ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif.

Morikawa M, Koinuma D, Tsutsumi S, Vasilaki E, Kanki Y, Heldin CH, Aburatani H, Miyazono K. ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif. Nucleic Acids Res. 2011 Nov 1;39(20):8712-27. doi: 10.1093/nar/gkr572. Epub 2011 Jul 15.

Homozygously deleted gene DACH1 regulates tumor-initiating activity of glioma cells.

Watanabe A, Ogiwara H, Ehata S, Mukasa A, Ishikawa S, Maeda D, Ueki K, Ino Y, Todo T, Yamada Y, Fukayama M, Saito N, Miyazono K, Aburatani H. Homozygously deleted gene DACH1 regulates tumor-initiating activity of glioma cells. Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12384-9. doi: 10.1073/pnas.0906930108. Epub 2011 Jul 12.

ASCL1-coexpression profiling but not single gene expression profiling defines lung adenocarcinomas of neuroendocrine nature with poor prognosis.

Fujiwara T, Hiramatsu M, Isagawa T, Ninomiya H, Inamura K, Ishikawa S, Ushijima M, Matsuura M, Jones MH, Shimane M, Nomura H, Ishikawa Y, Aburatani H. ASCL1-coexpression profiling but not single gene expression profiling defines lung adenocarcinomas of neuroendocrine nature with poor prognosis. Lung Cancer. 2012 Jan;75(1):119-25. doi: 10.1016/j.lungcan.2011.05.028. Epub 2011 Jul 6.

Epigenetic regulation of osteoclast differentiation: possible involvement of Jmjd3 in the histone demethylation of Nfatc1.

Yasui T, Hirose J, Tsutsumi S, Nakamura K, Aburatani H, Tanaka S. Epigenetic regulation of osteoclast differentiation: possible involvement of Jmjd3 in the histone demethylation of Nfatc1. J Bone Miner Res. 2011 Nov;26(11):2665-71. doi: 10.1002/jbmr.464.

Gene expression profiling of mouse growth plate cartilage by laser microdissection and microarray analysis.

Isshiki H, Sato K, Horiuchi K, Tsutsumi S, Kano M, Ikegami H, Abe H, Umezawa A, Aburatani H, Toyama Y. Gene expression profiling of mouse growth plate cartilage by laser microdissection and microarray analysis. J Orthop Sci. 2011 Sep;16(5):670-2. doi: 10.1007/s00776-011-0119-2. Epub 2011 Jul 1. No abstract available.

Pathological role of osteoclast costimulation in arthritis-induced bone loss.

Idrus E, Nakashima T, Wang L, Hayashi M, Okamoto K, Kodama T, Tanaka N, Taniguchi T, Takayanagi H. Pathological role of osteoclast costimulation in arthritis-induced bone loss. Biochem Biophys Res Commun. 2011 Jul 8;410(3):620-5. doi: 10.1016/j.bbrc.2011.06.040. Epub 2011 Jun 13.

Gab family proteins are essential for postnatal maintenance of cardiac function via neuregulin-1/ErbB signaling.

Kanki Y, Kohro T, Jiang S, Tsutsumi S, Mimura I, Suehiro J, Wada Y, Ohta Y, Ihara S, Iwanari H, Naito M, Hamakubo T, Aburatani H, Kodama T, Minami T. Gab family proteins are essential for postnatal maintenance of cardiac function via neuregulin-1/ErbB signaling. EMBO J. 2011 Jun 10;30(13):2582-95. doi: 10.1038/emboj.2011.173.

Epigenetically coordinated GATA2 binding is necessary for endothelium-specific endomucin expression.

Kanki Y, Kohro T, Jiang S, Tsutsumi S, Mimura I, Suehiro J, Wada Y, Ohta Y, Ihara S, Iwanari H, Naito M, Hamakubo T, Aburatani H, Kodama T, Minami T. Epigenetically coordinated GATA2 binding is necessary for endothelium-specific endomucin expression. EMBO J. 2011 Jun 10;30(13):2582-95. doi: 10.1038/emboj.2011.173.

Cell type-specific target selection by combinatorial binding of Smad2/3 proteins and hepatocyte nuclear factor 4alpha in HepG2 cells.

