Development of Drug Discovery Screening System by Molecular Interaction Kinetics Mass Spectrometry.

Obi N, Fukuda T, Nakayama N, Ervin J, Bando Y, Nishimura T, Nagatoishi S, Tsumoto K, Kawamura T. Development of Drug Discovery Screening System by Molecular Interaction Kinetics Mass Spectrometry. Rapid Commun Mass Spectrom. 2018 Feb 14. doi: 10.1002/rcm.8083. [Epub ahead of print] PMID: 29441684

Hierarchical roles of mitochondrial Papi and Zucchini in Bombyx germline piRNA biogenesis.

Nishida KM, Sakakibara K, Iwasaki YW, Yamada H, Murakami R, Murota Y, Kawamura T, Kodama T, Siomi H, Siomi MC. Hierarchical roles of mitochondrial Papi and Zucchini in Bombyx germline piRNA biogenesis. Nature. 2018 Mar 8;555(7695):260-264. doi: 10.1038/nature25788. Epub 2018 Feb 28. PMID: 29489748

Multiplicity in Long Noncoding RNA Biomedical Sciences

R. Kurokawa, R. Komiya, T. Oyoshi, Y. Matsuno, H. Tani, M. Katahira, K. Hitachi, Y. Iwashita, T. Yamashita, K. Kondo, R. Yoneda, Y. Yamaoki, N. Ueda, T. Mashima, N. Kobayashi, T. Nagata, A. Kiyoishi, M. Miyake, F. Kano, M. Murata1, N. Hamad, K. Sasaki, N. Shoji Multiplicity in Long Noncoding RNA Biomedical Sciences Biomedical Sciences 4, 18-23 (2018)

Tyrosine Sulfation Restricts the Conformational Ensemble of a Flexible Peptide, Strengthening the Binding Affinity for an Antibody

K. Miyanabe, T. Yamashita, Y. Abe, H. Akiba, Y. Takamatsu, M. Nakakido, T. Hamakubo, T. Ueda, J. Caaveiro, K. Tsumoto,

Tyrosine Sulfation Restricts the Conformational Ensemble of a Flexible Peptide, Strengthening the Binding Affinity for an Antibody Biochemistry, 57 (28), pp 4177–4185 (2018) DOI: 10.1021/acs.biochem.8b00592

Discovery of peroxisome proliferator–activated receptor α (PPARα) activators with a ligandscreening system using a human PPARα-expressing cell line.

Keisuke Tachibana, Tomohiro Yuzuriha, Ryotaro Tabata, Syohei Fukuda, Takashi Maegawa, Rika Takahashi, Keiichi Tanimoto, Hirofumi Tsujino, Kazuto Nunomura, Bangzhong Lin, Yoshiharu Matsuura, Toshiya Tanaka, Takao Hamakubo, Juro Sakai, Tatsuhiko Kodama, Tadayuki Kobayashi, Kenji Ishimoto, Hiroyuki Miyachi, and Takefumi Doi. Discovery of peroxisome proliferator–activated receptor α (PPARα) activators with a ligandscreening system using a human PPARα-expressing cell line. J. Biol. Chem., In press.

What consequence is anticipated by the emergence of novel SPPARMa agent developed so as to achieve an improved safety/efficacy balance?

Motonobu Anai, Toshiya Tanaka, Tatsuhiko Kodama. What consequence is anticipated by the emergence of novel SPPARMa agent developed so as to achieve an improved safety/efficacy balance? Jpn Pharmacol. Ther., 46: 471-480 (2018).

Overexpression of p54nrb/NONO induces differential EPHA6 splicing and contributes to castration-resistant prostate cancer growth.

Yamamoto R, Osawa T, Sasaki Y, Yamamoto S, Anai M, Izumi K, Matsumura Y, Sakai J, Aburatani H, Mizokami A, Kodama T, Tanaka T. Overexpression of p54nrb/NONO induces differential EPHA6 splicing and contributes to castration-resistant prostate cancer growth. Oncotarget. 2018 Jan 8;9(12):10510-10524. doi: 10.18632/oncotarget.24063.

