Aberrant promoter methylation of PPP1R3C and EFHD1 in plasma of colorectal cancer patients.

Takane K, Midorikawa Y, Yagi K, Sakai A, Aburatani H, Takayama T, Kaneda A. Aberrant promoter methylation of PPP1R3C and EFHD1 in plasma of colorectal cancer patients. Cancer Med. 2014 Oct;3(5):1235-45. doi: 10.1002/cam4.273. Epub 2014 May 24.

Hes1 promotes blast crisis in chronic myelogenous leukemia through MMP-9 upregulation in leukemic cells.

Nakahara F, Kitaura J, Uchida T, Nishida C, Togami K, Inoue D, Matsukawa T, Kagiyama Y, Enomoto Y, Kawabata KC, Chen-Yi L, Komeno Y, Izawa K, Oki T, Nagae G, Harada Y, Harada H, Otsu M, Aburatani H, Heissig B, Hattori K, Kitamura T. Hes1 promotes blast crisis in chronic myelogenous leukemia through MMP-9 upregulation in leukemic cells. Blood. 2014 Jun 19;123(25):3932-42. doi: 10.1182/blood-2013-01-476747. Epub 2014 May 13.

Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma.

Kakiuchi M, Nishizawa T, Ueda H, Gotoh K, Tanaka A, Hayashi A, Yamamoto S, Tatsuno K, Katoh H, Watanabe Y, Ichimura T, Ushiku T, Funahashi S, Tateishi K, Wada I, Shimizu N, Nomura S, Koike K, Seto Y, Fukayama M, Aburatani H, Ishikawa S. Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma. Nat Genet. 2014 Jun;46(6):583-7. doi: 10.1038/ng.2984. Epub 2014 May 11.

Severe dermatitis with loss of epidermal Langerhans cells in human and mouse zinc deficiency.

Maejima T, Inoue T, Kanki Y, Kohro T, Li G, Ohta Y, Kimura H, Kobayashi M, Taguchi A, Tsutsumi S, Iwanari H, Yamamoto S, Aruga H, Dong S, Stevens JF, Poh HM, Yamamoto K, Kawamura T, Mimura I, Suehiro J, Sugiyama A, Kaneki K, et al. Severe dermatitis with loss of epidermal Langerhans cells in human and mouse zinc deficiency. PLoS One. 2014 May 5;9(5):e96005. doi: 10.1371/journal.pone.0096005. eCollection 2014. Erratum in: PLoS One. 2014;9(6):e99749.

Direct evidence for pitavastatin induced chromatin structure change in the KLF4 gene in endothelial cells.

Maejima T, Inoue T, Kanki Y, Kohro T, Li G, Ohta Y, Kimura H, Kobayashi M, Taguchi A, Tsutsumi S, Iwanari H, Yamamoto S, Aruga H, Dong S, Stevens JF, Poh HM, Yamamoto K, Kawamura T, Mimura I, Suehiro J, Sugiyama A, Kaneki K, et al. Direct evidence for pitavastatin induced chromatin structure change in the KLF4 gene in endothelial cells. PLoS One. 2014 May 5;9(5):e96005. doi: 10.1371/journal.pone.0096005. eCollection 2014. Erratum in: PLoS One. 2014;9(6):e99749.

Expression of PRMT5 in lung adenocarcinoma and its significance in epithelial-mesenchymal transition.

Ibrahim R, Matsubara D, Osman W, Morikawa T, Goto A, Morita S, Ishikawa S, Aburatani H, Takai D, Nakajima J, Fukayama M, Niki T, Murakami Y. Expression of PRMT5 in lung adenocarcinoma and its significance in epithelial-mesenchymal transition. Hum Pathol. 2014 Jul;45(7):1397-405. doi: 10.1016/j.humpath.2014.02.013. Epub 2014 Feb 28.

ROBO1, a tumor suppressor and critical molecular barrier for localized tumor cells to acquire invasive phenotype: study in African-American and Caucasian prostate cancer models.

Parray A, Siddique HR, Kuriger JK, Mishra SK, Rhim JS, Nelson HH, Aburatani H, Konety BR, Koochekpour S, Saleem M. ROBO1, a tumor suppressor and critical molecular barrier for localized tumor cells to acquire invasive phenotype: study in African-American and Caucasian prostate cancer models. Int J Cancer. 2014 Dec 1;135(11):2493-506. doi: 10.1002/ijc.28919. Epub 2014 Apr 29.

A subset of small cell lung cancer with low neuroendocrine expression and good prognosis: a comparison study of surgical and inoperable cases with biopsy.

