Clinical significance of steroid and xenobiotic receptor and its targeted gene CYP3A4 in human prostate cancer.

Fujimura T, Takahashi S, Urano T, Tanaka T, Zhang W, Azuma K, Takayama K, Obinata D, Murata T, Horie-Inoue K, Kodama T, Ouchi Y, Homma Y, Inoue S. Clinical significance of steroid and xenobiotic receptor and its targeted gene CYP3A4 in human prostate cancer. Cancer Sci. 2012 Feb;103(2):176-80. doi: 10.1111/j.1349-7006.2011.02143.x. Epub 2011 Nov 27.

Proteomic analysis of native hepatocyte nuclear factor-4α (HNF4α) isoforms, phosphorylation status, and interactive cofactors.

Daigo K, Kawamura T, Ohta Y, Ohashi R, Katayose S, Tanaka T, Aburatani H, Naito M, Kodama T, Ihara S, Hamakubo T. Proteomic analysis of native hepatocyte nuclear factor-4α (HNF4α) isoforms, phosphorylation status, and interactive cofactors. J Biol Chem. 2011 Jan 7;286(1):674-86. doi: 10.1074/jbc.M110.154732. Epub 2010 Nov 3. Erratum in: J Biol Chem. 2013 Aug 16;288(33):24161.

Fenofibrate suppresses growth of the human hepatocellular carcinoma cell via PPARα-independent mechanisms.

Yamasaki D, Kawabe N, Nakamura H, Tachibana K, Ishimoto K, Tanaka T, Aburatani H, Sakai J, Hamakubo T, Kodama T, Doi T. Fenofibrate suppresses growth of the human hepatocellular carcinoma cell via PPARα-independent mechanisms. Eur J Cell Biol. 2011 Aug;90(8):657-64. doi: 10.1016/j.ejcb.2011.02.005. Epub 2011 Apr 21.

Therapeutic role of rifaximin in inflammatory bowel disease: clinical implication of human pregnane X receptor activation.

Cheng J, Shah YM, Ma X, Pang X, Tanaka T, Kodama T, Krausz KW, Gonzalez FJ. Therapeutic role of rifaximin in inflammatory bowel disease: clinical implication of human pregnane X receptor activation. J Pharmacol Exp Ther. 2010 Oct;335(1):32-41. doi: 10.1124/jpet.110.170225. Epub 2010 Jul 13.

Role of histone methylation and demethylation in adipogenesis and obesity.

Okamura M, Inagaki T, Tanaka T, Sakai J. Role of histone methylation and demethylation in adipogenesis and obesity. Organogenesis. 2010 Jan-Mar;6(1):24-32. Review.

[Recent trends in PPARgamma agonist development of thiazolidinediones and non-thiazolidinediones].

Tanaka T. [Recent trends in PPARgamma agonist development of thiazolidinediones and non-thiazolidinediones]. Nihon Rinsho. 2010 Feb;68(2):249-55. Review. Japanese.

Regulation of the human SLC25A20 expression by peroxisome proliferator-activated receptor alpha in human hepatoblastoma cells.

Tachibana K, Takeuchi K, Inada H, Yamasaki D, Ishimoto K, Tanaka T, Hamakubo T, Sakai J, Kodama T, Doi T. Regulation of the human SLC25A20 expression by peroxisome proliferator-activated receptor alpha in human hepatoblastoma cells. Biochem Biophys Res Commun. 2009 Nov 20;389(3):501-5. doi: 10.1016/j.bbrc.2009.09.018. Epub 2009 Sep 11.

Obesity and metabolic syndrome in histone demethylase JHDM2a-deficient mice.

Inagaki T, Tachibana M, Magoori K, Kudo H, Tanaka T, Okamura M, Naito M, Kodama T, Shinkai Y, Sakai J. Obesity and metabolic syndrome in histone demethylase JHDM2a-deficient mice. Genes Cells. 2009 Aug;14(8):991-1001. doi: 10.1111/j.1365-2443.2009.01326.x. Epub 2009 Jul 15.

Immunohistochemical staining for P1 and P2 promoter-driven hepatocyte nuclear factor-4alpha may complement mucin phenotype of differentiated-type early gastric carcinoma.

