We are working to develop systems biology and medicine to understand biological systems by functional genomics approach. Novel technology and new types of algorithms are required for collecting, integrating and visualizing the enormous amount of data on gene expression, protein expression, and protein interactions arising in the wake of the Human Genome Project. Alliance with outside academics and industries will be crucial to the success of the new "systems biology", i.e., understanding biological systems as more than the sum of their parts.

1. Systems biology of cancer: We have explored key molecules involved in carcinogenesis, through global analysis of gene expression, especially liver, lung and stomach cancer as major lethal cancers in Japan.
2. Technology development for genomic data acquisition: Novel analytical methods are being developed for gene copy number analysis and transcription factor binding.
3. Identification of novel biomarkers: Functional genomic approaches are applied to identify novel biomarkers for disease diagnostics and therapeutics.
4. Bioinformatics: The aim of this project is to reveal biological events in diseases with bioinformatics approach through integration of our proprietary gene expression data with public database of genome, transcriptome and ontogenic information.

Genome Science Division,RCAST,The Univ.of Tokyo