Establishment of monoclonal antibodies against the extracellular domain that block binding of NMO-IgG to AQP4.

Miyazaki K, Abe Y, Iwanari H, Suzuki Y, Kikuchi T, Ito T, Kato J, Kusano-Arai O, Takahashi T, Nishiyama S, Ikeshima-Kataoka H, Tsuji S, Arimitsu T, Kato Y, Sakihama T, Toyama Y, Fujihara K, Hamakubo T, Yasui M. Establishment of monoclonal antibodies against the extracellular domain that block binding of NMO-IgG to AQP4. J Neuroimmunol. 2013 Jul 15;260(1-2):107-16. doi: 10.1016/j.jneuroim.2013.03.003.

EVI1 oncogene promotes KRAS pathway through suppression of microRNA-96 in pancreatic carcinogenesis.

Tanaka M, Suzuki HI, Shibahara J, Kunita A, Isagawa T, Yoshimi A, Kurokawa M, Miyazono K, Aburatani H, Ishikawa S, Fukayama M. EVI1 oncogene promotes KRAS pathway through suppression of microRNA-96 in pancreatic carcinogenesis. Oncogene. 2014 May 8;33(19):2454-63. doi: 10.1038/onc.2013.204. Epub 2013 Jun 10.

PRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small cell lung cancer.

Sato T, Kaneda A, Tsuji S, Isagawa T, Yamamoto S, Fujita T, Yamanaka R, Tanaka Y, Nukiwa T, Marquez VE, Ishikawa Y, Ichinose M, Aburatani H. PRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small cell lung cancer. Sci Rep. 2013;3:1911. doi: 10.1038/srep01911.

Active RNA polymerases: mobile or immobile molecular machines?

Tachibana K, Takeuchi K, Inada H, Sugimoto K, Ishimoto K, Yamashita M, Maegawa T, Yamasaki D, Osada S, Tanaka T, Rakugi H, Hamakubo T, Sakai J, Kodama T, Doi T. Active RNA polymerases: mobile or immobile molecular machines? J Biochem. 2013 Sep;154(3):265-73. doi: 10.1093/jb/mvt050. Epub 2013 May 27.

Human mannose-binding lectin 2 is directly regulated by peroxisome proliferator-activated receptors via a peroxisome proliferator responsive element.

Tachibana K, Takeuchi K, Inada H, Sugimoto K, Ishimoto K, Yamashita M, Maegawa T, Yamasaki D, Osada S, Tanaka T, Rakugi H, Hamakubo T, Sakai J, Kodama T, Doi T. Human mannose-binding lectin 2 is directly regulated by peroxisome proliferator-activated receptors via a peroxisome proliferator responsive element. J Biochem. 2013 Sep;154(3):265-73. doi: 10.1093/jb/mvt050. Epub 2013 May 27.

Histone demethylase KDM4C regulates sphere formation by mediating the cross talk between Wnt and Notch pathways in colonic cancer cells.

Yamamoto S, Tateishi K, Kudo Y, Yamamoto K, Isagawa T, Nagae G, Nakatsuka T, Asaoka Y, Ijichi H, Hirata Y, Otsuka M, Ikenoue T, Aburatani H, Omata M, Koike K. Histone demethylase KDM4C regulates sphere formation by mediating the cross talk between Wnt and Notch pathways in colonic cancer cells. Carcinogenesis. 2013 Oct;34(10):2380-8. doi: 10.1093/carcin/bgt174. Epub 2013 May 22.

Primary tumours modulate innate immune signalling to create pre-metastatic vascular hyperpermeability foci.

Hiratsuka S, Ishibashi S, Tomita T, Watanabe A, Akashi-Takamura S, Murakami M, Kijima H, Miyake K, Aburatani H, Maru Y. Primary tumours modulate innate immune signalling to create pre-metastatic vascular hyperpermeability foci. Nat Commun. 2013;4:1853. doi: 10.1038/ncomms2856.

Metabolic regulation of osteoclast differentiation and function.

Indo Y, Takeshita S, Ishii KA, Hoshii T, Aburatani H, Hirao A, Ikeda K. Metabolic regulation of osteoclast differentiation and function. J Bone Miner Res. 2013 Nov;28(11):2392-9. doi: 10.1002/jbmr.1976.

NF-E2 p45 is important for establishing normal function of platelets.