Takano K, Hasegawa G, Jiang S, Kurosaki I, Hatakeyama K, Iwanari H, Tanaka T, Hamakubo T, Kodama T, Naito M. Immunohistochemical staining for P1 and P2 promoter-driven hepatocyte nuclear factor-4alpha may complement mucin phenotype of differentiated-type early gastric carcinoma. Pathol Int. 2009 Jul;59(7):462-70. doi: 10.1111/j.1440-1827.2009.02394.x.

Sterol-mediated regulation of human lipin 1 gene expression in hepatoblastoma cells.

Ishimoto K, Nakamura H, Tachibana K, Yamasaki D, Ota A, Hirano K, Tanaka T, Hamakubo T, Sakai J, Kodama T, Doi T. Sterol-mediated regulation of human lipin 1 gene expression in hepatoblastoma cells. J Biol Chem. 2009 Aug 14;284(33):22195-205. doi: 10.1074/jbc.M109.028753. Epub 2009 Jun 24.

The peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha heterodimer targets the histone modification enzyme PR-Set7/Setd8 gene and regulates adipogenesis through a positive feedback loop.

Wakabayashi K, Okamura M, Tsutsumi S, Nishikawa NS, Tanaka T, Sakakibara I, Kitakami J, Ihara S, Hashimoto Y, Hamakubo T, Kodama T, Aburatani H, Sakai J. The peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha heterodimer targets the histone modification enzyme PR-Set7/Setd8 gene and regulates adipogenesis through a positive feedback loop. Mol Cell Biol. 2009 Jul;29(13):3544-55. doi: 10.1128/MCB.01856-08. Epub 2009 May 4.

COUP-TFII acts downstream of Wnt/beta-catenin signal to silence PPARgamma gene expression and repress adipogenesis.

Okamura M, Kudo H, Wakabayashi K, Tanaka T, Nonaka A, Uchida A, Tsutsumi S, Sakakibara I, Naito M, Osborne TF, Hamakubo T, Ito S, Aburatani H, Yanagisawa M, Kodama T, Sakai J. COUP-TFII acts downstream of Wnt/beta-catenin signal to silence PPARgamma gene expression and repress adipogenesis. Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5819-24. doi: 10.1073/pnas.0901676106. Epub 2009 Mar 23.

Expression of liver X receptor alpha and lipid metabolism in granulocyte-macrophage colony-stimulating factor-induced human monocyte-derived macrophage.

Kazawa T, Kawasaki T, Sakamoto A, Imamura M, Ohashi R, Jiang S, Tanaka T, Iwanari H, Hamakubo T, Sakai J, Kodama T, Naito M. Expression of liver X receptor alpha and lipid metabolism in granulocyte-macrophage colony-stimulating factor-induced human monocyte-derived macrophage. Pathol Int. 2009 Mar;59(3):152-60. doi: 10.1111/j.1440-1827.2009.02343.x.

Fasting-induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 2.

Sakakibara I, Fujino T, Ishii M, Tanaka T, Shimosawa T, Miura S, Zhang W, Tokutake Y, Yamamoto J, Awano M, Iwasaki S, Motoike T, Okamura M, Inagaki T, Kita K, Ezaki O, Naito M, Kuwaki T, Chohnan S, Yamamoto TT, Hammer RE, Kodama T, et al. Fasting-induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 2. Cell Metab. 2009 Feb;9(2):191-202. doi: 10.1016/j.cmet.2008.12.008.

Protein expression of nuclear receptors in human and murine tissues.

Takegoshi S, Jiang S, Ohashi R, Savchenko AS, Iwanari H, Tanaka T, Hasegawa G, Hamakubo T, Kodama T, Naito M. Protein expression of nuclear receptors in human and murine tissues. Pathol Int. 2009 Feb;59(2):61-72. doi: 10.1111/j.1440-1827.2008.02330.x.

Regulation of the human PDZK1 expression by peroxisome proliferator-activated receptor alpha.

Tachibana K, Anzai N, Ueda C, Katayama T, Yamasaki D, Kirino T, Takahashi R, Ishimoto K, Komori H, Tanaka T, Hamakubo T, Ueda Y, Arai H, Sakai J, Kodama T, Doi T. Regulation of the human PDZK1 expression by peroxisome proliferator-activated receptor alpha. FEBS Lett. 2008 Nov 26;582(28):3884-8. doi: 10.1016/j.febslet.2008.10.027. Epub 2008 Oct 26.