Staff
The Metabolic Medicine Lab.
Professor
Juro SAKAI

Publication List

  1. Takahashi S, Kawarabayasi Y, Nakai T, Sakai J, Yamamoto T: Rabbit very low density lipoprotein receptor: a low density lipoprotein receptor-like protein with distinct ligand specificity. Proc Natl Acad Sci U S A, 89, 9252-9256. (1992)
  2. Sakai J, Hoshino A, Takahashi S, Miura Y, Ishii H, Suzuki H, Kawarabayasi Y, Yamamoto T: Structure, chromosome location, and expression of the human very low density lipoprotein receptor gene. J Biol Chem, 269, 2173-2182. (1994)
  3. Hua X, Sakai J, Ho YK, Goldstein JL, Brown MS: Hairpin orientation of sterol regulatory element-binding protein-2 in cell membranes as determined by protease protection. J Biol Chem, 270, 29422-29427. (1995)
  4. Hua X, Sakai J, Brown MS, Goldstein JL: Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane. J Biol Chem, 271, 10379-10384. (1996)
  5. Kim DH, Iijima H, Goto K, Sakai J, Ishii H, Kim HJ, Suzuki H, Kondo H, Saeki S, Yamamoto T: Human apolipoprotein E receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain. J Biol Chem, 271, 8373-8380. (1996)
  6. Sakai J, Duncan EA, Rawson RB, Hua X, Brown MS, Goldstein JL: Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment. Cell, 85, 1037-1046. (1996)
  7. Wang X, Zelenski NG, Yang J, Sakai J, Brown MS, Goldstein JL: Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis. EMBO J, 15, 1012-1020. (1996)
  8. Duncan EA, Brown MS, Goldstein JL, Sakai J: Cleavage site for sterol-regulated protease localized to a leu-Ser bond in the lumenal loop of sterol regulatory element-binding protein-2. J Biol Chem, 272, 12778-12785. (1997)
  9. Rawson RB, Zelenski NG, Nijhawan D, Ye J, Sakai J, Hasan MT, Chang TY, Brown MS, Goldstein JL: Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs. Molecular Cell, 1, 47-57. (1997)
  10. Sakai J, Nohturfft A, Cheng D, Ho YK, Brown MS, Goldstein JL: Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein. J Biol Chem, 272, 20213-20221. (1997)
  11. Duncan EA, Dave UP, Sakai J, Goldstein JL, Brown MS: Second-site cleavage in sterol regulatory element-binding protein occurs at transmembrane junction as determined by cysteine panning. J Biol Chem, 273, 17801-17809. (1998)
  12. Iijima H, Miyazawa M, Sakai J, Magoori K, Ito MR, Suzuki H, Nose M, Kawarabayasi Y, Yamamoto TT: Expression and characterization of a very low density lipoprotein receptor variant lacking the O-linked sugar region generated by alternative splicing. J Biochem (Tokyo), 124, 747-755. (1998)
  13. Lund EG, Kerr TA, Sakai J, Li WP, Russell DW: cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism. J Biol Chem, 273, 34316-34327. (1998)
  14. Sakai J, Rawson RB, Espenshade PJ, Cheng D, Seegmiller AC, Goldstein JL, Brown MS: Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells. Molecular Cell, 2, 505-514. (1998)
  15. Sakai J, Nohturfft A, Goldstein JL, Brown MS: Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies. J Biol Chem, 273, 5785-5793. (1998)
  16. Fujino T, Takei YA, Sone H, Ioka RX, Kamataki A, Magoori K, Takahashi S, Sakai J, Yamamoto TT: Molecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product. J Biol Chem, 276, 35961-35966. (2001)
  17. Ikeda Y, Yamamoto J, Okamura M, Fujino T, Takahashi S, Takeuchi K, Osborne TF, Yamamoto TT, Ito S, Sakai J: Transcriptional regulation of the murine acetyl-CoA synthetase 1 gene through multiple clustered binding sites for sterol regulatory element-binding proteins and a single neighboring site for Sp1. J Biol Chem, 276, 34259-34269. (2001)
  18. Kosaka S, Takahashi S, Masamura K, Kanehara H, Sakai J, Tohda G, Okada E, Oida K, Iwasaki T, Hattori H, Kodama T, Yamamoto T, Miyamori I: Evidence of macrophage foam cell formation by very low-density lipoprotein receptor: interferon-gamma inhibition of very low-density lipoprotein receptor expression and foam cell formation in macrophages. Circulation, 103, 1142-1147. (2001)
