A method of generating antibodies against exogenously administered self-antigen by manipulating CD4+CD25+ regulatory T cells.

Iwanari H, Nakada-Nakura Y, Kusano-Arai O, Suzuki N, Kodama T, Sakihama T, Hamakubo T. A method of generating antibodies against exogenously administered self-antigen by manipulating CD4+CD25+ regulatory T cells. J Immunol Methods. 2011 Jun 30;369(1-2):108-14. doi: 10.1016/j.jim.2011.04.011. Epub 2011 May 3.

Visual observation of avidin-biotin affinity by fluorescent G4.5 poly(amidoamine) dendrimer.

Saravanan G, Daigo K, Imae T, Hamakubo T. Visual observation of avidin-biotin affinity by fluorescent G4.5 poly(amidoamine) dendrimer. Colloids Surf B Biointerfaces. 2011 Mar;83(1):58-60. doi: 10.1016/j.colsurfb.2010.10.043. Epub 2010 Nov 2.

Elevation of oxidized DJ-1 in the brain and erythrocytes of Parkinson disease model animals.

Akazawa YO, Saito Y, Hamakubo T, Masuo Y, Yoshida Y, Nishio K, Shichiri M, Miyasaka T, Iwanari H, Mochizuki Y, Kodama T, Noguchi N, Niki E. Elevation of oxidized DJ-1 in the brain and erythrocytes of Parkinson disease model animals. Neurosci Lett. 2010 Oct 15;483(3):201-5. doi: 10.1016/j.neulet.2010.08.007. Epub 2010 Aug 11.

Neural RNA-binding protein Musashi1 controls midline crossing of precerebellar neurons through posttranscriptional regulation of Robo3/Rig-1 expression.

Kuwako K, Kakumoto K, Imai T, Igarashi M, Hamakubo T, Sakakibara S, Tessier-Lavigne M, Okano HJ, Okano H. Neural RNA-binding protein Musashi1 controls midline crossing of precerebellar neurons through posttranscriptional regulation of Robo3/Rig-1 expression. Neuron. 2010 Aug 12;67(3):407-21. doi: 10.1016/j.neuron.2010.07.005.

A claudin-4 modulator enhances the mucosal absorption of a biologically active peptide.

Uchida H, Kondoh M, Hanada T, Takahashi A, Hamakubo T, Yagi K. A claudin-4 modulator enhances the mucosal absorption of a biologically active peptide. Biochem Pharmacol. 2010 May 15;79(10):1437-44. doi: 10.1016/j.bcp.2010.01.010. Epub 2010 Jan 21.

Preparation and application of monoclonal antibodies against oxidized DJ-1. Significant elevation of oxidized DJ-1 in erythrocytes of early-stage Parkinson disease patients.

Saito Y, Hamakubo T, Yoshida Y, Ogawa Y, Hara Y, Fujimura H, Imai Y, Iwanari H, Mochizuki Y, Shichiri M, Nishio K, Kinumi T, Noguchi N, Kodama T, Niki E. Preparation and application of monoclonal antibodies against oxidized DJ-1. Significant elevation of oxidized DJ-1 in erythrocytes of early-stage Parkinson disease patients. Neurosci Lett. 2009 Nov 6;465(1):1-5. doi: 10.1016/j.neulet.2009.08.074. Epub 2009 Sep 3.

Single chain variable fragment against nicastrin inhibits the gamma-secretase activity.

Hayashi I, Takatori S, Urano Y, Iwanari H, Isoo N, Osawa S, Fukuda MA, Kodama T, Hamakubo T, Li T, Wong PC, Tomita T, Iwatsubo T. Single chain variable fragment against nicastrin inhibits the gamma-secretase activity. J Biol Chem. 2009 Oct 9;284(41):27838-47. doi: 10.1074/jbc.M109.055061. Epub 2009 Aug 14.

A novel tumor-targeted therapy using a claudin-4-targeting molecule.

Saeki R, Kondoh M, Kakutani H, Tsunoda S, Mochizuki Y, Hamakubo T, Tsutsumi Y, Horiguchi Y, Yagi K. A novel tumor-targeted therapy using a claudin-4-targeting molecule. Mol Pharmacol. 2009 Oct;76(4):918-26. doi: 10.1124/mol.109.058412. Epub 2009 Jul 28.

