Evidence for osteocyte regulation of bone homeostasis through RANKL expression.

Imamura K, Imamachi N, Akizuki G, Kumakura M, Kawaguchi A, Nagata K, Kato A, Kawaguchi Y, Sato H, Yoneda M, Kai C, Yada T, Suzuki Y, Yamada T, Ozawa T, Kaneki K, Inoue T, Kobayashi M, Kodama T, Wada Y, Sekimizu K, Akimitsu N. Evidence for osteocyte regulation of bone homeostasis through RANKL expression. Mol Cell. 2014 Feb 6;53(3):393-406. doi: 10.1016/j.molcel.2014.01.009. Erratum in: Mol Cell. 2014 Jun 19;54(6):1055.

Ets family members induce lymphangiogenesis through physical and functional interaction with Prox1.

Yuhashi K, Ohnishi S, Kodama T, Koike K, Kanamori H. Ets family members induce lymphangiogenesis through physical and functional interaction with Prox1. Virology. 2014 Feb;450-451:13-23. doi: 10.1016/j.virol.2013.11.036. Epub 2013 Dec 18.

The role of the BH3-only protein Noxa in bone homeostasis.

Fruchart JC, Davignon J, Hermans MP, Al-Rubeaan K, Amarenco P, Assmann G, Barter P, Betteridge J, Bruckert E, Cuevas A, Farnier M, Ferrannini E, Fioretto P, Genest J, Ginsberg HN, Gotto AM Jr, Hu D, Kadowaki T, Kodama T, Krempf M, Matsuzawa Y, N̼̱ez-Cort̩s JM, et al. The role of the BH3-only protein Noxa in bone homeostasis. Cardiovasc Diabetol. 2014 Jan 24;13:26. doi: 10.1186/1475-2840-13-26. Review.

Associations of plasma pentraxin 3 and monocyte chemoattractant protein-1 concentrations with cardiovascular disease in patients with chronic kidney disease.

Komatsu N, Okamoto K, Sawa S, Nakashima T, Oh-hora M, Kodama T, Tanaka S, Bluestone JA, Takayanagi H. Associations of plasma pentraxin 3 and monocyte chemoattractant protein-1 concentrations with cardiovascular disease in patients with chronic kidney disease. Nat Med. 2014 Jan;20(1):62-8. doi: 10.1038/nm.3432. Epub 2013 Dec 22.

Pathophysiological response to hypoxia – from the molecular mechanisms of malady to drug discovery: epigenetic regulation of the hypoxic response via hypoxia-inducible factor and histone modifying enzymes.

Lee YH, Iijima M, Kado Y, Mizohata E, Inoue T, Sugiyama A, Doi H, Shibasaki Y, Kodama T. Pathophysiological response to hypoxia – from the molecular mechanisms of malady to drug discovery: epigenetic regulation of the hypoxic response via hypoxia-inducible factor and histone modifying enzymes. Biochem Biophys Res Commun. 2013 Nov 29;441(4):1011-7. doi: 10.1016/j.bbrc.2013.11.014. Epub 2013 Nov 12.

A major role for RCAN1 in atherosclerosis progression.

Mendez-Barbero N, Esteban V, Villahoz S, Escolano A, Urso K, Alfranca A, Rodriguez C, Sanchez SA, Osawa T, Andres V, Martinez-Gonzalez J, Minami T, Redondo JM, Campanero MR. A major role for RCAN1 in atherosclerosis progression. EMBO Mol Med. 2013 Dec;5(12):1901-17. doi: 10.1002/emmm.201302842. Epub 2013 Oct 15.

Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle.

Horiuchi K, Kawamura T, Iwanari H, Ohashi R, Naito M, Kodama T, Hamakubo T. Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle. J Biol Chem. 2013 Nov 15;288(46):33292-302. doi: 10.1074/jbc.M113.500397. Epub 2013 Oct 7.

BMP4/Thrombospondin-1 loop paracrinically inhibits tumor angiogenesis and suppresses the growth of solid tumors.

Tsuchida R, Osawa T, Wang F, Nishii R, Das B, Tsuchida S, Muramatsu M, Takahashi T, Inoue T, Wada Y, Minami T, Yuasa Y, Shibuya M. BMP4/Thrombospondin-1 loop paracrinically inhibits tumor angiogenesis and suppresses the growth of solid tumors. Oncogene. 2014 Jul 17;33(29):3803-11. doi: 10.1038/onc.2013.358. Epub 2013 Sep 9.

