Pattern recognition receptor in innate immunity

Pattern recognition receptor in innate immunity

We have found that PTX3, a soluble pattern recognition receptor in innate immunity, forms strong bonds with histones leading to a disordered aggregation of histone and protecting human endothelial cells from damage. Mice treated with PTX3 recovered from sepsis, showing that treatment with PTX3 is a possible therapy not only for this condition, but also for ‘sterile’ sepsis induced by trauma, burn, ischemia, or hemorrhage, which also result in inflammation.