Staff

ゲノムサイエンス

教授
油谷 浩幸
Professor Hiroyuki ABURATANI
専門分野： ゲノムサイエンス
研究内容： ゲノム科学、機能ゲノミクス、癌のシステム生物学
■ 先端科学技術研究センター　ゲノムサイエンス分野

生命情報を統合解析し、データを可視化する新規生命情報システムの樹立を目指す

多重な生命情報をハイスループットに収集し、生命現象および癌を中心とする疾患のメカニズムを統合的に理解することを目指している。

転写ネットワークの解明 （図1）

従来の転写制御研究とゲノム科学を統合する「転写レギュローム」プロジェクトをスタートしました。 いまやヒトの全ゲノム配列を数枚のアレイ上に合成することが可能となり、 「遺伝暗号」ともいうべきゲノム配列中に含まれる機能情報を解明することが可能になりつつある。 遺伝子発現情報のみならず、クロマチン修飾やゲノムメチル化などのエピジェネティックス、 転写因子複合体とゲノムの相互作用を網羅的に解析することを行っている。 LSBM内の井原研究室および先端研内の情報系研究室との連携の下に研究を推進している。

遺伝子発現多様性解析（Regulatory Genomics）

染色体およびRNAのレベルからゲノムの多様性を解明するプロジェクト （戦略的創造研究推進事業「染色体およびRNAの機能変化からの疾患の系統的解析」）を新たにスタートし、 疾患感受性や薬剤感受性の遺伝的素因を明らかにすることを目指している。 これまでにゲノム配列中のコピー数を定量するアルゴリズムGenome Imbalance Mapを開発し、 ゲノムコピー数の多様性（CNV）の全ゲノムマップを作成した（Nature 2006）（図2）。 さらにアレル間の遺伝子発現多様性を検出する技術開発を進めることにより、 インプリンティング現象やアレル特異的な転写制御機構の解明を行い、 最終的に一塩基多型（SNP）などの多型情報との統合を進める予定である。

トランスレーショナル研究（ゲノム情報と医療）

個別化医療を実現するためには、症例をゲノム、エピゲノム情報にもとづいて層別化し、最適な治療法を選択する必要がある。 癌をはじめとする疾患特異的な標的分子を特定し、LSBM内の他の研究室と協力しながら特異的抗体を作成することにより、 新規腫瘍マーカー、分子標的治療の開発を目指している。（図3）


図1　p53結合とヒストン修飾


図2　ヒトゲノムコピー数多型マップ


図3　ヒト肝細胞癌で高発現するGlypican3

原著論文

業績
研究論文数 185編（和文誌15編、欧文誌170編）
著書（レビュー）数 56編（和文誌52編、欧文誌4編）

    欧文論文

    ---2007

  1. Takayama K, Kaneshiro K, Tsutsumi S, Horie-Inoue K, Ikeda K, Urano T, Ijichi N, Ouchi Y, Shirahige K, Aburatani H, Inoue S. Identification of novel androgen response genes in prostate cancer cells by coupling chromatin immunoprecipitation and genomic microarray analysis. Oncogene. 2007 Feb 5; [Epub ahead of print]
  2. Yoshizumi S, Suzuki S, Hirai M, Hinokio Y, Yamada T, Yamada T, Tsunoda U, Aburatani H, Yamaguchi K, Miyagi T, Oka Y. Increased hepatic expression of ganglioside-specific sialidase, NEU3, improves insulin sensitivity and glucose tolerance in mice. Metabolism. 56(3):420-9. 2007
  3. Terami H, Hidaka K, Shirai M, Narumiya H, Kuroyanagi T, Arai Y, Aburatani H, Morisaki T. Efficient capture of cardiogenesis-associated genes expressed in ES cells. Biochem Biophys Res Commun. 355(1):47-53. 2007 [Epub 2007 Jan 30].
  4. Murata-Kamiya N, Kurashima Y, Teishikata Y, Yamahashi Y, Saito Y, Higashi H, Aburatani H, Akiyama T, Peek RM Jr, Azuma T, Hatakeyama M. Helicobacter pylori CagA interacts with E-cadherin and deregulates the beta-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells. Oncogene. 2007 Jan 22; [Epub ahead of print]
  5. Tonami K, Kurihara Y, Aburatani H, Uchijima Y, Asano T, Kurihara H. Calpain 6 Is Involved in Microtubule Stabilization and Cytoskeletal Organization. Mol Cell Biol. 27(7):2548-61. 2007 [Epub 2007 Jan 8]
  6. Terauchi Y, Takamoto I, Kubota N, Matsui J, Suzuki R, Komeda K, Hara A, Toyoda Y, Miwa I, Aizawa S, Tsutsumi S, Tsubamoto Y, Hashimoto S, Eto K, Nakamura A, Noda M, Tobe K, Aburatani H, Nagai R, Kadowaki T. Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance. J Clin Invest. 117(1):246-257. 2007

