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We are seeking highly motivated PhD students who have a general interest in molecular biology, biochemistry, and/or bioinformatics.
Laboratory for Systems Biology and Medicine (LSBM) is the pioneering research center in Japan, which unifies the study of genes, proteins, cellular traffickings, and bioinformatics. Research at LSBM is geared towards comprehensive elucidation of the 'life system'. We have a particular interest in the molecular pathogenesis of cancer, arteriosclerosis and various metabolic disorders, and are intimately involved in the development of novel therapeutics and diagnostic methods.
Previous PhD graduates have published in numerous internationally recognized scientific journals, including Nature, PNAS, and JBC, and have accepted post-doctoral positions at leading academic universities and institutes, such as MIT, Harvard University, University of Texas Southwestern and the Pasteur Research Institute in France.
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For application forms or more information
please visit our website at http://www.lsbm.org
Informal mail enquiries can be addressed to Rina Doi (student@lsbm.org);
LSBM, RCAST, the Univ. of Tokyo
4-6-1 #34 Komaba, Meguro Tokyo, 153-8904 Japan
Fax: +81-3-5452-5232
Now, we are pleased to announce the availability of LSBM's scholarship. The restricted recipients would be highly motivated individuals who are looking for the opportunity to study at the LSBM with financial supports. (see below in details)
Guide to apply for the LSBM scholarship
Applicants can mail the following to the address given below (WE CANNOT ACCEPT FAXES OF THE FORM):
1) Curriculum Vitae
2) A copy of TOEFL score card (It is also required to enter the graduate school of Department of Advanced Interdisciplinary Studies)
3) Your research experience and interests (up to 1000 words)
4) Recommendation letter
5) Any other supplementary information (if you have)
Attn: Rina Doi
LSBM, RCAST, the Univ. of Tokyo
4-6-1#34 Komaba Meguro, Tokyo 153-8904
Tel: +81-3-5452-5230
Fax: +81-3-5452-5232
Closing date for the scholarship applications is the end of June 2004
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faculty member
| Tatsuhiko Kodama： |
Researchers in this laboratory analyze the gene expression of cells in the blood vessel and reconstitute the cell-based model for the analysis of atherosclerosis. They also study the normal and abnormal metabolism of cholesterol and glucose in the blood vessel and will develop drugs for the treatment of the highly prevalent diseases associated with the pathologies of these metabolic pathways.
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| Hiroyuki Aburatani： |
The Cancer System Lab Researchers in this laboratory analyze the global expression profile of the more than 30,000 genes involved in cancers of the liver, stomach and lung. They focus on the genes most important for the elucidation of the pathogenesis of these types of cancer, as well as important target proteins for diagnostics and therapeutics.
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| Hitoshi Nomura： |
Selection of best therapeutic targets of various proliferative diseases by elucidating aberrant networks of transcriptional regulation that cause aberrant gene expression profiles in respective diseases.
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| Takashi Minami： |
Researchers in this laboratory analyze the time-dependent changes in gene expression profiles. They will elucidate the changes in the transcriptional machinery which activate and constrain gene expression. Transcriptional factors which are identified will be targets for drug development.
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| Noriko Noguchi |
Various physicochemical stimuli will be employed to generate changes in gene expression. From an analysis of these changes, the researcher in this laboratory will dissect the mechanisms by which a biological stress mimicking the pathological trigger can be induced.
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| Yoshikazu Shibasaki： |
Proteins inside the cell form particular compartments with lipid structures which govern their intracellular movement and hence the transmission of information. The researchers in this laboratory dissect the principle pathways of membrane trafficking and use this information for the development of novel therapeutics.
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| Takao Hamakubo： |
The researchers in this laboratory develop universal expression methods for functional membrane protein systems. Many membrane proteins, including the GPCR, channeling proteins and transporters, are currently being expressed in this laboratory, and monoclonal antibodies against these proteins have been established.
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| Toshiko Sakihama： |
The researchers in this laboratory are developing a method for the functional reconstitution of the membrane protein complex. They are also developing a method for the detection of ligand binding and signaling using FRET technology and electrochemical methods.
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| Sigeo Ihara： |
The researchers in this laboratory are developing technologies for clustering, profiling, pathway analysis, and integration of the gene and protein databases. They are also developing a system for the rapid integration of information in the literature, especially those on the web, with the experimental results obtained in this institute.
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| Hisashi Moriguchi： |
The researchers in this laboratory analyze the importance and effectiveness of the diagnostics and therapeutics from the standpoint of both scientific merit and economical sustainability.
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