Mizutani A, Koinuma D, Tsutsumi S, Kamimura N, Morikawa M, Suzuki HI, Imamura T, Miyazono K, Aburatani H. Cell type-specific target selection by combinatorial binding of Smad2/3 proteins and hepatocyte nuclear factor 4alpha in HepG2 cells. J Biol Chem. 2011 Aug 26;286(34):29848-60. doi: 10.1074/jbc.M110.217745. Epub 2011 Jun 6.

Methylation screening of reciprocal genome-wide UPDs identifies novel human-specific imprinted genes.

Nakabayashi K, Trujillo AM, Tayama C, Camprubi C, Yoshida W, Lapunzina P, Sanchez A, Soejima H, Aburatani H, Nagae G, Ogata T, Hata K, Monk D. Methylation screening of reciprocal genome-wide UPDs identifies novel human-specific imprinted genes. Hum Mol Genet. 2011 Aug 15;20(16):3188-97. doi: 10.1093/hmg/ddr224. Epub 2011 May 18.

Targeted deletion of class A macrophage scavenger receptor increases the risk of cardiac rupture after experimental myocardial infarction.

Iwanari H, Nakada-Nakura Y, Kusano-Arai O, Suzuki N, Kodama T, Sakihama T, Hamakubo T. Targeted deletion of class A macrophage scavenger receptor increases the risk of cardiac rupture after experimental myocardial infarction. J Immunol Methods. 2011 Jun 30;369(1-2):108-14. doi: 10.1016/j.jim.2011.04.011. Epub 2011 May 3.

A method of generating antibodies against exogenously administered self-antigen by manipulating CD4+CD25+ regulatory T cells.

Iwanari H, Nakada-Nakura Y, Kusano-Arai O, Suzuki N, Kodama T, Sakihama T, Hamakubo T. A method of generating antibodies against exogenously administered self-antigen by manipulating CD4+CD25+ regulatory T cells. J Immunol Methods. 2011 Jun 30;369(1-2):108-14. doi: 10.1016/j.jim.2011.04.011. Epub 2011 May 3.

Tumor suppressor miR-22 determines p53-dependent cellular fate through post-transcriptional regulation of p21.

Tsuchiya N, Izumiya M, Ogata-Kawata H, Okamoto K, Fujiwara Y, Nakai M, Okabe A, Schetter AJ, Bowman ED, Midorikawa Y, Sugiyama Y, Aburatani H, Harris CC, Nakagama H. Tumor suppressor miR-22 determines p53-dependent cellular fate through post-transcriptional regulation of p21. Cancer Res. 2011 Jul 1;71(13):4628-39. doi: 10.1158/0008-5472.CAN-10-2475. Epub 2011 May 12.

Macrophage scavenger receptor-a-deficient mice are resistant against diabetic nephropathy through amelioration of microinflammation.

Nishi K, Imamura T, Kitamura K, Ogawa T, Fujimoto S, Kakitsubata Y, Ishikawa T, Asada Y, Kodama T. Macrophage scavenger receptor-a-deficient mice are resistant against diabetic nephropathy through amelioration of microinflammation. Ren Fail. 2011;33(4):398-404. doi: 10.3109/0886022X.2011.568136.

Influence of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on ubiquinone levels in rat skeletal muscle and heart: relationship to cytotoxicity and inhibitory activity for cholesterol synthesis in human skeletal muscle cells.

Yamasaki D, Kawabe N, Nakamura H, Tachibana K, Ishimoto K, Tanaka T, Aburatani H, Sakai J, Hamakubo T, Kodama T, Doi T. Influence of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on ubiquinone levels in rat skeletal muscle and heart: relationship to cytotoxicity and inhibitory activity for cholesterol synthesis in human skeletal muscle cells. Eur J Cell Biol. 2011 Aug;90(8):657-64. doi: 10.1016/j.ejcb.2011.02.005. Epub 2011 Apr 21.

Tissue-specific demethylation in CpG-poor promoters during cellular differentiation.

Nagae G, Isagawa T, Shiraki N, Fujita T, Yamamoto S, Tsutsumi S, Nonaka A, Yoshiba S, Matsusaka K, Midorikawa Y, Ishikawa S, Soejima H, Fukayama M, Suemori H, Nakatsuji N, Kume S, Aburatani H. Tissue-specific demethylation in CpG-poor promoters during cellular differentiation. Hum Mol Genet. 2011 Jul 15;20(14):2710-21. doi: 10.1093/hmg/ddr170. Epub 2011 Apr 19.