White adipocytes uptake glucose in the the blood and store as lipids when excess energy is ingested. When energy is insufficient, adipocytes catabolize stored lipid to supply energy to other cells. By analysis of metabolome, transcriptome, and epigenome during differentiation of white adipocytes, we are going to reveal part of the mechanism by which glucose-derived cellular metabolites re-write epigenome on genes involved in glucose matabolism. Through clarifying the regulatory system of epigenome in adipocytes via nutritional environment, we aim to prevent and treat lifestyle-related diseases by controlling glucose and lipid metabolism.
Matsumura Y, Nakaki R, Inagaki T, Yoshida A, Kano Y, Kimura H, Tanaka T, Tsutsumi S, Nakao M, Doi T, Fukami K, Osborne TF, Kodama T, Aburatani H, Sakai J. H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-Specific DNA Methylation Pauses Adipocyte Differentiation. Mol Cell. 2015 Nov 19;60(4):584-96. doi: 10.1016/j.molcel.2015.10.025.
Inagaki T, Iwasaki S, Matsumura Y, Kawamura T, Tanaka T, Abe Y, Yamasaki A, Tsurutani Y, Yoshida A, Chikaoka Y, Nakamura K, Magoori K, Nakaki R, Osborne TF, Fukami K, Aburatani H, Kodama T, Sakai J. The FBXL10/KDM2B scaffolding protein associates with novel polycomb repressive complex-1 to regulate adipogenesis. J Biol Chem. 2015 Feb 13;290(7):4163-77. doi: 10.1074/jbc.M114.626929. Epub 2014 Dec 22.