    7. ---2006

  7. Hasegawa H, Takano H, Kohro T, Ueda K, Niitsuma Y, Aburatani H, Komuro I. Amelioration of hypertensive heart failure by amlodipine may occur via antioxidative effects. Hypertens Res. 29(9):719-29. 2006
  8. Omori-Inoue M, Fukata H, Komiyama M, Todaka E, Osada H, Aburatani H, Mori C. The contamination levels of organochlorines and the pattern of gene expressions in human umbilical cords from intra-pairs of twins at delivery. Reprod Toxicol. 2006 Nov 12; [Epub ahead of print]
  9. Hiratsuka S, Watanabe A, Aburatani H, Maru Y. Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis. Nat Cell Biol. 8(12):1369-75, 2006
  10. Redon R, Ishikawa S, Fitch KR, Feuk L, Perry GH, Andrews TD, Fiegler H, Shapero MH, Carson AR, Chen W, Cho EK, Dallaire S, Freeman JL, Gonzalez JR, Gratacos M, Huang J, Kalaitzopoulos D, Komura D, Macdonald JR, Marshall CR, Mei R, Montgomery L, Nishimura K, Okamura K, Shen F, Somerville MJ, Tchinda J, Valsesia A, Woodwark C, Yang F, Zhang J, Zerjal T, Zhang J, Armengol L, Conrad DF, Estivill X, Tyler-Smith C, Carter NP, Aburatani H, Lee C, Jones KW, Scherer SW, Hurles ME. Global variation in copy number in the human genome. Nature. 444(7118):444-454. 2006
  11. Komura D, Shen F, Ishikawa S, Fitch KR, Chen W, Zhang J, Liu G, Ihara S, Nakamura H, Hurles ME, Lee C, Scherer SW, Jones KW, Shapero MH, Huang J, Aburatani H. Genome-wide detection of human copy number variations using high-density DNA oligonucleotide arrays. Genome Res. 16(12):1575-1584, 2006
  12. Khaja R, Zhang J, Macdonald JR, He Y, Joseph-George AM, Wei J, Rafiq MA, Qian C, Shago M, Pantano L, Aburatani H, Jones K, Redon R, Hurles M, Armengol L, Estivill X, Mural RJ, Lee C, Scherer SW, Feuk L. Genome assembly comparison identifies structural variants in the human genome. Nat Genet. 38(12):1413-8, 2006
  13. Sakamoto M, Minamino T, Toko H, Kayama Y, Zou Y, Sano M, Takaki E, Aoyagi T, Tojo K, Tajima N, Nakai A, Aburatani H, Komuro I. Upregulation of Heat Shock Transcription Factor 1 Plays a Critical Role in Adaptive Cardiac Hypertrophy. Circ Res. 99(12):1411-8. 2006
  14. Horiuchi K, Umetani M, Minami T, Okayama H, Takada S, Yamamoto M, Aburatani H, Reid PC, Housman DE, Hamakubo T, Kodama T. Wilms' tumor 1-associating protein regulates G2/M transition through stabilization of cyclin A2 mRNA. Proc Natl Acad Sci U S A. 103(46):17278-83, 2006
  15. Kaneshiro K, Tsutsumi S, Tsuji S, Shirahige K, Aburatani H. An Integrated Map of p53-Binding Sites and Histone Modification in the Human ENCODE Regions. Genomics 89(2):178-88, 2007 [Epub 2006 Nov 3]
  16. Takahara Y, Takahashi M, Wagatsuma H, Yokoya F, Zhang QW, Yamaguchi M, Aburatani H, Kawada N. Gene expression profiles of hepatic cell-type specific marker genes in progression of liver fibrosis. World J Gastroenterol. 12(40):6473-99. 2006
  17. Hishinuma M, Ohashi KI, Yamauchi N, Kashima T, Uozaki H, Ota S, Kodama T, Aburatani H, Fukayama M. Hepatocellular oncofetal protein, glypican 3 is a sensitive marker for alpha-fetoprotein-producing gastric carcinoma. Histopathology. 49(5):479-86. 2006
  18. Hayashi H, Nagae G, Tsutsumi S, Kaneshiro K, Kozaki T, Kaneda A, Sugisaki H, Aburatani H. High-resolution mapping of DNA methylation in human genome using oligonucleotide tiling array. Hum Genet. 120(5):701-11, 2007 [Sep 26, 2006; Epub ahead of print]
  19. Guo Y, Chen Y, Ito H, Watanabe A, Ge X, Kodama T, Aburatani H. Identification and characterization of lin-28 homolog B (LIN28B) in human hepatocellular carcinoma. Gene. 384:51-61, 2006. Epub 2006 Jul 28.
  20. Liu H, Urabe K, Moroi Y, Yasumoto S, Kokuba H, Imafuku S, Koga T, Masuda T, Aburatani H, Furue M, Tu Y. Expression of p16 and hTERT protein is associated with the presence of high-risk human papillomavirus in Bowenoid papulosis. J Cutan Pathol. 33(8):551-8. 2006
  21. Choi YL, Tsukasaki K, O'neill MC, Yamada Y, Onimaru Y, Matsumoto K, Ohashi J, Yamashita Y, Tsutsumi S, Kaneda R, Takada S, Aburatani H, Kamihira S, Nakamura T, Tomonaga M, Mano H. A genomic analysis of adult T-cell leukemia. Oncogene. 26(8):1245-55. 2007 [Epub 2006 Aug 14.]
  22. Ota S, Hishinuma M, Yamauchi N, Goto A, Morikawa T, Fujimura T, Kitamura T, Kodama T, Aburatani H, Fukayama M. Oncofetal protein glypican-3 in testicular germ-cell tumor. Virchows Arch. 449(3):308-14. 2006
  23. Freeman JL, Perry GH, Feuk L, Redon R, McCarroll SA, Altshuler DM, Aburatani H, Jones KW, Tyler-Smith C, Hurles ME, Carter NP, Scherer SW, Lee C. Copy number variation: New insights in genome diversity. Genome Res. 16(8):949-61, 2006.
  24. Katou Y, Kaneshiro K, Aburatani H, Shirahige K. Genomic approach for the understanding of dynamic aspect of chromosome behavior. Methods Enzymol. 409:389-410. 2006
  25. Sakaki-Yumoto M, Kobayashi C, Sato A, Fujimura S, Matsumoto Y, Takasato M, Kodama T, Aburatani H, Asashima M, Yoshida N, Nishinakamura R. The murine homolog of SALL4, a causative gene in Okihiro syndrome, is essential for embryonic stem cell proliferation, and cooperates with Sall1 in anorectal, heart, brain and kidney development. Development. 133(15):3005-13. 2006
