Human ROBO1 is cleaved by metalloproteinases and gamma-secretase and migrates to the nucleus in cancer cells.

Seki M, Watanabe A, Enomoto S, Kawamura T, Ito H, Kodama T, Hamakubo T, Aburatani H.FEBS Lett. 2010 Jul 02;584(13):2909-15. doi: 10.1016/j.febslet.2010.05.009