The number of hypertensive and diabetic patients reaches 40 and 9.5 million in Japan. Despite the development of many anti-hypertensive and –diabetic drugs, the number of cardiovascular disease and chronic kidney disease keeps increasing. Epigenetic abnormalities may underlie hypertension and diabetic kidney disease. Epigenetics, a switching mechanism involved in regulation of gene expression by DNA methylation and histone modifications, controls memory of the cells. We are trying to find new diagnostic and therapeutic approaches by targeting epigenetic abnormalities.