Regulation of adipocytes epigenome by nutritional environment

Regulation of adipocytes epigenome by nutritional environment

White adipocytes uptake glucose in the the blood and store as lipids when excess energy is ingested. When energy is insufficient, adipocytes catabolize stored lipid to supply energy to other cells. By analysis of metabolome, transcriptome, and epigenome during differentiation of white adipocytes, we are going to reveal part of the mechanism by which glucose-derived cellular metabolites re-write epigenome on genes involved in glucose matabolism. Through clarifying the regulatory system of epigenome in adipocytes via nutritional environment, we aim to prevent and treat lifestyle-related diseases by controlling glucose and lipid metabolism.