  26. Komura D, Nishimura K, Ishikawa S, Panda B, Huang J, Nakamura H, Ihara S, Hirose M, Jones KW, Aburatani H. Noise Reduction from genotyping microarrays using probe level information. In Silico Biol. 11;6(1-2):79-92, 2006
  27. Midorikawa Y, Yamamoto S, Ishikawa S, Kamimura N, Igarashi H, Sugimura H, Makuuchi M, Aburatani H. Molecular karyotyping of human hepatocellular carcinoma using single-nucleotide polymorphism arrays. Oncogene. 25(40):5581-90.2006
  28. Ito H, Funahashi S, Yamauchi N, Shibahara J, Midorikawa Y, Kawai S, Kinoshita Y, Watanabe A, Hippo Y, Ohtomo T, Iwanari H, Nakajima A, Makuuchi M, Fukayama M, Hirata Y, Hamakubo T, Kodama T, Tsuchiya M, Aburatani H. Identification of ROBO1 as a Novel Hepatocellular Carcinoma Antigen and a Potential Therapeutic and Diagnostic Target. Clin Cancer Res. 12(11):3257-64. 2006
  29. Kawamura-Saito M, Yamazaki Y, Kaneko K, Kawaguchi N, Kanda H, Mukai H, Gotoh T, Motoi T, Fukayama M, Aburatani H, Takizawa T, Nakamura T. Fusion between CIC and DUX4 up-regulates PEA3 family genes in Ewing-like sarcomas with t(4;19)(q35;q13) translocation. Hum Mol Genet. 15(13):2125-37.2006.
  30. Liu HJ, Moroi Y, Masuda T, Yasumoto S, Kokuba H, Imafuku S, Koga T, Tetsuya T, Tu YT, Aburatani H, Furue M, Urabe K. Expression of phosphorylated Stat3, cyclin D and Bcl-xL in extramammary Paget disease. Br J Dermatol. 154(5):926-32. 2006
  31. Goto Y, Matsuzaki Y, Kurihara S, Shimizu A, Okada T, Yamamoto K, Murata H, Takata M, Aburatani H, Hoon DS, Saida T, Kawakami Y. A new melanoma antigen Fatty Acid-binding protein 7, involved in proliferation and invasion, is a potential target for immunotherapy and molecular target therapy. Cancer Res. 66(8):4443-9. 2006
  32. Sheth SS, Bodnar JS, Ghazalpour A, Thipphavong CK, Tsutsumi S, Tward AD, Demant P, Kodama T, Aburatani H, Lusis AJ. Hepatocellular carcinoma in Txnip-deficient mice. Oncogene. 25(25):3528-36. 2006
  33. Yamada T, Ishihara H, Tamura A, Takahashi R, Yamaguchi S, Takei D, Tokita A, Satake C, Tashiro F, Katagiri H, Aburatani H, Miyazaki JI, Oka Y. WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic {beta}-cells. Hum Mol Genet. 15(10):1600-9. 2006
  34. Yamada T, Katagiri H, Ishigaki Y, Ogihara T, Imai J, Uno K, Hasegawa Y, Gao J, Ishihara H, Niijima A, Mano H, Aburatani H, Asano T, Oka Y. Signals from intra-abdominal fat modulate insulin and leptin sensitivity throｖugh different mechanisms: Neuronal involvement in food-intake regulation. Cell Metab.3(3):223-9. 2006
  35. Huang J, Wei W, Chen J, Zhang J, Liu G, Di X, Mei R, Ishikawa S, Aburatani H, Jones KW, Shapero MH. CARAT: A novel method for allelic detection of DNA copy number changes using high density oligonucleotide arrays. BMC Bioinformatics. 2006 Feb 21;7(1):83
  36. Yamamoto Y, Uehara A, Watanabe A, Aburatani H, Komiyama M. Chemical-Reaction-Based Site-Selective DNA Cutter for PCR-Free Gene Manipulation. Chembiochem. 7(4):673-677. 2006
  37. Yamashita K, Igarashi H, Kitayama Y, Ozawa T, Kiyose S, Konno H, Kazui T, Ishikawa S, Aburatani H, Tanioka F, Suzuki M, Sugimura H. Chromosomal Numerical Abnormality Profiles of Gastrointestinal Stromal Tumors. Jpn J Clin Oncol. 36(2):85-92, 2006
  38. Tanaka T, Jiang S, Hotta H, Takano K, Iwanari H, Sumi K, Daigo K, Ohashi R, Sugai M, Ikegame C, Umezu H, Hirayama Y, Midorikawa Y, Hippo Y, Watanabe A, Uchiyama Y, Hasegawa G, Reid P, Aburatani H, Hamakubo T, Sakai J, Naito M, Kodama T. Dysregulated expression of P1 and P2 promoter-driven hepatocyte nuclear factor-4alpha in the pathogenesis of human cancer. J Pathol. 208(5): 662-672. 2006.
  39. Chen Y, Guo Y, Ge X, Itoh H, Watanabe A, Fujiwara T, Kodama T, Aburatani H. Elevated expression and potential roles of human Sp5, a member of Sp transcription factor family, in human cancers. Biochem Biophys Res Commun. 340(3):758-66, 2006
  40. Aggarwal A, Li Guo D, Hoshida Y, Tsan Yuen S, Chu KM, So S, Boussioutas A, Chen X, Bowtell D, Aburatani H, Leung SY, Tan P. Topological and functional discovery in a gene coexpression meta-network of gastric cancer. Cancer Res. 66(1):232-41. 2006
  41. Nakajima H, Shibata F, Fukuchi Y, Goto-Koshino Y, Ito M, Urano A, Nakahata T, Aburatani H, Kitamura T. Immune suppressor factor confers stromal cell line with enhanced supporting activity for hematopoietic stem cells. Biochem Biophys Res Commun. 340(1):35-42. 2006
  42. Sasayama T, Kato M, Aburatani H, Kuzuya A, Komiyama M. Simultaneous Genotyping of Indels and SNPs by Mass Spectroscopy. J Am Soc Mass Spectrom. 17(1):3-8. 2006
  43. Takeda K, Yokoyama S, Aburatani H, Masuda T, Han F, Yoshizawa M, Yamaki N, Yamamoto H, Eguchi N, Urade Y, Shibahara S. Lipocalin-type prostaglandin D synthase as a melanocyte marker regulated by MITF. Biochem Biophys Res Commun. 339(4):1098-106. 2006
  44. Okawa H, Motohashi H, Kobayashi A, Aburatani H, Kensler TW, Yamamoto M. Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity. Biochem Biophys Res Commun 339(1):79-88, 2006
  45. Yamazaki S, Miki K, Takayama T, Hasegawa K, Sata M, Midorikawa Y, Aburatani H, Makuuchi M. Hepatic gene induction in murine bone marrow after hepatectomy. J Hepatol. 44(2):325-333. 2006

