Design and evaluation using molecular dynamics simulation in development of Cupid-Psyche systems

Design and evaluation using molecular dynamics simulation in development of Cupid-Psyche systems

In this project, we are developing a pre-targeting method, which is one of the treatments for cancer, using humanized streptobidin (codon: Cupid) and artificial biotin (codename: Psyche (Psyche)), which is humanized and reduced in antigenicity. In our group we calculate and analyze the dynamics of artificial biotin and streptovidin variant using molecular dynamics simulation and free energy calculation to provide useful information which can not be captured by experiment.