The spiroketals containing a benzyloxymethyl moiety at C8 position showed the most potent apoptosis-inducing activity.

Shinya Mitsuhashi, Hiroshi Shima, Takeshi Kawamura, Kunimi Kikuchi, Masato Oikawa, Akitami Ichihara and Hideaki Oikawa. The spiroketals containing a benzyloxymethyl moiety at C8 position showed the most potent apoptosis-inducing activity. Biochemical & Medicinal Chemistry Letter 1999, 9: 2007-2012, PMID: 10450971