Integrative Nutriomics and Oncology

Based on the conventional nutritional notion, carbohydrates, lipids and amino acids were independently considered in cancer. However, recent researches in cancer metabolism have been dramatically improved our metabolic knowledge of these disorders due to latest understanding of cancer metabolism. Indeed, carbohydrates, lipids and amino acids are inter-connected in the metabolic pathways, through the several key metabolic molecules such as acetyl-CoA and ketone body intermediates partly under epigenetic regulation. Our group reported that hypoxia, nutrient starvation, acidic pH may induce tumor aggressiveness by epigenetic regulation in cancer cells. We found that epigenetic and metabolic changes influence cancer progression, that can be utilizes for the development of novel therapies by integration of genome, epigenome, transcriptome, proteome, metabolome analysis.Our research objectives: (1)To identify novel onco-metabolites (cancer associated metabolites) for the treatment of cancer. (2)To understand the mechanism of cancer adaptation in carbohydrate/lipids/amino acids deficiency and apply it to therapy. (3)Latest understanding of “nutriomics” for treatment of cancer. We challenge to develop therapeutics for metastasis and recurrent advanced cancer through the viewpoint of integrative “multiomics” approach.
Osawa Laboratory

Project Associate Professor