Modification of p115RhoGEF Ser330 regulates its RhoGEF activity.

Chow CR, Suzuki N, Kawamura T, Hamakubo T, Kozasa T. Modification of p115RhoGEF Ser330 regulates its RhoGEF activity. Cell Signal. 2013 Nov;25(11):2085-92. doi: 10.1016/j.cellsig.2013.06.012. Epub 2013 Jun 29. PMID: 23816534

Uhrf1-dependent ubiquitylation of histone H3 at lysine 23 couples maintenance DNA methylation and DNA replication.

Atsuya Nishiyama, Luna Yamaguchi1 Jafar Sharif, Yoshikazu Johmura, Takeshi Kawamura, Keiko Nakanishi, Shintaro Shimamura, Tatsuhiko Kodama, Fuyuki Ishikawa, Haruhiko Koseki and Makoto Nakanishi Uhrf1-dependent ubiquitylation of histone H3 at lysine 23 couples maintenance DNA methylation and DNA replication. Nature (2013) Oct 10;502(7470):249-253. doi: 10.1038/nature12488. Epub 2013 Sep 8. PMID: 24013172

BMP4/Thrombospondin-1 loop paracrinically inhibits tumor angiogenesis and suppresses the growth of solid tumors.

Tsuchida R, Osawa T, Wang F, Nishii R, Das B, Tsuchida S, Muramatsu M, Takahashi T, Inoue T, Wada Y, Minami T, Yuasa Y, Shibuya M. BMP4/Thrombospondin-1 loop paracrinically inhibits tumor angiogenesis and suppresses the growth of solid tumors. Oncogene. 2014 Jul 17;33(29):3803-11. doi: 10.1038/onc.2013.358. Epub 2013 Sep 9.

Endoplasmic reticulum protein quality control is determined by cooperative interactions between Hsp/c70 protein and the CHIP E3 ligase.

Matsumura Y, Sakai J, Skach WR. Endoplasmic reticulum protein quality control is determined by cooperative interactions between Hsp/c70 protein and the CHIP E3 ligase. J Biol Chem. 2013 Oct 25;288(43):31069-79. doi: 10.1074/jbc.M113.479345. Epub 2013 Aug 29.

Docking protein Gab1 is an essential component of postnatal angiogenesis after ischemia via HGF/c-met signaling.

Mimura I, Kanki Y, Kodama T, Nangaku M. Docking protein Gab1 is an essential component of postnatal angiogenesis after ischemia via HGF/c-met signaling. Kidney Int. 2014 Jan;85(1):31-8. doi: 10.1038/ki.2013.321. Epub 2013 Aug 28. Review.

Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms.

Kon A, Shih LY, Minamino M, Sanada M, Shiraishi Y, Nagata Y, Yoshida K, Okuno Y, Bando M, Nakato R, Ishikawa S, Sato-Otsubo A, Nagae G, Nishimoto A, Haferlach C, Nowak D, Sato Y, Alpermann T, Nagasaki M, Shimamura T, Tanaka H, Chiba K, et al. Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms. Nat Genet. 2013 Oct;45(10):1232-7. doi: 10.1038/ng.2731. Epub 2013 Aug 18.

The calcineurin-NFAT-angiopoietin-2 signaling axis in lung endothelium is critical for the establishment of lung metastases.

Minami T, Jiang S, Schadler K, Suehiro J, Osawa T, Oike Y, Miura M, Naito M, Kodama T, Ryeom S. The calcineurin-NFAT-angiopoietin-2 signaling axis in lung endothelium is critical for the establishment of lung metastases. Cell Rep. 2013 Aug 29;4(4):709-23. doi: 10.1016/j.celrep.2013.07.021. Epub 2013 Aug 15.

Maf promotes osteoblast differentiation in mice by mediating the age-related switch in mesenchymal cell differentiation.

