Classification of Epstein-Barr virus-positive gastric cancers by definition of DNA methylation epigenotypes.

Matsusaka K, Kaneda A, Nagae G, Ushiku T, Kikuchi Y, Hino R, Uozaki H, Seto Y, Takada K, Aburatani H, Fukayama M. Classification of Epstein-Barr virus-positive gastric cancers by definition of DNA methylation epigenotypes. Cancer Res. 2011 Dec 1;71(23):7187-97. doi: 10.1158/0008-5472.CAN-11-1349. Epub 2011 Oct 11.

The application of an alanine-substituted mutant of the C-terminal fragment of Clostridium perfringens enterotoxin as a mucosal vaccine in mice.

Suzuki H, Kondoh M, Kakutani H, Yamane S, Uchida H, Hamakubo T, Yagi K. The application of an alanine-substituted mutant of the C-terminal fragment of Clostridium perfringens enterotoxin as a mucosal vaccine in mice. Biomaterials. 2012 Jan;33(1):317-24. doi: 10.1016/j.biomaterials.2011.09.048. Epub 2011 Oct 7.

TLS and PRMT1 synergistically coactivate transcription at the survivin promoter through TLS arginine methylation.

Kun Du, Shigeki Arai, Takeshi Kawamura, Akio Matsushita, Riki Kurokawa. TLS and PRMT1 synergistically coactivate transcription at the survivin promoter through TLS arginine methylation. Biochem Biophys Res Commun. 2011 Jan 28;404(4):991-6. Epub 2010 Dec 25.

Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. An FFPE proteomic study.

Nomura M, Fukuda T, Fujii K, Kawamura T, Tojo H, Kihara M, Bando Y, Gazdar AF, Tsuboi M, Oshiro H, Nagao T, Ohira T, Ikeda N, Gotoh N, Kato H, Marko-Varga G, Nishimura T. Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. An FFPE proteomic study. J Clin Bioinforma. 2011 Sep 3;1(1):23.PMID: 21888658

Alzheimer’s disease: cholesterol, membrane rafts, isoprenoids and statins.

Nakashima T, Hayashi M, Fukunaga T, Kurata K, Oh-Hora M, Feng JQ, Bonewald LF, Kodama T, Wutz A, Wagner EF, Penninger JM, Takayanagi H. Alzheimer’s disease: cholesterol, membrane rafts, isoprenoids and statins. Nat Med. 2011 Sep 11;17(10):1231-4. doi: 10.1038/nm.2452.

Downregulation of receptor for activated C-kinase 1 (RACK1) suppresses tumor growth by inhibiting tumor cell proliferation and tumor-associated angiogenesis.

Wang F, Osawa T, Tsuchida R, Yuasa Y, Shibuya M. Downregulation of receptor for activated C-kinase 1 (RACK1) suppresses tumor growth by inhibiting tumor cell proliferation and tumor-associated angiogenesis. Cancer Sci. 2011 Nov;102(11):2007-13. doi: 10.1111/j.1349-7006.2011.02065.x. Epub 2011 Sep 22.

Mechanism of cell death resulting from DNA interstrand cross-linking in mammalian cells.

Osawa T, Davies D, Hartley JA. Mechanism of cell death resulting from DNA interstrand cross-linking in mammalian cells. Cell Death Dis. 2011 Aug 4;2:e187. doi: 10.1038/cddis.2011.70.

DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response.

Yoshimatsu Y, Yamazaki T, Mihira H, Itoh T, Suehiro J, Yuki K, Harada K, Morikawa M, Iwata C, Minami T, Morishita Y, Kodama T, Miyazono K, Watabe T. DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. J Cell Sci. 2011 Aug 15;124(Pt 16):2753-62. doi: 10.1242/jcs.083998.

Proteomic analysis of native hepatocyte nuclear factor-4α (HNF4α) isoforms, phosphorylation status, and interactive cofactors.