  19. Gong JS, Sawamura N, Zou K, Sakai J, Yanagisawa K, Michikawa M: Amyloid beta-protein affects cholesterol metabolism in cultured neurons: implications for pivotal role of cholesterol in the amyloid cascade. J Neurosci Res, 70, 438-446. (2002)
  20. Kamataki A, Takahashi S, Masamura K, Iwasaki T, Hattori H, Naiki H, Yamada K, Suzuki J, Miyamori I, Sakai J, Fujino T, Yamamoto TT: Remnant lipoprotein particles are taken up into myocardium through VLDL receptor-a possible mechanism for cardiac fatty acid metabolism. Biochem Biophys Res Commun, 293, 1007-1013. (2002)
  21. Fujino T, Asaba H, Kang MJ, Ikeda Y, Sone H, Takada S, Kim DH, Ioka RX, Ono M, Tomoyori H, Okubo M, Murase T, Kamataki A, Yamamoto J, Magoori K, Takahashi S, Miyamoto Y, Oishi H, Nose M, Okazaki M, Usui S, Imaizumi K, Yanagisawa M, Sakai J (corresponding author), Yamamoto TT: Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion. Proc Natl Acad Sci U S A, 100, 229-234. (2003)
  22. Ioka RX, Kang MJ, Kamiyama S, Kim DH, Magoori K, Kamataki A, Ito Y, Takei YA, Sasaki M, Suzuki T, Sasano H, Takahashi S, Sakai J, Fujino T, Yamamoto TT: Expression Cloning and Characterization of a Novel Glycosylphosphatidylinositol-anchored High Density Lipoprotein-binding Protein, GPI-HBP1. J Biol Chem, 278, 7344-7349. (2003)
  23. Magoori K, Kang MJ, Ito MR, Kakuuchi H, Ioka RX, Kamataki A, Kim DH, Asaba H, Iwasaki S, Takei YA, Sasaki M, Usui S, Okazaki M, Takahashi S, Ono M, Nose M, Sakai J, Fujino T, Yamamoto TT: Severe hypercholesterolemia, impaired fat tolerance, and advanced atherosclerosis in mice lacking both low density lipoprotein receptor-related protein 5 and apolipoprotein E. J Biol Chem, 278, 11331-11336. (2003)
  24. Tanaka, T., Yamamoto, J., Iwasaki, S., Asaba, H., Yanagisawa. M., Kodama, T., and Sakai J.: Activation of Peroxisome Proliferator-Activated Receptor d Induces Fatty Acid b-oxidation in Skeletal Muscle and Attenuates Diet-Induced Obesity and Insulin Resistance. Proc Natl Acad Sci U S A, 15924-15929 (2003).
  25. Yamamoto J, Ikeda Y, Iguchi H, Fujino T, Tanaka T, Asaba H, Iwasaki S, Ioka RX, Kaneko IW, Magoori K, Takahashi S, Mori T, Sakaue H, Kodama T, Yanagisawa M, Yamamoto TT, Ito S, Sakai J: A Kruppel-like factor KLF 15 Contributes Fasting-Induced Transcriptional Activation of Mitochondrial Acetyl-CoA synthetase gene, AceCS2. J Biol Chem. In press (Short reports)
  26. Jokinen E, Sakai J, Yamamoto T, Hobbs HH: CGG triple repeat polymorphism in VLDL receptor (VLDL-R) gene. Hum Mol Genet, 3, 521. (1994) 27. Yamamoto T, Sakai J: The VLDL receptor and related molecules: Role and function. Atherosclerosis, X, 457-460. (1995) (Reviews)
  27. Yamamoto T, Takahashi S, Sakai J, Kawarabayasi Y: The VLDL receptor: A second lipoprotein receptor that may mediate uptake of fatty acids into muscle and fat cells. Trends Cardiovasc. Med., 3, 144-148. (1993)
  28. Yamamoto T, Hoshino A, Takahashi S, Kawarabayasi Y, Iijima H, Sakai J: The role of the very low density lipoprotein receptor in the metabolism of plasma lipoproteins containing ApoE. Ann N Y Acad Sci, 748, 217-224; discussion 224-225. (1995)
  29. Sakai J, Rawson RB: The sterol regulatory element-binding protein pathway: control of lipid homeostasis through regulated intracellular transport. Curr Opin Lipidol, 12, 261-266. (2001)
  30. Takahashi S, Sakai J, Fujino T, Miyamori I, Yamamoto TT: The very low density lipoprotein (VLDL) receptor--a peripheral lipoprotein receptor for remnant lipoproteins into fatty acid active tissues. Mol Cell Biochem, 248, 121-127. (2003)
  31. Fujino T, Ikeda Y, Osborne TF, Takahashi S, Yamamoto TT, Sakai J: Source of Acetyl-CoA Synthetase 1 and 2. Curr. Med. Chem., 3, 207-210 (2003)