The Down syndrome critical region gene 1 short variant promoters direct vascular bed-specific gene expression during inflammation in mice.

Minami T, Yano K, Miura M, Kobayashi M, Suehiro J, Reid PC, Hamakubo T, Ryeom S, Aird WC, Kodama T. The Down syndrome critical region gene 1 short variant promoters direct vascular bed-specific gene expression during inflammation in mice. J Clin Invest. 2009 Aug;119(8):2257-70. doi: 10.1172/JCI35738. Epub 2009 Jul 13.

Expression of the mouse PR domain protein Prdm8 in the developing central nervous system.

Komai T, Iwanari H, Mochizuki Y, Hamakubo T, Shinkai Y. Expression of the mouse PR domain protein Prdm8 in the developing central nervous system. Gene Expr Patterns. 2009 Oct;9(7):503-14. doi: 10.1016/j.gep.2009.07.005. Epub 2009 Jul 16.

Mobile DHHC palmitoylating enzyme mediates activity-sensitive synaptic targeting of PSD-95.

Noritake J, Fukata Y, Iwanaga T, Hosomi N, Tsutsumi R, Matsuda N, Tani H, Iwanari H, Mochizuki Y, Kodama T, Matsuura Y, Bredt DS, Hamakubo T, Fukata M. Mobile DHHC palmitoylating enzyme mediates activity-sensitive synaptic targeting of PSD-95. J Cell Biol. 2009 Jul 13;186(1):147-60. doi: 10.1083/jcb.200903101.

Prominent expression of FRS2beta protein in neural cells and its association with intracellular vesicles.

Minegishi Y, Iwanari H, Mochizuki Y, Horii T, Hoshino T, Kodama T, Hamakubo T, Gotoh N. Prominent expression of FRS2beta protein in neural cells and its association with intracellular vesicles. FEBS Lett. 2009 Feb 18;583(4):807-14. doi: 10.1016/j.febslet.2009.01.042. Epub 2009 Jan 31.

Angiopoietin-1 induces Kruppel-like factor 2 expression through a phosphoinositide 3-kinase/AKT-dependent activation of myocyte enhancer factor 2.

Sako K, Fukuhara S, Minami T, Hamakubo T, Song H, Kodama T, Fukamizu A, Gutkind JS, Koh GY, Mochizuki N. Angiopoietin-1 induces Kruppel-like factor 2 expression through a phosphoinositide 3-kinase/AKT-dependent activation of myocyte enhancer factor 2. J Biol Chem. 2009 Feb 27;284(9):5592-601. doi: 10.1074/jbc.M806928200. Epub 2008 Dec 23.

A simple detection method for low-affinity membrane protein interactions by baculoviral display.

Sakihama T, Sato T, Iwanari H, Kitamura T, Sakaguchi S, Kodama T, Hamakubo T. A simple detection method for low-affinity membrane protein interactions by baculoviral display. PLoS One. 2008;3(12):e4024. doi: 10.1371/journal.pone.0004024. Epub 2008 Dec 24.

Molecular diversity of TEX101, a marker glycoprotein for germ cells monitored with monoclonal antibodies: variety of the molecular characteristics according to subcellular localization within the mouse testis.

Yoshitake H, Shirai Y, Mochizuki Y, Iwanari H, Tsubamoto H, Koyama K, Takamori K, Ogawa H, Hasegawa A, Kodama T, Hamakubo T, Araki Y. Molecular diversity of TEX101, a marker glycoprotein for germ cells monitored with monoclonal antibodies: variety of the molecular characteristics according to subcellular localization within the mouse testis. J Reprod Immunol. 2008 Oct;79(1):1-11. doi: 10.1016/j.jri.2008.05.001. Epub 2008 Jul 11.

Functional reconstitution of G-protein-coupled receptor-mediated adenylyl cyclase activation by a baculoviral co-display system.

Sakihama T, Masuda K, Sato T, Doi T, Kodama T, Hamakubo T. Functional reconstitution of G-protein-coupled receptor-mediated adenylyl cyclase activation by a baculoviral co-display system. J Biotechnol. 2008 May 20;135(1):28-33. doi: 10.1016/j.jbiotec.2008.02.022. Epub 2008 Mar 7.