Fujita R, Takayama-Tsujimoto M, Satoh H, Gutierrez L, Aburatani H, Fujii S, Sarai A, Bresnick EH, Yamamoto M, Motohashi H. NF-E2 p45 is important for establishing normal function of platelets. Mol Cell Biol. 2013 Jul;33(14):2659-70. doi: 10.1128/MCB.01274-12. Epub 2013 May 6.

Androgen-responsive long noncoding RNA CTBP1-AS promotes prostate cancer.

Takayama K, Horie-Inoue K, Katayama S, Suzuki T, Tsutsumi S, Ikeda K, Urano T, Fujimura T, Takagi K, Takahashi S, Homma Y, Ouchi Y, Aburatani H, Hayashizaki Y, Inoue S. Androgen-responsive long noncoding RNA CTBP1-AS promotes prostate cancer. EMBO J. 2013 Jun 12;32(12):1665-80. doi: 10.1038/emboj.2013.99. Epub 2013 May 3.

Ly49Q, an ITIM-bearing NK receptor, positively regulates osteoclast differentiation.

Shoji K, Murayama T, Mimura I, Wada T, Kume H, Goto A, Ohse T, Tanaka T, Inagi R, van der Hoorn FA, Manabe I, Homma Y, Fukayama M, Sakurai T, Hasegawa T, Aburatani H, Kodama T, Nangaku M. Ly49Q, an ITIM-bearing NK receptor, positively regulates osteoclast differentiation. Am J Pathol. 2013 Jun;182(6):2191-203. doi: 10.1016/j.ajpath.2013.02.024. Epub 2013 Apr 17.

Sperm-associated antigen 4, a novel hypoxia-inducible factor 1 target, regulates cytokinesis, and its expression correlates with the prognosis of renal cell carcinoma.

Shoji K, Murayama T, Mimura I, Wada T, Kume H, Goto A, Ohse T, Tanaka T, Inagi R, van der Hoorn FA, Manabe I, Homma Y, Fukayama M, Sakurai T, Hasegawa T, Aburatani H, Kodama T, Nangaku M. Sperm-associated antigen 4, a novel hypoxia-inducible factor 1 target, regulates cytokinesis, and its expression correlates with the prognosis of renal cell carcinoma. Am J Pathol. 2013 Jun;182(6):2191-203. doi: 10.1016/j.ajpath.2013.02.024. Epub 2013 Apr 17.

Enrichment of stem-like cell population comprises transformation ability of Epstein-Barr virus latent membrane protein 2A for non-transformed cells.

Nakaya T, Kikuchi Y, Kunita A, Ishikawa S, Matsusaka K, Hino R, Aburatani H, Fukayama M. Enrichment of stem-like cell population comprises transformation ability of Epstein-Barr virus latent membrane protein 2A for non-transformed cells. Virus Res. 2013 Jun;174(1-2):108-15. doi: 10.1016/j.virusres.2013.03.009. Epub 2013 Mar 22.

Blimp1-mediated repression of negative regulators is required for osteoclast differentiation.

Osawa T, Tsuchida R, Muramatsu M, Shimamura T, Wang F, Suehiro J, Kanki Y, Wada Y, Yuasa Y, Aburatani H, Miyano S, Minami T, Kodama T, Shibuya M. Blimp1-mediated repression of negative regulators is required for osteoclast differentiation. Cancer Res. 2013 May 15;73(10):3019-28. doi: 10.1158/0008-5472.CAN-12-3231. Epub 2013 Mar 14.

Inhibition of histone demethylase JMJD1A improves anti-angiogenic therapy and reduces tumor-associated macrophages.

Osawa T, Tsuchida R, Muramatsu M, Shimamura T, Wang F, Suehiro J, Kanki Y, Wada Y, Yuasa Y, Aburatani H, Miyano S, Minami T, Kodama T, Shibuya M. Inhibition of histone demethylase JMJD1A improves anti-angiogenic therapy and reduces tumor-associated macrophages. Cancer Res. 2013 May 15;73(10):3019-28. doi: 10.1158/0008-5472.CAN-12-3231. Epub 2013 Mar 14.

Novel role of copper transport protein antioxidant-1 in neointimal formation after vascular injury.

Kohno T, Urao N, Ashino T, Sudhahar V, McKinney RD, Hamakubo T, Iwanari H, Ushio-Fukai M, Fukai T. Novel role of copper transport protein antioxidant-1 in neointimal formation after vascular injury. Arterioscler Thromb Vasc Biol. 2013 Apr;33(4):805-13. doi: 10.1161/ATVBAHA.112.300862. Epub 2013 Jan 24.