Single chain variable fragment against nicastrin inhibits the gamma-secretase activity.

Hayashi I, Takatori S, Urano Y, Iwanari H, Isoo N, Osawa S, Fukuda MA, Kodama T, Hamakubo T, Li T, Wong PC, Tomita T, Iwatsubo T.J. Biol. Chem. 2009 Oct 09;284(41):27838-47. doi: 10.1074/jbc.M109.055061