    46. ---2005

  46. Uehara A, Yamamoto Y, Watanabe A, Aburatani H, Komiyama M. Construction of chimera protein by using artificial restriction DNA cutter. Nucleic Acids Symp Ser (Oxf). 2005;(49):279-80.
  47. Yamamoto Y, Zhou JM, Tomita T, Uehara A, Aiba Y, Watanabe A, Aburatani H, Komiyama M. Gene manipulation using artificial restriction DNA cutter. Nucleic Acids Symp Ser (Oxf). 2005;(49):73-4.
  48. Matsubara D, Niki T, Ishikawa S, Goto A, Ohara E, Yokomizo T, Heizmann CW, Aburatani H, Moriyama S, Moriyama H, Nishimura Y, Funata N, Fukayama M. Differential expression of S100A2 and S100A4 in lung adenocarcinomas: Clinicopathological significance, relationship to p53 and identification of their target genes. Cancer Sci. 96(12):844-57. 2005
  49. Tauchi M, Hida A, Negishi T, Katsuoka F, Noda S, Mimura J, Hosoya T, Yanaka A, Aburatani H, Fujii-Kuriyama Y, Motohashi H, Yamamoto M. Constitutive expression of aryl hydrocarbon receptor in keratinocytes causes inflammatory skin lesions. Mol Cell Biol. 25(21):9360-8. 2005
  50. Mashima R, Saeki K, Aki D, Minoda Y, Takaki H, Sanada T, Kobayashi T, Aburatani H, Yamanashi Y, Yoshimura A. FLN29, a novel interferon- and LPS-inducible gene acting as a negative regulator of toll-like receptor signaling. J Biol Chem. 280(50):41289-97. 2005
  51. Aiba T, Kohu K, Ishidao T, Yasui N, Horii A, Aburatani H, Akiyama T. The mammalian homolog of the Drosophila discs large tumor suppressor protein up-regulates expression of the ELR(+) CXC chemokine Scyb5. Biochem Biophys Res Commun. 337(1):191-194, 2005
  52. Katsuoka F, Motohashi H, Ishii T, Aburatani H, Engel JD, Yamamoto M. Genetic Evidence that Small Maf Proteins Are Essential for the Activation of Antioxidant Response Element-Dependent Genes. Mol Cell Biol. 25(18):8044-51. 2005
  53. Hishiya A, Ito M, Aburatani H, Motoyama N, Ikeda K, Watanabe K. Ataxia telangiectasia mutated (Atm) knockout mice as a model of osteopenia due to impaired bone formation. Bone. 37(4):497-503. 2005
  54. Inamura K, Fujiwara T, Hoshida Y, Isagawa T, Jones MH, Virtanen C, Shimane M, Satoh Y, Okumura S, Nakagawa K, Tsuchiya E, Ishikawa S, Aburatani H, Nomura H, Ishikawa Y. Two subclasses of lung squamous cell carcinoma with different gene expression profiles and prognosis identified by hierarchical clustering and non-negative matrix factorization. Oncogene. 24(47):7105-13. 2005
  55. Yamashita S, Tanaka Y, Tsutsumi S, Aburatani H, Minato N, Ihara S. Analysis of mechanism for human gammadelta T cell recognition of nonpeptide antigens. Biochem Biophys Res Commun. 334(2):349-360. 2005
  56. Naito AT, Akazawa H, Takano H, Minamino T, Nagai T, Aburatani H, Komuro I. Phosphatidylinositol 3-Kinase-Akt Pathway Plays a Critical Role in Early Cardiomyogenesis by Regulating Canonical Wnt Signaling. Circ Res. 97(2):144-51. 2005
  57. Ishikawa S, Komura D, Tsuji S, Nishimura K, Yamamoto S, Panda B, Huang J, Fukayama M, Jones KW, Aburatani H. Allelic dosage analysis with genotyping microarrays. Biochem Biophys Res Commun. 333(4):1309-1314, 2005
  58. Yokoyama K, Higashi H, Ishikawa S, Fujii Y, Kondo S, Kato H, Azuma T, Wada A, Hirayama T, Aburatani H, Hatakeyama M. Functional antagonism between Helicobacter pylori CagA and vacuolating toxin VacA in control of the NFAT signaling pathway in gastric epithelial cells. Proc Natl Acad Sci U S A. 102(27):9661-6, 2005
  59. Tsuji AB, Sugyo A, Ogiu T, Sagara M, Kimura T, Ishikawa A, Sudo H, Ohtsuki M, Aburatani H, Imai T, Harada YN. Fine mapping of radiation susceptibility and gene expression analysis of LEC congenic rat lines. Genomics. 86(3):271-9 2005
  60. Ge X, Yamamoto S, Tsutsumi S, Midorikawa Y, Ihara S, Wang SM, Aburatani H. Interpreting expression profiles of cancers by genome-wide survey of breadth-of-expression in normal tissues. Genomics 86(2):127-141, 2005
  61. Yamauchi N, Watanabe A, Hishinuma M, Ohashi KI, Midorikawa Y, Morishita Y, Niki T, Shibahara J, Mori M, Makuuchi M, Hippo Y, Kodama T, Iwanari H, Aburatani H, Fukayama M.. The Glypican 3 oncofetal protein is a promising diagnostic marker for hepatocellular carcinoma. Modern Pathology 18(12):1591-8. 2005
  62. Shimamura T, Ito H, Shibahara J, Watanabe A, Hippo Y, Taniguchi H, Chen Y, Kashima T, Ohtomo T, Tanioka F, Iwanari H, Kodama T, Kazui T, Sugimura H, Fukayama M, Aburatani H. Overexpression of MUC13 is associated with intestinal-type gastric cancer. Cancer Sci. 96(5):265-73. 2005
  63. Yanagihara M, Ishikawa S, Naito M, Nakajima J, Aburatani H, Hatakeyama M. Paired-like homeoprotein ESXR1 acts as a sequence-specific transcriptional repressor of the human K-ras gene. Oncogene 24(38):5878-87. 2005.
  64. Kano M, Tsutsumi S, Kawahara N, Wang Y, Mukasa A, Kirino T, Aburatani H. A meta-clustering analysis indicates distinct pattern alteration between two series of Gene Expression profiles for induced ischemic tolerance in rats. Physiological Genomics. 21(2):274-83. 2005
  65. Liu HJ, Moroi S, Yasumoto S, Koga T, Masuda T, Chen QJ, Tu YT, Fure M, Aburatani H, Urabe K. Expression of elafin in extramammary Paget's disease. Br J Dermatol. 152(3):578-9. 2005
  66. Hanada T, Tanaka K, Matsumura Y, Yamauchi M, Nishinakamura H, Aburatani H, Mashima R, Kubo M, Kobayashi T, Yoshimura A. Induction of hyper Th1 cell-type immune responses by dendritic cells lacking the suppressor of cytokine signaling-1 gene. J Immunol. 174(7):4325-32. 2005
  67. Fukumoto S, Yamauchi N, Moriguchi H, Hippo Y, Watanabe A, Shibahara J, Taniguchi H, Ishikawa S, Ito H, Yamamoto S, Iwanari H, Hironaka M, Ishikawa Y, Niki T, Sohara Y, Kodama T, Nishimura M, Fukayama M, Dosaka-Akita H, Aburatani H. Overexpression of the Aldo-Keto Reductase Family Protein AKR1B10 Is Highly Correlated with Smokers' Non-Small Cell Lung Carcinomas. Clin Cancer Res. 11(5):1776-85 2005
  68. Capurro M, Filmus J, Hippo Y, Aburatani H, Sato H. Glypican-3 as a serum marker for hepatocellular carcinoma. Cancer Research 65(1):372; author reply 372-3. 2005
  69. Komura D, Nakamura H, Tsutsumi S, Aburatani H, Ihara S. Multidimensional support vector machines for visualization of gene expression data. Bioinformatics. 21(4):439-44. 2005
  70. Inozume T, Matsuzaki Y, Kurihara S, Fujita T, Yamamoto A, Aburatani H, Shimada S, Kawakami Y. Novel melanoma antigen, FCRL/FREB, identified by cDNA profile comparison using DNA chip are immunogenic in multiple melanoma patients. Int J Cancer. 114(2):283-90. 2005