Hamanaka W, Motoi N, Ishikawa S, Ushijima M, Inamura K, Hatano S, Uehara H, Okumura S, Nakagawa K, Nishio M, Horai T, Aburatani H, Matsuura M, Iwasaki A, Ishikawa Y. A subset of small cell lung cancer with low neuroendocrine expression and good prognosis: a comparison study of surgical and inoperable cases with biopsy. Hum Pathol. 2014 May;45(5):1045-56. doi: 10.1016/j.humpath.2014.01.001. Epub 2014 Jan 23.

Methionine metabolism regulates maintenance and differentiation of human pluripotent stem cells.

Shiraki N, Shiraki Y, Tsuyama T, Obata F, Miura M, Nagae G, Aburatani H, Kume K, Endo F, Kume S. Methionine metabolism regulates maintenance and differentiation of human pluripotent stem cells. Cell Metab. 2014 May 6;19(5):780-94. doi: 10.1016/j.cmet.2014.03.017. Epub 2014 Apr 17.

Cellular-automaton model of the cooperative dynamics of RNA polymerase II during transcription in human cells.

Inoue T, Kohro T, Tanaka T, Kanki Y, Li G, Poh HM, Mimura I, Kobayashi M, Taguchi A, Maejima T, Suehiro J, Sugiyama A, Kaneki K, Aruga H, Dong S, Stevens JF, Yamamoto S, Tsutsumi S, Fujita T, Ruan X, Aburatani H, Nangaku M, et al. Cellular-automaton model of the cooperative dynamics of RNA polymerase II during transcription in human cells. Genome Biol. 2014 Apr 10;15(4):R63. doi: 10.1186/gb-2014-15-4-r63.

Cross-enhancement of ANGPTL4 transcription by HIF1 alpha and PPAR beta/delta is the result of the conformational proximity of two response elements.

Inoue T, Kohro T, Tanaka T, Kanki Y, Li G, Poh HM, Mimura I, Kobayashi M, Taguchi A, Maejima T, Suehiro J, Sugiyama A, Kaneki K, Aruga H, Dong S, Stevens JF, Yamamoto S, Tsutsumi S, Fujita T, Ruan X, Aburatani H, Nangaku M, et al. Cross-enhancement of ANGPTL4 transcription by HIF1 alpha and PPAR beta/delta is the result of the conformational proximity of two response elements. Genome Biol. 2014 Apr 10;15(4):R63. doi: 10.1186/gb-2014-15-4-r63.

Genome-wide analysis of the chromatin composition of histone H2A and H3 variants in mouse embryonic stem cells.

Yukawa M, Akiyama T, Franke V, Mise N, Isagawa T, Suzuki Y, Suzuki MG, Vlahovicek K, Abe K, Aburatani H, Aoki F. Genome-wide analysis of the chromatin composition of histone H2A and H3 variants in mouse embryonic stem cells. PLoS One. 2014 Mar 21;9(3):e92689. doi: 10.1371/journal.pone.0092689. eCollection 2014.

Conjugation-free, visual, and quantitative evaluation of inhibitors on protein tyrosine kinases and phosphatases with a luminescent Tb(III) complex.

Akiba H, Sumaoka J, Hamakubo T, Komiyama M. Conjugation-free, visual, and quantitative evaluation of inhibitors on protein tyrosine kinases and phosphatases with a luminescent Tb(III) complex. Anal Bioanal Chem. 2014 May;406(12):2957-64. doi: 10.1007/s00216-014-7707-x. Epub 2014 Mar 21.

Concurrent activation of acetylation and tri-methylation of H3K27 in a subset of hepatocellular carcinoma with aggressive behavior.

Hayashi A, Yamauchi N, Shibahara J, Kimura H, Morikawa T, Ishikawa S, Nagae G, Nishi A, Sakamoto Y, Kokudo N, Aburatani H, Fukayama M. Concurrent activation of acetylation and tri-methylation of H3K27 in a subset of hepatocellular carcinoma with aggressive behavior. PLoS One. 2014 Mar 10;9(3):e91330. doi: 10.1371/journal.pone.0091330. eCollection 2014.

Methylation epigenotypes and genetic features in colorectal laterally spreading tumors.

Sakai E, Ohata K, Chiba H, Matsuhashi N, Doi N, Fukushima J, Endo H, Takahashi H, Tsuji S, Yagi K, Matsusaka K, Aburatani H, Nakajima A, Kaneda A. Methylation epigenotypes and genetic features in colorectal laterally spreading tumors. Int J Cancer. 2014 Oct 1;135(7):1586-95. doi: 10.1002/ijc.28814. Epub 2014 Mar 10.

Suppression of bone formation by osteoclastic expression of semaphorin 4D.

Kudo S, Caaveiro JM, Goda S, Nagatoishi S, Ishii K, Matsuura T, Sudou Y, Kodama T, Hamakubo T, Tsumoto K. Suppression of bone formation by osteoclastic expression of semaphorin 4D. Biochemistry. 2014 Mar 25;53(11):1742-52. doi: 10.1021/bi401341g. Epub 2014 Mar 10.