Genome-wide approaches reveal functional vascular endothelial growth factor (VEGF)-inducible nuclear factor of activated T cells (NFAT) c1 binding to angiogenesis-related genes in the endothelium.

Suehiro J, Kanki Y, Makihara C, Schadler K, Miura M, Manabe Y, Aburatani H, Kodama T, Minami T. Genome-wide approaches reveal functional vascular endothelial growth factor (VEGF)-inducible nuclear factor of activated T cells (NFAT) c1 binding to angiogenesis-related genes in the endothelium. J Biol Chem. 2014 Oct 17;289(42):29044-59. doi: 10.1074/jbc.M114.555235. Epub 2014 Aug 25.

Generation of antibodies against membrane proteins.

Hamakubo T, Kusano-Arai O, Iwanari H. Generation of antibodies against membrane proteins. Biochim Biophys Acta. 2014 Nov;1844(11):1920-1924. doi: 10.1016/j.bbapap.2014.08.007. Epub 2014 Aug 15. Review.

Potential biomarker for human uterine leiomyosarcoma.

Hayashi T, Horiuchi A, Aburatani H, Ishiko O, Yaegashi N, Kanai Y, Zharhary D, Shiozawa T, Tonegawa S, Konishi I. Potential biomarker for human uterine leiomyosarcoma. J Clin Med Res. 2014 Oct;6(5):392-4. doi: 10.14740/jocmr1867e. Epub 2014 Jul 28. No abstract available.

A Smad3 and TTF-1/NKX2-1 complex regulates Smad4-independent gene expression.

Isogaya K, Koinuma D, Tsutsumi S, Saito RA, Miyazawa K, Aburatani H, Miyazono K. A Smad3 and TTF-1/NKX2-1 complex regulates Smad4-independent gene expression. Cell Res. 2014 Aug;24(8):994-1008. doi: 10.1038/cr.2014.97. Epub 2014 Jul 25.

PPARβ/δ activation of CD300a controls intestinal immunity.

Tanaka T, Tahara-Hanaoka S, Nabekura T, Ikeda K, Jiang S, Tsutsumi S, Inagaki T, Magoori K, Higurashi T, Takahashi H, Tachibana K, Tsurutani Y, Raza S, Anai M, Minami T, Wada Y, Yokote K, Doi T, Hamakubo T, Auwerx J, Gonzalez FJ, Nakajima A, Aburatani H, Naito M, Shibuya A, Kodama T, Sakai J. PPARβ/δ activation of CD300a controls intestinal immunity. Sci Rep. 2014 Jun 24;4:5412. doi: 10.1038/srep05412.

Osteoprotection by semaphorin 3A.

Fujiwara K, Koyama K, Suga K, Ikemura M, Saito Y, Hino A, Iwanari H, Kusano-Arai O, Mitsui K, Kasahara H, Fukayama M, Kodama T, Hamakubo T, Momose T. Osteoprotection by semaphorin 3A. EJNMMI Res. 2014 Jun 1;4:29. doi: 10.1186/s13550-014-0029-3. eCollection 2014.

Vitamin E decreases bone mass by stimulating osteoclast fusion.

Yamashita T, Ueda A, Mitsui T, Tomonaga A, Matsumoto S, Kodama T, Fujitani H. Vitamin E decreases bone mass by stimulating osteoclast fusion. Chem Pharm Bull (Tokyo). 2014;62(7):661-7.

Molecular dynamics simulation-based evaluation of the binding free energies of computationally designed drug candidates: importance of the dynamical effects.

Yamashita T, Ueda A, Mitsui T, Tomonaga A, Matsumoto S, Kodama T, Fujitani H. Molecular dynamics simulation-based evaluation of the binding free energies of computationally designed drug candidates: importance of the dynamical effects. Chem Pharm Bull (Tokyo). 2014;62(7):661-7.

Pentraxin 3: a novel biomarker for inflammatory cardiovascular disease.

Tanaka T, Tahara-Hanaoka S, Nabekura T, Ikeda K, Jiang S, Tsutsumi S, Inagaki T, Magoori K, Higurashi T, Takahashi H, Tachibana K, Tsurutani Y, Raza S, Anai M, Minami T, Wada Y, Yokote K, Doi T, Hamakubo T, Auwerx J, Gonzalez FJ, Nakajima A, et al. Pentraxin 3: a novel biomarker for inflammatory cardiovascular disease. Sci Rep. 2014 Jun 24;4:5412. doi: 10.1038/srep05412.