Docking protein Gab1 is an essential component of postnatal angiogenesis after ischemia via HGF/c-met signaling.

Mimura I, Kanki Y, Kodama T, Nangaku M. Docking protein Gab1 is an essential component of postnatal angiogenesis after ischemia via HGF/c-met signaling. Kidney Int. 2014 Jan;85(1):31-8. doi: 10.1038/ki.2013.321. Epub 2013 Aug 28. Review.

The calcineurin-NFAT-angiopoietin-2 signaling axis in lung endothelium is critical for the establishment of lung metastases.

Minami T, Jiang S, Schadler K, Suehiro J, Osawa T, Oike Y, Miura M, Naito M, Kodama T, Ryeom S. The calcineurin-NFAT-angiopoietin-2 signaling axis in lung endothelium is critical for the establishment of lung metastases. Cell Rep. 2013 Aug 29;4(4):709-23. doi: 10.1016/j.celrep.2013.07.021. Epub 2013 Aug 15.

Maf promotes osteoblast differentiation in mice by mediating the age-related switch in mesenchymal cell differentiation.

Suzuki M, Kobayashi-Osaki M, Tsutsumi S, Pan X, Ohmori S, Takai J, Moriguchi T, Ohneda O, Ohneda K, Shimizu R, Kanki Y, Kodama T, Aburatani H, Yamamoto M. Maf promotes osteoblast differentiation in mice by mediating the age-related switch in mesenchymal cell differentiation. Genes Cells. 2013 Nov;18(11):921-33. doi: 10.1111/gtc.12086. Epub 2013 Aug 1.

Targeting cancer cells resistant to hypoxia and nutrient starvation to improve anti-angiogeneic therapy.

Osawa T, Shibuya M. Targeting cancer cells resistant to hypoxia and nutrient starvation to improve anti-angiogeneic therapy. Cell Cycle. 2013 Aug 15;12(16):2519-20. doi: 10.4161/cc.25729. Epub 2013 Jul 29. No abstract available.

Active RNA polymerases: mobile or immobile molecular machines?

Tachibana K, Takeuchi K, Inada H, Sugimoto K, Ishimoto K, Yamashita M, Maegawa T, Yamasaki D, Osada S, Tanaka T, Rakugi H, Hamakubo T, Sakai J, Kodama T, Doi T. Active RNA polymerases: mobile or immobile molecular machines? J Biochem. 2013 Sep;154(3):265-73. doi: 10.1093/jb/mvt050. Epub 2013 May 27.

Human mannose-binding lectin 2 is directly regulated by peroxisome proliferator-activated receptors via a peroxisome proliferator responsive element.

Tachibana K, Takeuchi K, Inada H, Sugimoto K, Ishimoto K, Yamashita M, Maegawa T, Yamasaki D, Osada S, Tanaka T, Rakugi H, Hamakubo T, Sakai J, Kodama T, Doi T. Human mannose-binding lectin 2 is directly regulated by peroxisome proliferator-activated receptors via a peroxisome proliferator responsive element. J Biochem. 2013 Sep;154(3):265-73. doi: 10.1093/jb/mvt050. Epub 2013 May 27.

Ly49Q, an ITIM-bearing NK receptor, positively regulates osteoclast differentiation.

Shoji K, Murayama T, Mimura I, Wada T, Kume H, Goto A, Ohse T, Tanaka T, Inagi R, van der Hoorn FA, Manabe I, Homma Y, Fukayama M, Sakurai T, Hasegawa T, Aburatani H, Kodama T, Nangaku M. Ly49Q, an ITIM-bearing NK receptor, positively regulates osteoclast differentiation. Am J Pathol. 2013 Jun;182(6):2191-203. doi: 10.1016/j.ajpath.2013.02.024. Epub 2013 Apr 17.

Inhibition of histone demethylase JMJD1A improves anti-angiogenic therapy and reduces tumor-associated macrophages.

Osawa T, Tsuchida R, Muramatsu M, Shimamura T, Wang F, Suehiro J, Kanki Y, Wada Y, Yuasa Y, Aburatani H, Miyano S, Minami T, Kodama T, Shibuya M. Inhibition of histone demethylase JMJD1A improves anti-angiogenic therapy and reduces tumor-associated macrophages. Cancer Res. 2013 May 15;73(10):3019-28. doi: 10.1158/0008-5472.CAN-12-3231. Epub 2013 Mar 14.