    71. ---2004

  71. Midorikawa Y, Tsutsumi S, Nishimura K, Kamimura N, Kano M, Sakamoto H, Makuuchi M, Aburatani H. Distinct chromosomal bias of gene expression signatures in the progression of hepatocellular carcinoma. Cancer Res. 64(20): 7263-70. 2004
  72. Minami T, Horiuchi K, Miura M, Abid R, Takabe W, Kohro T, Ge X, Aburatani H, Hamakubo T, Kodama T, Aird WC. VEGF- and thrombin-induced termination factor, down syndrome critical region-1, attenuates endothelial cell proliferation, and angiogenesis. J Biol Chem. 279(48): 50537-54. 2004
  73. Miyachi H, Ikebukuro K, Yano K, Aburatani H, Karube I. Single nucleotide polymorphism typing on DNA array with hydrophobic surface fabricated by plasma-polymerization technique. Biosens Bioelectron. 20(2): 184-9. 2004
  74. Kamei Y, Miura S, Suzuki M, Kai Y, Mizukami J, Taniguchi T, Mochida K, Hata T, Matsuda J, Aburatani H, Nishino I, Ezaki O. Skeletal muscle FOXO1 (FKHR)-transgenic mice have less skeletal muscle mass, down-regulated type I (slow twitch / red muscle) fiber genes, and impaired glycemic control. J Biol Chem. 279(39): 41114-23. 2004
  75. Watanabe T, Akishita M, Nakaoka T, He H, Miyahara Y, Yamashita N, Wada Y, Aburatani H, Yoshizumi M, Kozaki K, Ouchi Y. Caveolin-1, Id3a and two LIM protein genes are upregulated by estrogen in vascular smooth muscle cells. Life Sci. 75(10): 1219-29. 2004
  76. Takasato M, Osafune K, Matsumoto Y, Kataoka Y, Yoshida N, Meguro H, Aburatani H, Asashima M, Nishinakamura R. Identification of kidney mesenchymal genes by a combination of microarray analysis and Sall1-GFP knockin mice. Mech Dev. 121(6): 547-57. 2004
  77. Kohro T, Tanaka T, Murakami T, Wada Y, Aburatani H, Hamakubo T, Kodama T. A Comparison of Differences in the Gene Expression Profiles of Phorbol 12-myristate 13-acetate Differentiated THP-1 Cells and Human Monocyte-derived Macrophage. J Atheroscler Thromb. 11(2): 88-97. 2004
  78. Ogihara T, Asano T, Katagiri H, Sakoda H, Anai M, Shojima N, Ono H, Fujishiro M, Kushiyama A, Fukushima Y, Kikuchi M, Noguchi N, Aburatani H, Gotoh Y, Komuro I, Fujita T. Oxidative stress induces insulin resistance by activating the nuclear factor-kappaB pathway and disrupting normal subcellular distribution of phosphatidylinositol 3-kinase. Diabetologia. 47(5): 794-805, 2004
  79. Takita J, Ishii M, Tsutsumi S, Tanaka Y, Kato K, Toyoda Y, Hanada R, Yamamoto K, Hayashi Y, Aburatani H.　Gene expression profiling and identification of novel prognostic marker genes in neuroblastoma. Genes Chromosomes Cancer. 40(2): 120-32. 2004
  80. Matsuo K, Galson DL, Zhao C, Peng L, Laplace C, Wang KZ, Bachler MA, Amano H, Aburatani H, Ishikawa H, Wagner EF. NFAT rescues osteoclastogenesis in precursors lacking c-Fos. J Biol Chem. 279(25): 26475-80. 2004
  81. Fujiwara K, Ochiai M, Ohta T, Ohki M, Aburatani H, Nagao M, Sugimura T, Nakagama H. Global gene expression analysis of rat colon cancers induced by a food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Carcinogenesis. 25(8): 1495-505. 2004
  82. Hippo Y, Watanabe K, Watanabe A, Midorikawa Y, Yamamoto S, Ihara S, Tokita S, Iwanari H, Ito Y, Nakano K, Nezu J, Tsunoda H, Yoshino T, Ohizumi I, Tsuchiya M, Ohnishi S, Makuuchi M, Hamakubo T, Kodama T, Aburatani H. Identification of Soluble Amino Terminal Fragment of Glypican-3 as a Serological Marker for Early Stage Hepatocellular Carcinoma. Cancer Research 64(7): 2418-2423. 2004
  83. Nakatani N, Aburatani H, Nishimura K, Semba J, Yoshikawa T. Comprehensive expression analysis of a rat depression model. Pharmacogenomics J. 4(2):114-26. 2004
  84. Mukasa A, Ueki K, Ge X, Ishikawa S, Ide T, Fujimaki T, Nishikawa R, Asai A, Kirino T, Aburatani H. Selective expression of a subset of neuronal genes in oligodendroglioma with chromosome 1p loss. Brain Pathology 14(1): 34-42. 2004
  85. Kawahara N, Wang Y, Mukasa A, Furuya K, Shimizu T, Hamakubo T, Aburatani H, Kodama T, Kirino T. Genome-wide Gene Expression Analysis for Induced Ischemic Tolerance and Delayed Neuronal Death Following Transient Global Ischemia in Rats. J Cereb Blood Flow Metab. 24(2): 212-223. 2004
  86. Joo A, Aburatani H, Morii E, Iba H, Yoshimura A.　STAT3 and MITF cooperatively induce cellular transformation through upregulation of c-fos expression. Oncogene. 23(3): 726-34. 2004

    87. ---2003

  87. Watanabe A, Hippo Y, Taniguchi H, Iwanari H, Yashiro M, Hirakawa K, Kodama T, Aburatani H.　An Opposing View on WWOX Protein Function as a Tumor Suppressor. Cancer Res. 63(24): 8629-8633. 2003
  88. Ge X, Tsustumi S, Aburatani H, Iwata S. Reducing false positives in molecular pattern recognition. Genome Inform Ser Workshop Genome Inform. 14:34-43, 2003
  89. Mizukami M, Hasegawa H, Kohro T, Toko H, Kudoh T, Zou YZ, Aburatani H, Komuro I. Gene expression profile revealed different effects of angiotensin II receptor blockade and angiotensin-converting enzyme inhibitor on heart failure. Journal of cardiovascular pharmacology 42: S1-S6, Suppl. 1 DEC 2003
  90. Matsuyama S, Iwadate M, Kondo M, Saitoh M, Hanyu A, Shimizu K, Aburatani H, Mishima HK, Imamura T, Miyazono K, Miyazawa K. SB-431542 and Gleevec Inhibit Transforming Growth Factor-beta-Induced Proliferation of Human Osteosarcoma Cells. Cancer Res. 63(22): 7791-7798. 2003
  91. Ye S, Liang X, Yamamoto Y, Zhou JM, Tomita T, Aburatani H, Komiyama M. Simultaneous detection of multiple single nucleotide polymorphism by single-strand-specific nuclease and PNA probe. Nucleic Acids Res Suppl. 2003;(3): 185-6.
  92. Matsui Y, Saiura A, Sugawara Y, Sata M, Naruse K, Yagita H, Kohro T, Mataki C, Izumi A, Yamaguchi T, Minami T, Sakihama T, Ihara S, Aburatani H, Hamakubo T, Kodama T, Makuuchi M.　Identificaton of gene expression profile in tolerizing murine cardiac allograft by co-stimulatory blockade. Physiol Genomics. 15(3): 199-208. 2003. Epub 2003 Sep 09
  93. Sugiyama D, Kusuhara H, Taniguchi H, Ishikawa S, Nozaki Y, Aburatani H, Sugiyama Y. Functional characterization of rat brain specific organic anion transporter (Oatp14) at the blood-brain barrier: High affinity transporter for thyroxine. J Biol Chem. 278(44): 43489-95, 2003
  94. Tsutsumi S, Taketani T, Nishimura K, Ge X, Taki T, Sugita K, Ishii E, Hanada R, Ohki M, Hayashi Y and Aburatani H. Two distinct gene expression signatures in pediatric acute lymphoblastic leukemia with MLL rearrangements. Cancer Research 63(16):4882-7, 2003
  95. Jiang S, Tanaka T, Iwanari H, Hotta H, Yamashita H, Kumakura J, Watanabe Y, Uchiyama Y, Aburatani H, Hamakubo T, Kodama T, Naito M. Expression and localization of P1 promoter-driven hepatocyte nuclear factor-4a (HNF4a) isoforms in human and rats. Nuclear Receptor 2003, 1:5
  96. Sekoguchi E, Sato N, Yasui A, Fukada S, Nimura Y, Aburatani H, Ikeda K, Matsuura A. A novel mitochondrial carnitine-acylcarnitine translocase induced by partial hepatectomy and fasting. J Biol Chem. 278: 38796 - 38802, 2003
  97. Ono R, Shiura H, Aburatani H, Kohda T, Kaneko-Ishino T, Ishino F. Identification of a large novel imprinted gene cluster on mouse proximal chromosome 6. Genome Res. 13(7):1696-705. 2003
  98. Satoh T, Baba M, Nakatsuka D, Ishikawa Y, Aburatani H, Furuta K, Ishikawa T, Hatanaka H, Suzuki M, Watanabe Y. Role of heme oxygenase-1 protein in the neuroprotective effects of cyclopentenone prostaglandin derivatives under oxidative stress. Eur J Neurosci. 17(11): 2249-2255. 2003
  99. Shimizu H, Taniguchi H, Hippo Y, Hayashizaki Y, Aburatani H, Ishikawa T. Characterization of the mouse Abcc12 gene and its transcript encoding an ATP-binding cassette transporter, an orthologue of human ABCC12. Gene. 310:17-28. 2003
  100. Chong JM, Sakuma K, Sudo M, Ushiku T, Uozaki H, Shibahara J, Nagai H, Funata N, Taniguchi H, Aburatani H, Fukayama M. Global and non-random CpG-island methylation in gastric carcinoma associated with Epstein-Barr virus. Cancer Sci. 94(1): 76-80. 2003
  101. Fujiwara Y、Yokoyama M、Sawada R、Seyama Y、Ishii M、Tsutsumi S、Aburatani H、Hanaka S、Itakura H、Matsumoto A. Analysis of comprehensive effects of polyunsaturated fatty acid on mRNA expression using a GeneChip. J Nutr Sci Vitaminol, 49: 125-132 2003
  102. Komiyama M, Ye S, Liang X, Yamamoto Y, Tomita T, Zhou JM, Aburatani H. PNA for One-Base Differentiating Protection of DNA from Nuclease and Its Use for SNPs Detection. J Am Chem Soc. 125(13): 3758-62. 2003
  103. Kashima T, Nakamura K, Kawaguchi J, Takanashi M, Ishida T, Aburatani H, Kudo A, Fukayama M, Grigoriadis AE. Overexpression of cadherins suppresses pulmonary metastasis of osteosarcoma in vivo. Int J Cancer. 104(2): 147-54. 2003
  104. Kano M, Nishimura K, Tsutsumi S, Aburatani H, Hirota K, and Hirose M. Cluster Overlap Distribution Map: Visualization for Gene Expression Analysis Using Immersive Projection Technology. Presence: Teleoperators and Virtual Environments 12(1): 96-109, 2003.
  105. Kano M, Nishimura K, Ishikawa S, Tsutsumi S, Hirota K, Hirose M, Aburatani H. Expression Imbalance Map: A New Visualization Method for Detection of mRNA Expression Imbalance Regions. Physiol Genomics. 13: 31-46, 2003
  106. Midorikawa Y, Ishikawa S, Iwanari H, Imamura T, Sakamoto H, Miyazono K, Kodama T, Makuuchi M, Aburatani H. Glypican-3, overexpressed in hepatocellular carcinoma, modulates FGF2 and BMP-7 signaling. Int J Cancer. 103(4): 455-65. 2003

