Overexpression of p54nrb/NONO induces differential EPHA6 splicing and contributes to castration-resistant prostate cancer growth.

Yamamoto R, Osawa T, Sasaki Y, Yamamoto S, Anai M, Izumi K, Matsumura Y, Sakai J, Aburatani H, Mizokami A, Kodama T, Tanaka T. Overexpression of p54nrb/NONO induces differential EPHA6 splicing and contributes to castration-resistant prostate cancer growth. Oncotarget. 2018 Jan 8;9(12):10510-10524. doi: 10.18632/oncotarget.24063.

The Influence of Pemafibrate (Parmodia Tablet) on Liver and Renal Function

Toshiya Tanaka, Motonobu Anai, and Tatsuhiko Kodama The Influence of Pemafibrate (Parmodia Tablet) on Liver and Renal Function J Pharmacol Ther. 2017 Nov 20; 45(11):1775-1785.

Aberrant DNA methylation of pregnane X receptor underlies metabolic gene alterations in the diabetic kidney.

Watanabe A, Marumo T, Kawarazaki W, Nishimoto M, Ayuzawa N, Ueda K, Hirohama D, Tanaka T, Yagi S, Ota S, Nagae G, Aburatani H, Kumagai H, Fujita T. Aberrant DNA methylation of pregnane X receptor underlies metabolic gene alterations in the diabetic kidney. Am J Physiol Renal Physiol. 2018 Apr 1;314(4):F551-F560. doi: 10.1152/ajprenal.00390.2017.

Toward rational antibody design: recent advancements in molecular dynamics simulations

T. Yamashita Toward rational antibody design: recent advancements in molecular dynamics simulations Int. Immunol., 30, 133–140 (2018) doi: 10.1093/intimm/dxx077

Identification of MYLK3 mutations in familial dilated cardiomyopathy

Takashige Tobita, Seitaro Nomura, Hiroyuki Morita, Toshiyuki Ko, Takanori Fujita, Haruhiro Toko, Kenta Uto, Nobuhisa Hagiwara, Hiroyuki Aburatani, Issei Komuro Identification of MYLK3 mutations in familial dilated cardiomyopathy Scientific Reports 7, Article number: 17495 (2017)
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An Ensemble Docking Calculation of Lysozyme and HyHEL-10: Insight into the Binding Mechanism

T. Yamashita and Y. Takamatsu An Ensemble Docking Calculation of Lysozyme and HyHEL-10: Insight into the Binding Mechanism AIP Conf. Proc. 2017, 1906, 030022 https://doi.org/10.1063/1.5012301

Yeast genetic interaction screen of human genes associated with amyotrophic lateral sclerosis: identification of MAP2K5 kinase as a potential drug target

Jo M, Chung AY, Yachie N, Seo M, Jeon H, Nam Y, Seo Y, Kim E, Zhong Q, Vidal M, Park HC, Roth FP & Suk K Yeast genetic interaction screen of human genes associated with amyotrophic lateral sclerosis: identification of MAP2K5 kinase as a potential drug target Genome Research

Systematic analysis of Ca2+ homoeostasis in Saccharomyces cerevisiae based on chemical-genetic interaction profiles

Ghanegolmohammadia F, Yoshida M, Ohnuki S, Sukegawa Y, Okada H, Obara K, Kihara A, Suzuki K, Kojima T, Yachie N, Hirata D & Ohya Y Systematic analysis of Ca2+ homoeostasis in Saccharomyces cerevisiae based on chemical-genetic interaction profiles Molecular Biology of the Cell

MAFB prevents excess inflammation after ischemic stroke by accelerating clearance of damage signals through MSR1.

Shichita T, Ito M, Morita R, Komai K, Noguchi Y, Ooboshi H, Koshida R, Takahashi S, Kodama T, Yoshimura A. MAFB prevents excess inflammation after ischemic stroke by accelerating clearance of damage signals through MSR1. Nat Med. 2017 Jun;23(6):723-732. doi: 10.1038/nm.4312. Epub 2017 Apr 10.