On accurate calculation of the potential of mean force between antigen and antibody: A case of the HyHEL-10-hen egg white lysozyme system

T. Yamashita and H. Fujitani On accurate calculation of the potential of mean force between antigen and antibody: A case of the HyHEL-10-hen egg white lysozyme system Chem Phys Lett 2014, v. 609, pp. 50-53 https://doi.org/10.1016/j.cplett.2014.06.028

Immunostaining of oxidized DJ-1 in human and mouse brains.

Saito Y, Miyasaka T, Hatsuta H, Takahashi-Niki K, Hayashi K, Mita Y, Kusano-Arai O, Iwanari H, Ariga H, Hamakubo T, Yoshida Y, Niki E, Murayama S, Ihara Y, Noguchi N. Immunostaining of oxidized DJ-1 in human and mouse brains. J Neuropathol Exp Neurol. 2014 Jul;73(7):714-28. doi: 10.1097/NEN.0000000000000087.

Aberrant promoter methylation of PPP1R3C and EFHD1 in plasma of colorectal cancer patients.

Takane K, Midorikawa Y, Yagi K, Sakai A, Aburatani H, Takayama T, Kaneda A. Aberrant promoter methylation of PPP1R3C and EFHD1 in plasma of colorectal cancer patients. Cancer Med. 2014 Oct;3(5):1235-45. doi: 10.1002/cam4.273. Epub 2014 May 24.

Hes1 promotes blast crisis in chronic myelogenous leukemia through MMP-9 upregulation in leukemic cells.

Nakahara F, Kitaura J, Uchida T, Nishida C, Togami K, Inoue D, Matsukawa T, Kagiyama Y, Enomoto Y, Kawabata KC, Chen-Yi L, Komeno Y, Izawa K, Oki T, Nagae G, Harada Y, Harada H, Otsu M, Aburatani H, Heissig B, Hattori K, Kitamura T. Hes1 promotes blast crisis in chronic myelogenous leukemia through MMP-9 upregulation in leukemic cells. Blood. 2014 Jun 19;123(25):3932-42. doi: 10.1182/blood-2013-01-476747. Epub 2014 May 13.

Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma.

Kakiuchi M, Nishizawa T, Ueda H, Gotoh K, Tanaka A, Hayashi A, Yamamoto S, Tatsuno K, Katoh H, Watanabe Y, Ichimura T, Ushiku T, Funahashi S, Tateishi K, Wada I, Shimizu N, Nomura S, Koike K, Seto Y, Fukayama M, Aburatani H, Ishikawa S. Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma. Nat Genet. 2014 Jun;46(6):583-7. doi: 10.1038/ng.2984. Epub 2014 May 11.

Severe dermatitis with loss of epidermal Langerhans cells in human and mouse zinc deficiency.

Maejima T, Inoue T, Kanki Y, Kohro T, Li G, Ohta Y, Kimura H, Kobayashi M, Taguchi A, Tsutsumi S, Iwanari H, Yamamoto S, Aruga H, Dong S, Stevens JF, Poh HM, Yamamoto K, Kawamura T, Mimura I, Suehiro J, Sugiyama A, Kaneki K, et al. Severe dermatitis with loss of epidermal Langerhans cells in human and mouse zinc deficiency. PLoS One. 2014 May 5;9(5):e96005. doi: 10.1371/journal.pone.0096005. eCollection 2014. Erratum in: PLoS One. 2014;9(6):e99749.

Direct evidence for pitavastatin induced chromatin structure change in the KLF4 gene in endothelial cells.

Maejima T, Inoue T, Kanki Y, Kohro T, Li G, Ohta Y, Kimura H, Kobayashi M, Taguchi A, Tsutsumi S, Iwanari H, Yamamoto S, Aruga H, Dong S, Stevens JF, Poh HM, Yamamoto K, Kawamura T, Mimura I, Suehiro J, Sugiyama A, Kaneki K, et al. Direct evidence for pitavastatin induced chromatin structure change in the KLF4 gene in endothelial cells. PLoS One. 2014 May 5;9(5):e96005. doi: 10.1371/journal.pone.0096005. eCollection 2014. Erratum in: PLoS One. 2014;9(6):e99749.