    107. ---2002

  107. Higuchi A, Shimmura S, Ishii M, Aburatani H, Tsubota K. Serum- and serum deprivation-induced transcriptional profiles of cultured conjunctival epithelial cells. Adv Exp Med Biol. 2002; 506(Pt A): 673-6
  108. Nakajima A, Wada K, Katayama K, Saubermann L, Osawa E, Nagase H, Ueno N, Matsuhashi N, Aburatani H. Gene expression profile after peroxisome proliferator activator receptor-gamma ligand administration in dextran sodium sulfate mice. J Gastroenterol. 37 Suppl 14:62-6. 2002
  109. Ogihara T, Asano T, Ando K, Chiba Y, Sakoda H, Anai M, Shojima N, Ono H, Onishi Y, Fujishiro M, Katagiri H, Fukushima Y, Kikuchi M, Noguchi N, Aburatani H, Komuro I, Fujita T. Angiotensin II-Induced Insulin Resistance Is Associated With Enhanced Insulin Signaling. Hypertension 40(6): 872-9. 2002
  110. Yabuuchi H, Takayanagi S, Yoshinaga K, Taniguchi N, Aburatani H, Ishikawa T. ABCC13, an unusual truncated ABC transporter, is highly expressed in fetal human liver. Biochem Biophys Res Commun. 299(3): 410-7. 2002
  111. Saubermann LJ, Nakajima A, Wada K, Zhao S, Terauchi Y, Kadowaki T, Aburatani H, Matsuhashi N, Nagai R, Blumberg RS. Peroxisome proliferator-activated receptor gamma agonist ligands stimulate a Th2 cytokine response and prevent acute colitis. INFLAMMATORY BOWEL DISEASES 8: (5) 330-339. 2002
  112. Ota T, Fujii M, Sugizaki T, Ishii M, Miyazawa K, Aburatani H, Miyazono K. Targets of transcriptional regulation by two distinct type I receptors for transforming growth factor-beta in human umbilical vein endothelial cells. J Cell Physiol. 193(3): 299-318. 2002
  113. Fujiwara Y、Yokoyama M、Umeda-Sawada R、Seyama Y、Ishii M、Tsutsumi S、Aburatani H、Hanaka S、Itakura H、Matsumoto A. Influence of polyunsaturated fatty acid on gene expression in HepG2 cells. J Atheroscler Thromb 9(3): 157-162 2002 Review
  114. Chong JM, Sakuma K, Sudo M, Osawa T, Ohara E, Uozaki H, Shibahara J, Kuroiwa K, Tominaga SI, Hippo Y, Aburatani H, Funata N, Fukayama M. Interleukin-1beta Expression in Human Gastric Carcinoma with Epstein-Barr Virus Infection. J Virol. 76(13):6825-6831. 2002
  115. Saiura A, Kohro T, Yamamoto T, Izumi A, Wada Y, Aburatani H, Sugawara Y, Hamakubo T, Taniguchi T, Naito M, Kodama T, Makuuchi M. Detection of an up-regulation of a group of chemokine genes in murine cardiac allograft in the absence of interferon-gamma by means of DNA microarray1. Transplantation. 73(9): 1480-1486. 2002
  116. Midorikawa Y, Tsutsumi S, Taniguchi H, Ishii M, Kobune Y, Kodama T, Makuuchi M, Aburatani H. Identification of genes associated with dedifferentiation of hepatocellular carcinoma with expression profiling analysis. Jpn J Cancer Res. 93(6): 636-43 2002
  117. Hippo Y, Taniguchi H, Tsutsumi S, Machida N, Chong JM, Fukayama M, Kodama T, Aburatani H. Global gene expression analysis of gastric cancer by oligonucleotide microarrays. Cancer Research 62(1): 233-240, 2002
  118. Mukasa A, Ueki K, Matsumoto S, Tsutsumi S, Nishikawa R, Fujimaki T, Asai A, Kirino T, Aburatani H.: Distinction in gene expression profiles of oligodendrogliomas with and without allelic loss of 1p. Oncogene 21(25): 3961-8, 2002
  119. Takahashi M, Tsuboyama-Kasaoka N, Nakatani T, Ishii M, Tsutsumi S, Aburatani H, Ezaki O. Fish oil feeding alters liver gene expressions to defend against PPARalpha activation and ROS production. Am J Physiol Gastrointest Liver Physiol. 282(2): G338-48. 2002

    120. ---2001

  120. Takabe W, Kodama T, Hamakubo T, Tanaka K, Suzuki T, Aburatani H, Matsukawa N, Noguchi N. Anti-atherogenic antioxidants regulate the expression and function of proteasome -type subunits in human endothelial cells. J. Biol. Chem. 276(44): 40497-501, 2001
  121. Saiura A, Mataki C, Murakami T, Umetani M, Wada Y, Kohro T, Aburatani H, Harihara Y, Hamakubo T, Yamaguchi T, Hasegawa G, Naito M, Makuuchi M, Kodama T. A comparison of gene expression in murine cardiac allografts and isografts by means dna microarray analysis. Transplantation. 72(2): 320-9. 2001
  122. Akiyoshi S, Ishii M, Nemoto N, Kawabata M, Aburatani H, Miyazono K. Targets of Transcriptional Regulation by Transforming Growth Factor-beta: Expression Profile Analysis Using Oligonucleotide Arrays. Jpn J Cancer Res. 92(3): 257-268. 2001
  123. Hippo Y, Yashiro M, Ishii M, Taniguchi H, Tsutsumi S, Hirakawa K, Kodama T, Aburatani H. Differential gene expression profiles of scirrhous gastric cancer cells with highly metastatic potential to peritoneum or lymph nodes. Cancer Research 61: 889-895, 2001