Degradation of human Lipin-1 by BTRC E3 ubiquitin ligase.

Ishimoto K, Hayase A, Kumagai F, Kawai M, Okuno H, Hino N, Okada Y, Kawamura T, Tanaka T, Hamakubo T, Sakai J, Kodama T, Tachibana K, Doi T. Degradation of human Lipin-1 by BTRC E3 ubiquitin ligase. Biochem Biophys Res Commun. 2017 Jun 17;488(1):159-164. doi: 10.1016/j.bbrc.2017.04.159. Epub 2017 May 5

京速コンピューティングによる創薬への挑戦: ポスト「京」時代に向けて

山下雄史 京速コンピューティングによる創薬への挑戦: ポスト「京」時代に向けて 分子シミュレーション研究会会誌「アンサンブル」19(2) 81-87 (2017) https://doi.org/10.11436/mssj.19.81

Novel lnc RNA regulated by HIF-1 inhibits apoptotic cell death in the renal tubular epithelial cells under hypoxia.

Mimura I, Hirakawa Y, Kanki Y, Kushida N, Nakaki R, Suzuki Y, Tanaka T, Aburatani H, Nangaku M. Novel lnc RNA regulated by HIF-1 inhibits apoptotic cell death in the renal tubular epithelial cells under hypoxia. Physiol Rep. 2017 Apr;5(8). pii: e13203. doi: 10.14814/phy2.13203.

Epstein-Barr virus infection induces genome-wide de novo DNA methylation in non-neoplastic gastric epithelial cells.

Matsusaka K, Funata S, Fukuyo M, Seto Y, Aburatani H, Fukayama M, Kaneda A. Epstein-Barr virus infection induces genome-wide de novo DNA methylation in non-neoplastic gastric epithelial cells. J Pathol. 2017 Apr 18. doi: 10.1002/path.4909. [Epub ahead of print]

Negative feedback loop of bone resorption by NFATc1-dependent induction of Cadm1.

Nakamura S, Koyama T, Izawa N, Nomura S, Fujita T, Omata Y, Minami T, Matsumoto M, Nakamura M, Fujita-Jimbo E, Momoi T, Miyamoto T, Aburatani H, Tanaka S. Negative feedback loop of bone resorption by NFATc1-dependent induction of Cadm1. PLoS One. 2017 Apr 17;12(4):e0175632. doi: 10.1371/journal.pone.0175632. eCollection 2017.

Robotic crowd biology with Maholo LabDroids

Yachie N, Takahashi K, Katayama T, Sakurada T, Kanda GN, Takagi E, Hirose T, Katsura T, Moriya T, Kitano H, Tsujii J, Shiraki T, Kariyazaki H, Kamei M, Abe N, Fukuda T, Sawada Y, Hashiguchi Y, Matsukuma K, Murai S, Sasaki N, Ipposhi T, Urabe H, Kudo T, Umeno M, Ono S, Miyauchi K, Nakamura M, Kizaki T, Suyama T, Hatta T, Natsume T, Ohta T, Ozawa Y, Ihara S, Tamaki S, Antezana E, Garcia-Castro A, Perret JL, Ishiguro S, Mori H, Evans-Yamamoto D, Masuyama N, Tomita M, Katayama T, Matsumoto M, Nakayama H, Shirasawa A, Shimbo K, Yamada N, Nakayama KI, Shimizu T, Saya H, Yamashita S, Matsushima T, Asahara H, Eguchi H, Mikamori M, Mori M & Natsume T Robotic crowd biology with Maholo LabDroids Nature Biotechnology 35, 310-312

Epiregulin-blocking antibody inhibits epiregulin-dependent EGFR signaling.

Iijima M, Anai M, Kodama T, Shibasaki Y. Epiregulin-blocking antibody inhibits epiregulin-dependent EGFR signaling. Biochem Biophys Res Commun. 2017 Jul 15;489(1):83-88. doi: 10.1016/j.bbrc.2017.03.006. Epub 2017 Mar 6.