Daigo K, Kawamura T, Ohta Y, Ohashi R, Katayose S, Tanaka T, Aburatani H, Naito M, Kodama T, Ihara S, Hamakubo T. Proteomic analysis of native hepatocyte nuclear factor-4α (HNF4α) isoforms, phosphorylation status, and interactive cofactors. J Biol Chem. 2011 Jan 7;286(1):674-86. doi: 10.1074/jbc.M110.154732. Epub 2010 Nov 3. Erratum in: J Biol Chem. 2013 Aug 16;288(33):24161.

Fenofibrate suppresses growth of the human hepatocellular carcinoma cell via PPARα-independent mechanisms.

Yamasaki D, Kawabe N, Nakamura H, Tachibana K, Ishimoto K, Tanaka T, Aburatani H, Sakai J, Hamakubo T, Kodama T, Doi T. Fenofibrate suppresses growth of the human hepatocellular carcinoma cell via PPARα-independent mechanisms. Eur J Cell Biol. 2011 Aug;90(8):657-64. doi: 10.1016/j.ejcb.2011.02.005. Epub 2011 Apr 21.

ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif.

Morikawa M, Koinuma D, Tsutsumi S, Vasilaki E, Kanki Y, Heldin CH, Aburatani H, Miyazono K. ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif. Nucleic Acids Res. 2011 Nov 1;39(20):8712-27. doi: 10.1093/nar/gkr572. Epub 2011 Jul 15.

Homozygously deleted gene DACH1 regulates tumor-initiating activity of glioma cells.

Watanabe A, Ogiwara H, Ehata S, Mukasa A, Ishikawa S, Maeda D, Ueki K, Ino Y, Todo T, Yamada Y, Fukayama M, Saito N, Miyazono K, Aburatani H. Homozygously deleted gene DACH1 regulates tumor-initiating activity of glioma cells. Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12384-9. doi: 10.1073/pnas.0906930108. Epub 2011 Jul 12.

ASCL1-coexpression profiling but not single gene expression profiling defines lung adenocarcinomas of neuroendocrine nature with poor prognosis.

Fujiwara T, Hiramatsu M, Isagawa T, Ninomiya H, Inamura K, Ishikawa S, Ushijima M, Matsuura M, Jones MH, Shimane M, Nomura H, Ishikawa Y, Aburatani H. ASCL1-coexpression profiling but not single gene expression profiling defines lung adenocarcinomas of neuroendocrine nature with poor prognosis. Lung Cancer. 2012 Jan;75(1):119-25. doi: 10.1016/j.lungcan.2011.05.028. Epub 2011 Jul 6.

Epigenetic regulation of osteoclast differentiation: possible involvement of Jmjd3 in the histone demethylation of Nfatc1.

Yasui T, Hirose J, Tsutsumi S, Nakamura K, Aburatani H, Tanaka S. Epigenetic regulation of osteoclast differentiation: possible involvement of Jmjd3 in the histone demethylation of Nfatc1. J Bone Miner Res. 2011 Nov;26(11):2665-71. doi: 10.1002/jbmr.464.

Gene expression profiling of mouse growth plate cartilage by laser microdissection and microarray analysis.

Isshiki H, Sato K, Horiuchi K, Tsutsumi S, Kano M, Ikegami H, Abe H, Umezawa A, Aburatani H, Toyama Y. Gene expression profiling of mouse growth plate cartilage by laser microdissection and microarray analysis. J Orthop Sci. 2011 Sep;16(5):670-2. doi: 10.1007/s00776-011-0119-2. Epub 2011 Jul 1. No abstract available.

Pathological role of osteoclast costimulation in arthritis-induced bone loss.

Idrus E, Nakashima T, Wang L, Hayashi M, Okamoto K, Kodama T, Tanaka N, Taniguchi T, Takayanagi H. Pathological role of osteoclast costimulation in arthritis-induced bone loss. Biochem Biophys Res Commun. 2011 Jul 8;410(3):620-5. doi: 10.1016/j.bbrc.2011.06.040. Epub 2011 Jun 13.