Researchers in this laboratory analyze the gene expression of cells in the blood vessel and reconstitute the cell-based model for the analysis of atherosclerosis. They also study the normal and abnormal metabolism of cholesterol and glucose in the blood vessel and will develop drugs for the treatment of the highly prevalent diseases associated with the pathologies of these metabolic pathways.

The Cancer System Lab Researchers in this laboratory analyze the global expression profile of the more than 30,000 genes involved in cancers of the liver, stomach and lung. They focus on the genes most important for the elucidation of the pathogenesis of these types of cancer, as well as important target proteins for diagnostics and therapeutics.

Selection of best therapeutic targets of various proliferative diseases by elucidating aberrant networks of transcriptional regulation that cause aberrant gene expression profiles in respective diseases.

Researchers in this laboratory analyze the time-dependent changes in gene expression profiles. They will elucidate the changes in the transcriptional machinery which activate and constrain gene expression. Transcriptional factors which are identified will be targets for drug development.

Various physicochemical stimuli will be employed to generate changes in gene expression. From an analysis of these changes, the researcher in this laboratory will dissect the mechanisms by which a biological stress mimicking the pathological trigger can be induced.

Proteins inside the cell form particular compartments with lipid structures which govern their intracellular movement and hence the transmission of information. The researchers in this laboratory dissect the principle pathways of membrane trafficking and use this information for the development of novel therapeutics.

The researchers in this laboratory develop universal expression methods for functional membrane protein systems. Many membrane proteins, including the GPCR, channeling proteins and transporters, are currently being expressed in this laboratory, and monoclonal antibodies against these proteins have been established.

The researchers in this laboratory are developing a method for the functional reconstitution of the membrane protein complex. They are also developing a method for the detection of ligand binding and signaling using FRET technology and electrochemical methods.