    124. ---2000

  124. Kohro T, Nakajima T, Wada Y, Sugiyama A, Ishii M, Tsutsumi S, Aburatani H, Imoto I, Inazawa J, Hamakubo T, Kodama T and Emi M. Genomic structure and mapping of human orphan receptor LXR alpha: Upregulation of LXRa mRNA during monocyte to macrophage differentiation. Journal of Atherosclerosis and Thrombosis 7: 145-151, 2000
  125. Tsutsumi S, Kobune Y, Midorikawa Y and Aburatani H. Classification of Hepatocellular Carcinoma by Gene Expression Profiling Analysis. Genome Informatics 11: 240-241, 2000
  126. Suwa M, Sato T, Okouchi I, Mikoshiba M, Akiyama Y, Asai K, Matsumoto S, Tsutsumi S and Aburatani H. GeneDiscovery of G-Protein Coupled Receptors from Human Genome. Genome Informatics 11: 410-411, 2000
  127. Ge X, Yonamine S, Mi Y, Tsutsumi S, Kobune Y, Aburatani H and Iwata S. A Physics-Inspired algorithm for information visualization with application to gene expression analysis. Journal of the School of Engineering, The University of Tokyo, XLVII: 89-103, 2000
  128. Hiroi Y, Chen R, Sawa H, Hosoda T, Kudoh S, Kobayashi Y, Aburatani H, Nagashima K, Nagai R, Yazaki Y, Medof ME, Komuro I. Cloning of murine glycosyl phosphatidylinositol anchor attachment protein, GPAA1. Am J Physiol Cell Physiol 279(1): C205-12, 2000
  129. Abe-Dohmae S, Suzuki S, Wada Y, Aburatani H, Vance DE, and Yokoyama S. Characterization of Apolipoprotein-Mediated HDL Generation Induced by cAMP in a Murine Macrophage Cell Line. Biochemistry 39(36): 11092-9, 2000
  130. Ishii M, Hashimoto Si, Tsutsumi S, Wada Y, Matsushima K, Kodama T, Aburatani H. Direct comparison of GeneChip and SAGE on the quantitative accuracy in the transcript profiling analysis. Genomics 68(2): 136-43, 2000
  131. Murakami T, Mataki C, Nagao C, Umetani M, Wada Y, Ishii M, Tsutsumi S, Kohro T, Saiura A, Aburatani H, Hamakubo T and Kodama T. The gene expression profile of human umbilical vein endothelial cells stimulated by tumor necrosis factor a using DNA microarray analysis. Journal of Atherosclerosis and Thrombosis, 39-44, 2000
  132. Mataki C, Murakami T, Umetani M, Wada Y, Ishii M, Tsutsumi S, Aburatani H, Hamakubo T and Kodama T. (2000) A novel zinc finger protein mRNA in human umbilical vein endothelial cell is profoundly induced by tumor necrosis factorα. Journal of Atherosclerosis and Thrombosis 7:97-103, 2000
  133. Minowa O, Arai T, Hirano M, Monden Y, Nakai S, Fukuda M, Itoh M, Takano H, Hippo Y, Aburatani H, Masumura Ki, Nohmi T, Nishimura S, Noda T. Mmh/Ogg1 gene inactivation results in accumulation of 8-hydroxyguanine in mice. Proc Natl Acad Sci U S A. 97(8): 4156-61. 2000
  134. Asagoshi K, Yamada T, Terato H, Ohyama Y, Monden Y, Arai T, Nishimura S, Aburatani H, Lindahl T, Ide H. Distinct repair activities of human 7,8-dihydro-8-oxoguanine DNA glycosylase and formamidopyrimidine DNA glycosylase for formamidopyrimidine and 7,8-dihydro-8-oxoguanine. J Biol Chem. 275(7): 4956-64. 2000

    135. ---1999

  135. Ishida, T., Hippo, Y., Nakahori, Y., Matsushita, I., Kodama, T., Nishimura, S., and Aburatani, H. Structure and chromosomal localization of human MMH/OGG1 gene. Cytogenetics and Cell Genetics, 85(3-4):232-6. 1999
  136. Monden, Y., Arai, T., Asano, M., Ohtsuka, E., Aburatani, H., and Nishimura, S. Human MMH (OGG1) type 1a protein is a major enzyme for repair of 8- hydroxyguanine lesions in human cells. Biochem Biophys Res Commun 258, 605-10. 1999
  137. Ishida, T., Takashima, R., Fukayama, M., Hamada, C., Hippo, Y., Fujii, T., Moriyama, S., Matsuba, C., Nakahori, Y., Morita, H., Yazaki, Y., Kodama, T., Nishimura, S., and Aburatani H. New DNA polymorphisms of human MMH/OGG1 gene: prevalence of one polymorphism among lung-adenocarcinoma patients in Japanese. Int J Cancer 80, 18-21. 1999

    138. ---1998

  138. Ejeskar, K., Aburatani, H., Abrahamsson, J., Kogner, P., and Martinsson, T. Loss of heterozygosity of 3p markers in neuroblastoma tumours implicate a tumour-suppressor locus distal to the FHIT gene. Br J Cancer 77, 1787-91. 1998
  139. Takao, M., Aburatani, H., Kobayashi, K., and Yasui, A. Mitochondrial targeting of human DNA glycosylases for repair of oxidative DNA damage. Nucleic Acids Res 26, 2917-22. 1998
  140. Hiroi, Y., Komuro, I., Matsushita, I., Aburatani, H., Hosoda, T., Nakahori, Y., Medof, M. E., and Yazaki, Y. Assignment of the human GPAA1 gene, which encodes a product required for the attachment of glycosylphosphatidylinositols to proteins, at 8q24. Genomics 54, 354-5. 1998

    141. ---1997

  141. Hallstensson, K., Thulin, S., Aburatani, H., Hippo, Y., and Martinsson, T. Representational difference analysis and loss of heterozygosity studies detect 3p deletions in neuroblastoma. Eur J Cancer 33, 1966-70. 1997
  142. Aburatani, H., Hippo, Y., Ishida, T., Takashima, R., Matsuba, C., Kodama, T., Takao, M., Yasui, A., Yamamoto, K., and Asano, M. Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue. Cancer Res 57, 2151-6. 1997
  143. Doi, T., Minami, T., Itoh, M., Aburatani, H., Kawabe, Y., Kodama, T., Kondo, N., Satoh, Y., Asayama, T., and Imanishi, T. An alternative form of nucleolysin binds to a T-cluster DNA in the silencer element of platelet factor 4 gene. Biochem Biophys Res Commun 235, 625-30. 1997
  144. Suzuki, H., Kurihara, Y., Takeya, M., Kamada, N., Kataoka, M., Jishage, K., Ueda, O., Sakaguchi, H., Higashi, T., Suzuki, T., Takashima, Y., Kawabe, Y., Cynshi, O., Wada, Y., Honda, M., Kurihara, H., Aburatani, H., Doi, T., Matsumoto, A., Azuma, S., Noda, T., Toyoda, Y., Itakura, H., Yazaki, Y., Kodama, T., and et al. A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection. Nature 386, 292-6. 1997.