Suzuki M, Kobayashi-Osaki M, Tsutsumi S, Pan X, Ohmori S, Takai J, Moriguchi T, Ohneda O, Ohneda K, Shimizu R, Kanki Y, Kodama T, Aburatani H, Yamamoto M. Maf promotes osteoblast differentiation in mice by mediating the age-related switch in mesenchymal cell differentiation. Genes Cells. 2013 Nov;18(11):921-33. doi: 10.1111/gtc.12086. Epub 2013 Aug 1.

A novel monoclonal antibody against the C-terminal region of aquaporin-4.

Ramadhanti J, Huang P, Kusano-Arai O, Iwanari H, Sakihama T, Misu T, Fujihara K, Hamakubo T, Yasui M, Abe Y. A novel monoclonal antibody against the C-terminal region of aquaporin-4. Monoclon Antib Immunodiagn Immunother. 2013 Aug;32(4):270-6. doi: 10.1089/mab.2013.0007.

GATA factor switching from GATA2 to GATA1 contributes to erythroid differentiation.

Suzuki M, Kobayashi-Osaki M, Tsutsumi S, Pan X, Ohmori S, Takai J, Moriguchi T, Ohneda O, Ohneda K, Shimizu R, Kanki Y, Kodama T, Aburatani H, Yamamoto M. GATA factor switching from GATA2 to GATA1 contributes to erythroid differentiation. Genes Cells. 2013 Nov;18(11):921-33. doi: 10.1111/gtc.12086. Epub 2013 Aug 1.

Osteoclast-secreted CTHRC1 in the coupling of bone resorption to formation.

Takeshita S, Fumoto T, Matsuoka K, Park KA, Aburatani H, Kato S, Ito M, Ikeda K. Osteoclast-secreted CTHRC1 in the coupling of bone resorption to formation. J Clin Invest. 2013 Sep;123(9):3914-24. doi: 10.1172/JCI69493. Epub 2013 Aug 1.

Targeting cancer cells resistant to hypoxia and nutrient starvation to improve anti-angiogeneic therapy.

Osawa T, Shibuya M. Targeting cancer cells resistant to hypoxia and nutrient starvation to improve anti-angiogeneic therapy. Cell Cycle. 2013 Aug 15;12(16):2519-20. doi: 10.4161/cc.25729. Epub 2013 Jul 29. No abstract available.

On the origin of proton mobility suppression in aqueous solutions of amphiphiles.

Xu J, Yamashita T, Agmon N, Voth GA. On the origin of proton mobility suppression in aqueous solutions of amphiphiles. J Phys Chem B. 2013 Dec 12;117(49):15426-35. doi: 10.1021/jp4051726. Epub 2013 Jul 22.

Modification of p115RhoGEF Ser(330) regulates its RhoGEF activity.

Chow CR, Suzuki N, Kawamura T, Hamakubo T, Kozasa T. Modification of p115RhoGEF Ser(330) regulates its RhoGEF activity. Cell Signal. 2013 Nov;25(11):2085-92. doi: 10.1016/j.cellsig.2013.06.012. Epub 2013 Jun 29.

High Performance Computing for Drug Development on K computer

H. Fujitani, K. Shinoda, T. Yamashita, T. Kodama High Performance Computing for Drug Development on K computer J Phys: Conf Ser. 2013, 454, p. 012018
https://doi.org/10.1088/1742-6596/454/1/012018

Integrated molecular analysis of clear-cell renal cell carcinoma.

Sato Y, Yoshizato T, Shiraishi Y, Maekawa S, Okuno Y, Kamura T, Shimamura T, Sato-Otsubo A, Nagae G, Suzuki H, Nagata Y, Yoshida K, Kon A, Suzuki Y, Chiba K, Tanaka H, Niida A, Fujimoto A, Tsunoda T, Morikawa T, Maeda D, Kume H, et al. Integrated molecular analysis of clear-cell renal cell carcinoma. Nat Genet. 2013 Aug;45(8):860-7. doi: 10.1038/ng.2699. Epub 2013 Jun 24.