Phosphorylation of histone demethylase JMJD1A by acute cold stimuli is important for thermogenesis in brown adipocytes that are abundant in newborn babies (Nat Commun 2015). Upon chronic cold stimulation, adipose tissue produces beige adipocytes, which burn fat and produce heat, in a process referred to as “beige-ing”. Focusing on phosphorylated JMJD1A, we are analysing proteome, transcriptome, and epigenome during beige-ing to reveal the mechanisims for cold sensing and epigenome re-writing. Furthermore, we will clarify the mechanims for JMJD1A phospohrylation and dephosphorylation to propose a new treatment strategy of lifestyle-related disease by induction of beige-ing.
Inagaki T, Sakai J, Kajimura S. Transcriptional and epigenetic control of brown and beige adipose cell fate and function. Nat Rev Mol Cell Biol. 2016 Aug;17(8):480-95. doi: 10.1038/nrm.2016.62. Epub 2016 Jun 2. Review.
Abe Y, Rozqie R, Matsumura Y, Kawamura T, Nakaki R, Tsurutani Y, Tanimura-Inagaki K, Shiono A, Magoori K, Nakamura K, Ogi S, Kajimura S, Kimura H, Tanaka T, Fukami K, Osborne TF, Kodama T, Aburatani H, Inagaki T, Sakai J. JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis. Nat Commun. 2015 May 7;6:7052. doi: 10.1038/ncomms8052.