    145. ---1996

  145. Corless, C. L., Aburatani, H., Fletcher, J. A., Housman, D. E., Amin, M. B., and Weinberg, D. S. (1996). Papillary renal cell carcinoma: quantitation of chromosomes 7 and 17 by FISH, analysis of chromosome 3p for LOH, and DNA ploidy. Diagn Mol Pathol 5, 53-64.
  146. Aburatani H, Stanton VP Jr., and Housman DE. High-resolution physical mapping by combined Alu-hybridization/PCR screening: construction of a yeast artificial chromosome map covering 31 centimorgans in 3p21-p14. Proc Natl Acad Sci U S A 93, 4474-9. 1996.

    147. ---1995 以前

  147. Cai, W., Aburatani, H., Stanton, V. P., Jr., Housman, D. E., Wang, Y. K., and Schwartz, D. C. Ordered restriction endonuclease maps of yeast artificial chromosomes created by optical mapping on surfaces. Proc Natl Acad Sci U S A 92: 5164-8, 1995
  148. Hunter KW, Ontiveros SD, Watson ML, Stanton VP Jr, Gutierrez P, Bhat D, Rochelle J, Graw S, Ton C, Schalling M, Aburatani H, Brown SDM, Seldin MF, Housman DE. Rapid and efficient construction of yeast artificial chromosome contigs in the mouse genome with interspersed repetitive sequence PCR (IRS-PCR): generation of a 5-cM, > 5 megabase contig on mouse chromosome 1. Mamm Genome. 1994 Oct;5(10):597-607.
  149. Munroe DJ, Haas M, Aburatani H, et al. (1994) IRE-bubble PCR: a rapid method for efficient and representative amplification of human genomic DNA sequences from complex sources. Genomics 19: 506-14
  150. Haas M, Aburatani H, Stanton VP Jr, et al. (1993) Isolation and FISH mapping of 80 cosmid clones on the short arm of human chromosome 3. Genomics 16: 90-6
  151. Li FP, Decker HJ, Aburatani H, et al. (1993) Clinical and genetic studies of renal cell carcinomas in a family with a constitutional chromosome 3;8 translocation. Genetics of familial renal carcinoma. Ann Intern Med 118: 106-11
  152. Brook JD, McCurrach ME, Harley HG, Buckler AJ, Church D, Aburatani H, Hunter K, Stanton VP, Thirion JP, Hudson T, et al. (1992) Molecular basis of myotonic distrophy: expansion of a trinucleotide (CTG) repeat at the 3' end of a transcript encoding a protein kinase family member. Cell 69: 385
  153. Hubert R, Stanton VP Jr, Aburatani H, et al. Sperm typing allows accurate measurement of the recombination fraction between D3S2 and D3S3 on the short arm of human chromosome 3. Genomics 12: 683-7. 1992
  154. Naganawa S, kodama T, Aburatani H, et al. Genetic analysis of a Japanese family with normotriglyceridemic abetalipoproteinemia indicates a lack of linkage to the apolipoprotein B gene. Biochem Biophys Res Commun 182: 99-104. 1992
  155. Goradia TM, Stanton VP Jr, Cui XF, Aburatani H, et al. Ordering three DNA polymorphisms on human chromosome 3 by sperm typing. Genomics 10: 748-55, 1991
  156. Gogos JA, Aburatani H, et al. Detection of single base mismatches of thymine and cytosine residues by potassium permanganate and hydroxylamine in the presence of tetralkylammonium salts. Nucleic Acids Res. 18(23): 6807-6814. 1990
  157. Matsumoto A, Naito M, Itakura H, Ikemoto S, Asaoka H, Hayakawa I, Kanamori H, Aburatani H, Takaku F, Suzuki H, et al. Human macrophage scavenger receptors: primary structure, expression, and localization in atherosclerotic lesions. Proc Natl Acad Sci U S A. 87(23): 9133-9137. 1990
  158. Ishikawa T, Aburatani H, et al. A functional retinoic acid receptor encoded by the gene on human chromosome 12. Mol Endocrinol. 4(6): 837-844. 1990
  159. Aburatani H, et al. Single base substitution between human intestinal and hepatic apolipoprotein B mRNA detected by ribonuclease cleavage analysis. J Biochem (Tokyo).105(6): 911-915. 1989
  160. Ohno M, Aburatani H, et al. A neonatal case of apolipoprotein C-II deficiency. Eur J Pediatr. 148(6): 550-552. 1989
  161. Shimano H, Aburatani H, et al. Down-regulation of hepatic LDL receptor protein and messenger RNA in fasted rabbits. J Biochem (Tokyo). 104(5): 712-716. 1988
  162. Aburatani H, et al. Increased levels of messenger ribonucleic acid for apolipoprotein E in the spleen of probucol-treated rabbits. Am J Cardiol. 62(3): 60B-65B. 1988
  163. Aburatani H, et al. A study of DNA polymorphism in the apolipoprotein B gene in a Japanese population. Atherosclerosis 72: 71-76. 1988
  164. Aburatani H, et al. Deoxyribonucleic Acid (DNA) Polymorphism in the Apolipoprotein AI Gene:A Study in a Japanese Population. Japanese Journal of Medicine, 27: 26-59. 1988
  165. Aburatani H, et al. Apolipoprotein B-gene polymorphism and myocardial infarction. New England J Med, 317: 52-53. 1987
  166. Matsumoto A, Aburatani H, et al. Cloning and regulation of rat apolipoprotein B mRNA. Biochem Biophys Res Comm 142: 92-99. 1987
  167. Ishikawa T, Aburatani H, et al. Primary intrahepatic sclerosing cholangitis with inflamatory bowel disease. Acta Patol.Jpn. 37: 1637-1643. 1987
  168. Takashima Y, Kodama T, Aburatani H, et al. Normotriglycedemic Abetalipoproteinemia in Infancy: An isolated Apolipoproteinemia B-100 Deficiency. Pediartrics, 75, 541-546. 1985
  169. Aburatani H, et al. Analysis of Apolipoproteins B100 and B48 by Sodium Dodesyl Sulfate Polyacrylamide Gradient Gel Electrophoresis. J.Biochem. 94: 1241-1245. 1983
  170. Kodama T, Akanuma Y, Okazaki M and Aburatani H, et al. Abnormalities in plasma lipoprotein in familial partial lecithin:cholesterol acyltransferase deficiency. Biochim Biophys Acta, 752:407-415. 1983

    欧文総説

  171. Aburatani H. Understanding cancer through gene expression profiling. (review) International Congress Series 1246: 261-270, 2002
  172. Aburatani H. Discovery of a new biomarker for gastroenterological cancers. J Gastroenterol. 40 Suppl 16:1-6. 2005
  173. Osaka N, Matsuzawa A, Takahashi T, Moriyama K, Aburatani H, Takeda K, Ichijo H. Physiological roles of stress-activated protein kinases in skin. International Congress Series 1284: 305-309, 2005
  174. Katou Y, Kaneshiro K, Aburatani H. and Shirahige K. Genomic Approach for the Understanding of Dynamic Aspect of Chromosome Behavior. in Methods in Enzymology, "DNA repair", Vol.409, Chapter 23, P. Modrich and J. Campbell (eds.). Elsevier Life Sciences (CA), in press (2006)