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| Decoding complex human systems |
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Systems biology and medicine - beyond the science of the genome and on to the post-genomic sciences.
The Progress of genome science indicates that at the best current estimate there are approximately 39,000 human genes. Proteomics, which is the key to post-genome science, is faced with the challenge of not only solving more than 100,000 proteins structure encoding by these genes, but also interpreting the function of these proteins and their role in pathogenesis.
LSBM (The Laboratory for Systems Biology and Medicine) is the worldÕs first laboratory dedicated to the analysis of complex living systems by the integration of 4 basic technologies: genomics, proteomics, transcriptomics,and the study of cell-cell interactions.
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From individual gene research to the research of biological network.
| Why is systems biology needed to understand life, health and disease? From genome analysis, it has become understood that many genes function not in isolation, but redundantly and/or in interelation with one another. Accordingly, there are many phenomena which can not be solved by either knockout or transgenic technology, as valuable as these approaches are. At LSBM, we have been able to successfully compile a very large amount of data obtained from a comprehensive analysis of gene expression profiles. Using these data we have developed methods for systematic information analysis. As a result, we have been compelled to the recognition that individual genes are not regulated randomly or as singular units apart from one another, but, on the contrary, are regulated by the overlap of many feedback loops in the system. By integrating systems biology and medical science LSBM aims at the elucidatation of this complex network of interactions. |
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Cancer and atherosclerosis as targets for genome based drug development
| As the system under study complexifies, the amount of comprehensive analysis data increases substantially, and significant resources, e.g. manpower, and funding are therefore needed for construction and maintenance of the corresponding database. However, on the other hand, systems biology and medical science working together are uniquely able to identify and/or clarify the highest value targets for the pharmaceutical, environment, food, cosmetics and other industries. For example, in the pharmaceutical industry, this multidisciplinary approach is able to develop drugs for target proteins at the greatest speed and at the lowest cost. We provide the technological solution for bridging the in-parallel progress of life science and information technology for the industry. |
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