.0175452. eCollection 2017.

Differences in genetic and epigenetic alterations between von Hippel-Lindau disease-related and sporadic hemangioblastomas of the central nervous system.

Takayanagi S, Mukasa A, Tanaka S, Nomura M, Omata M, Yanagisawa S, Yamamoto S, Ichimura K, Nakatomi H, Ueki K, Aburatani H, Saito N. Differences in genetic and epigenetic alterations between von Hippel-Lindau disease-related and sporadic hemangioblastomas of the central nervous system. Neuro Oncol. 2017 Mar 30. doi: 10.1093/neuonc/nox034. [Epub ahead of print]

Visualization of ligand-induced Gi-protein activation in chemotaxing cells.

Masuda K, Kitakami JI, Kozasa T, Kodama T, Ihara S, Hamakubo T. Visualization of ligand-induced Gi-protein activation in chemotaxing cells. FASEB J. 2017 Mar;31(3):910-919. doi: 10.1096/fj.201601102R

Dynamically and epigenetically coordinated GATA/ETS/SOX transcription factor expression is indispensable for endothelial cell differentiation.

Kanki Y, Nakaki R, Shimamura T, Matsunaga T, Yamamizu K, Katayama S, Suehiro JI, Osawa T, Aburatani H, Kodama T, Wada Y, Yamashita JK, Minami T. Dynamically and epigenetically coordinated GATA/ETS/SOX transcription factor expression is indispensable for endothelial cell differentiation. Nucleic Acids Res. 2017 May 5;45(8):4344-4358. doi: 10.1093/nar/gkx159.

Genetic and epigenetic stability of oligodendrogliomas at recurrence.

Aihara K, Mukasa A, Nagae G, Nomura M, Yamamoto S, Ueda H, Tatsuno K, Shibahara J, Takahashi M, Momose T, Tanaka S, Takayanagi S, Yanagisawa S, Nejo T, Takahashi S, Omata M, Otani R, Saito K, Narita Y, Nagane M, Nishikawa R, Ueki K, et al. Genetic and epigenetic stability of oligodendrogliomas at recurrence. Acta Neuropathol Commun. 2017 Mar 7;5(1):18. doi: 10.1186/s40478-017-0422-z.

Extracellular Acidic pH Activates the Sterol Regulatory Element-Binding Protein 2 to Promote Tumor Progression.

Kondo A, Yamamoto S, Nakaki R, Shimamura T, Hamakubo T, Sakai J, Kodama T, Yoshida T, Aburatani H, Osawa T. Extracellular Acidic pH Activates the Sterol Regulatory Element-Binding Protein 2 to Promote Tumor Progression. Cell Rep. 2017 Feb 28;18(9):2228-2242. doi: 10.1016/j.celrep.2017.02.006.

Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP.

Asano L, Watanabe M, Ryoden Y, Usuda K, Yamaguchi T, Khambu B, Takashima M, Sato SI, Sakai J, Nagasawa K, Uesugi M. Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP. Cell Chem Biol. 2017 Feb 16;24(2):207-217. doi: 10.1016/j.chembiol.2016.12.017. Epub 2017 Jan 26.