The Laboratory for System Biology and Medicine (LSBM) consists of four divisions which are aimed at dissecting the pathogenesis of cancer and atherosclerosis, diseases which are major causes of death and debility in many industrialized countries. Using this information, we can research and develop novel diagnostics and therapeutics from the tremendous amount of novel biomedical data.Complete diagnosis and potential cures for cancer and arteriosclerosis.

Selection of a cell based model system In order to acquire large sets of relevant data, researchers will identify the cells responsible for the development of diseases and establish cell-based model systems

Global analysis of the temporal and spatial profiles of gene expression and protein localization Using cell-based systems, we are pinpointing changes in the gene expression profile in detail. Time dependent gene expression changes, and changes in the localization of proteins are two major information sets crucial to a systems approach.

Creating an integrated database The data acquired in our various laboratories is integrated into a single database. A large number of novel targets for drug development are emerging from this huge amount of high impact, cross-referencing data.

Development of diagnostics and therapeutics as an open laboratory. Drug target genes and proteins are expressed and monoclonal antibodies against these proteins are being generated by an orchestrated effort of both industrial and academic researchers whose various forms of expertise have been chosen especially for how they complement each other and this multidisciplinary process.

Mission (not yet)

Each Laboratory (not yet)