The Influence of Pemafibrate (Parmodia Tablet) on Liver and Renal Function

Toshiya Tanaka, Motonobu Anai, and Tatsuhiko Kodama The Influence of Pemafibrate (Parmodia Tablet) on Liver and Renal Function J Pharmacol Ther. 2017 Nov 20; 45(11):1775-1785.

Aberrant DNA methylation of pregnane X receptor underlies metabolic gene alterations in the diabetic kidney.

Watanabe A, Marumo T, Kawarazaki W, Nishimoto M, Ayuzawa N, Ueda K, Hirohama D, Tanaka T, Yagi S, Ota S, Nagae G, Aburatani H, Kumagai H, Fujita T. Aberrant DNA methylation of pregnane X receptor underlies metabolic gene alterations in the diabetic kidney. Am J Physiol Renal Physiol. 2018 Apr 1;314(4):F551-F560. doi: 10.1152/ajprenal.00390.2017.

Toward rational antibody design: recent advancements in molecular dynamics simulations

T. Yamashita Toward rational antibody design: recent advancements in molecular dynamics simulations Int. Immunol., 30, 133–140 (2018) doi: 10.1093/intimm/dxx077

Identification of MYLK3 mutations in familial dilated cardiomyopathy

Takashige Tobita, Seitaro Nomura, Hiroyuki Morita, Toshiyuki Ko, Takanori Fujita, Haruhiro Toko, Kenta Uto, Nobuhisa Hagiwara, Hiroyuki Aburatani, Issei Komuro Identification of MYLK3 mutations in familial dilated cardiomyopathy Scientific Reports 7, Article number: 17495 (2017)
doi:10.1038/s41598-017-17769-1

An Ensemble Docking Calculation of Lysozyme and HyHEL-10: Insight into the Binding Mechanism

T. Yamashita and Y. Takamatsu An Ensemble Docking Calculation of Lysozyme and HyHEL-10: Insight into the Binding Mechanism AIP Conf. Proc. 2017, 1906, 030022 https://doi.org/10.1063/1.5012301

Plasma Irradiation Effects to Intra-Abdominal Organ Compared with Adhesion Mouse Model.

Keita Soda, Hiroharu Yamashita, Kyungho Chang, Takeshi Kawamura, Takao Hamakubo and Nobuyuki Shimizu. Plasma Irradiation Effects to Intra-Abdominal Organ Compared with Adhesion Mouse Model. Plasma Medicine 2017, 7(4):347–381

Cooperative gene activation by AF4 and DOT1L drives MLL-rearranged leukemia.

Hiroshi Okuda, Boban Stanojevic, Akinori Kanai, Takeshi Kawamura, Satoshi Takahashi, Hirotaka Matsui, Akifumi Takaori-Kondo, Akihiko Yokoyama. Cooperative gene activation by AF4 and DOT1L drives MLL-rearranged leukemia. The Journal of Clinical Investegation 2017 May 1;127(5):1918-1931. doi: 10.1172/JCI91406. Epub 2017 Apr 10.

O-GlcNAc on PKCζ Inhibits the FGF4-PKCζ-MEK-ERK1/2 Pathway via Inhibition of PKCζ Phosphorylation in Mouse Embryonic Stem Cells.

Taichi Miura, Masahiko Kume, Takeshi Kawamura, Kazuo Yamamoto, Takao Hamakubo, and Shoko Nishihara. O-GlcNAc on PKCζ Inhibits the FGF4-PKCζ-MEK-ERK1/2 Pathway via Inhibition of PKCζ Phosphorylation in Mouse Embryonic Stem Cells. Stem Cell Reports. 2017 Dec 12. pii: S2213-6711(17)30514-3. doi: 10.1016/j.stemcr.2017.11.007.

Yeast genetic interaction screen of human genes associated with amyotrophic lateral sclerosis: identification of MAP2K5 kinase as a potential drug target

Jo M, Chung AY, Yachie N, Seo M, Jeon H, Nam Y, Seo Y, Kim E, Zhong Q, Vidal M, Park HC, Roth FP & Suk K Yeast genetic interaction screen of human genes associated with amyotrophic lateral sclerosis: identification of MAP2K5 kinase as a potential drug target Genome Research